Temazepam

CAS 846-50-4 MFCD00057904

化学结构图

846-50-4
SMILES: CN1C(=O)C(O)N=C(c2ccccc2)c2cc(Cl)ccc21

化学属性

Mol. FormulaC16 H13 Cl N2 O2
Mol. Weight300.74
Flash Point11 °C
Melting Point119-121°C

别名和识别编码

Chemical NameTemazepam
CAS Number846-50-4
Synonym 1,3-Dihydro-7-chloro-3-hydroxy-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one 2H-1,4-Benzodiazepin-2-one, 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-3-hydroxy-1-methyl-5-phenyl- 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl- 3 Hydroxydiazepam 3-Hydroxydiazepam 7-Chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl- 7-Chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one 7-Chloro-3-hydroxy-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one 7-chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-2h-4-benzodiazepin-2-one AURORA KA-7273 Apo Temazepam Apo-Temazepam Cerepax Crisonar Dasuen Diazepam, 3-hydroxy ER 115 Euhypnos Euipnos Gelthix {LY}
MDL NumberMFCD00057904
PubChem Substance ID5391
EC Number212-688-1
Chemical Name Translation
Wiswesser Line NotationT67 GNV JN IHJ CG G1 IQ KR
Beilstein Registry Number0759300
InChIInChI=1S/C16H13ClN2O2/c1-19-13-8-7-11(17)9-12(13)14(18-15(20)16(19)21)10-5-3-2-4-6-10/h2-9,15,20H,1H3
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分类

  • Alphabetic, Analytical Standards, Analytical/Chromatography, Benzodiazepin Analoga Structure, Chemical Structure, Chromatography, Drugs & Metabolites, Drugs of Abuse, Forensic and Veterinary Standards, Neat Compounds, T, TA - TE
  • {SNA} Alphabetic, Analytical Standards, Analytical/Chromatography, Benzodiazepin Analoga Structure, Chemical Structure, Chromatography, Drugs & Metabolites, Drugs of Abuse, Forensic and Veterinary Standards, Neat Compounds, T, TA - TE

产品应用

  • Pharmacologically active metabolite of Diazepam.

相关文献及参考

  • Sarteschi, P., et al.: Arzneim.-Forsch., 22, 93 (1972),
  • Schwandt, H.J., et al.: Xenobiotica, 4, 733 (1974),
  • Curry, S.H., et al.: Br. J. Pharmacol., 57, 427 (1976),
  • Merck 14 ,9133

安全信息

RTECSDF1225000
GHS Symbol
WGK Germany3
Signal word Warning
Hazard statements
  • H302 Harmful if swallowed 吞食有害
Hazard Codes Xn Xn,T,F
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Storage condition -20°C 2-8°C
UN Number UN 1230 3/PG 2
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
Risk Statements
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
  • R11 Highly flammable 非常易燃
  • R22 Harmful if swallowed 吞咽有害
  • R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性：吸入，皮肤接触和吞食都会产生十分严重的不可逆危险
Restrict {} 精神药品 精麻类化学品 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 429 ug/kg
TOXIC EFFECTS :
   Behavioral - excitement
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   JCLPDE Journal of Clinical Psychiatry.  (Physicians Postgraduate Press,
   Inc., POB 240008, Memphis, TN 38124)  V.39-    1978-
   Volume(issue)/page/year: 46,280,1985

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 600 ug/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   HUPSEC Human Psychopharmacology.  (John Wiley & Sons Ltd., Baffins Lane,
   Chichester, W.Sussex PO19 1UD, United Kingdom)  V.1-    1986-
   Volume(issue)/page/year: 10,449,1995

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATIO

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 600 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRUGAY Drugs. International Journal of Current Therapeutics and Applied
   Pharmacology Reviews.  (ADIS Press International Inc., Suite B-30, Oxford
   Ct. Business Center, 582 Middletown Blvd., Langho

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 370 mg/kg
TOXIC EFFECTS :
   Behavioral - anticonvulsant
REFERENCE :
   EJPHAZ European Journal of Pharmacology.  (Elsevier Science Pub. B.V., POB
   211, 1000 AE Amsterdam, Netherlands)  V.1-    1967- Volume(issue)/page/year:
   4,467,1968

Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P301+P312
  • P301+P317
  • P330 Rinse mouth. 漱口
  • P501 Dispose of contents/container to..… 处理内容物/容器.....

其他信息

  • 储运特性:库房通风低温干燥; 与食品原料分开储运
  • 类别:有毒物质
  • 毒性分级:高毒
  • MOL 文件:846-50-4.mol
  • 可燃性危险特性:可燃; 火场释放有毒氮氧化物, 氯化物烟雾
  • 急性毒性:口服- 大鼠 LD50: 2000 毫克/ 公斤; 口服- 小鼠 LD50:370 毫克/ 公斤
  • 灭火剂:水, 二氧化碳, 泡沫, 砂土
  • Sigma Aldrich:846-50-4(sigmaaldrich)

系列性分类

  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Forensic and Veterinary Standards - Chromatography
  5. Drugs of Abuse - Forensic and Veterinary Standards
  6. Chemical Structure - Drugs of Abuse
  7. Benzodiazepin Analoga Structure - Chemical Structure

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