GUANOSINE 5'-O-(2-THIODIPHOSPHATE) TRILITHIUM SALT
CAS 97952-36-8 MFCD00057735
化学结构图
SMILES: [Li+].[Li+].[Li+].NC1NC(=O)C2N=CN([C@@H]3O[C@H](COP([O-])(=O)OP([O-])([O-])=S)[C@@H](O)[C@H]3O)C=2N=1
化学属性
| Mol. Formula | C10H12Li3N5O10P2S |
|---|---|
| Mol. Weight | 477.07 |
别名和识别编码
| Chemical Name | Guanosine 5'-[β-thio]diphosphate trilithium salt |
|---|---|
| Synonym | GDPβS trilithium salt GDPβS trilithium salt GDP-β-S-Li3 GDP-β-S GDP-β-S GDP-β-S-Li3 GDPβS trilithium salt GDP-β-S-Li3 GDP-β-S |
| MDL Number | MFCD00057735 |
| Beilstein Registry Number | 8181243 |
| CAS Number | 97952-36-8 |
| EC Number | 308-328-9 |
| PubChem Substance ID | 329799966 |
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分类
- Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, G, G Protein Function, G Proteins and Cyclic Nucleotides, Reagents
- {SNA} Bioactive Small Molecule Alphabetical Index, G, G Protein Function, G Proteins and Cyclic Nucleotides, Reagents, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- {SNA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, G, G Protein Function, G Proteins and Cyclic Nucleotides, Reagents
相关文献及参考
- Kucera, G.L., et al., Inhibition of GDP-β-S of agonist-activated phospholipase C in human platelets requires cell permeabilization. Biochem. Biophys. Res. Commun. 153 , 417-421, (1988) 摘要
- Oberdisse , E., et al., GDP-β-S enhances the activation of phospholipase C caused by thrombin in human platelets: Evidence for an inhibitory GTP-binding protein. Biochem. Biophys. Res. Commun. 144 , 1188-1196, (1987) 摘要
- Ho, R.J., et al., Conditional inhibition of forskolin-activated adenylate cyclase by guanosine diphosphate and its analog. Arch. Biochem. Biophys. 251 , 148-155, (1986) 摘要
- Moon, E.Y., et al., Gi-protein Inhibitor, Guanosine 5'-O-(2-thiodiphosphate), Induces Senescence-associated Beta-galactosidase Positive Cell Formation Through CREB Phosphorylation. Leuk. Res. 86 , 683-90, (2010)
- Tam, A.K., et al., Role For Protein Kinase C In Controlling Aplysia Bag Cell Neuron Excitability. Neuroscience 179 , 41-55, (2011) 摘要
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
