CAS 148-82-3 MFCD00057717-Melphalan 美法仑 TAO{mole}

Melphalan 美法仑

CAS 148-82-3 MFCD00057717

化学结构图

SMILES: NC(Cc1ccc(N(CCCl)CCCl)cc1)C(=O)O

化学属性

Mol. Formula	C13H18Cl2N2O2
Mol. Weight	305
Melting Point	180
Solubility	95% ethanol and 1 drop 6 N HCl: 0.05 g/mL, clear
Appearance	powder

别名和识别编码

Chemical Name	Melphalan
Synonym	3(p-(bis(2-chloroethyl)amino)phenyl)-l-alanine 3-(p-(Bis(2-chloroethyl)amino)phenyl)-L-alanine 3-p-(Di(2-chloroethyl)amino)-phenyl-L-alanine 3025c.b. 3025cb 4-[Bis(2-chloroethyl)amino]-L-phenylalanine Alanine nitrogen mustard L-3{对[双(2-氯乙基)胺基]苯基}丙氨酸 L-Sarcolysin NCI-C04853 NSC-8806 Phenylalanine nitrogen mustard alaninenitrogenmustard at-290 cb3025 l-3-(p-(bis(2-chloroethyl)amino)phenyl)alanine l-sarcolysin l-sarkolysin levofalan p-Bis(beta-chloroethyl)aminophenylalanine 左旋溶肉瘤素左旋苯丙氨酸氮芥爱克兰癌克安美尔法仑美法仑
MDL Number	MFCD00057717
PubChem Substance ID	460612
Beilstein Registry Number	2816456
EC Number	205-726-3
CAS Number	148-82-3
Chemical Name Translation	美法仑
Merck Number	13,5850
Wiswesser Line Notation	QVYZ1R DN2G2G -L
LabNetwork Molecule ID	LN00197680
InChI	InChI=1S/C13H18Cl2N2O2/c14-5-7-17(8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19/h1-4,12H,5-9,16H2,(H,18,19)/t12-/m0/s1

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安全信息

RTECSAY3675000

GHS Symbol

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P284 Wear respiratory protection.? 佩戴呼吸保护装置。
P302+P350
P302+P352
P304+P340
P305+P351+P338
P307+P311
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用

Hazard statements

H350 May cause cancer 可能致癌
H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
H330 Fatal if inhaled 吸入致命
H310 Fatal in contact with skin 皮肤接触致命
H300 Fatal if swallowed 吞食致命

WGK Germany3

Signal word Danger

Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Hazard Codes 6.1 T+

Safety Statements

S22 Do not breathe dust 不要吸入粉尘；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；

Risk Statements

R26/27/28 Very toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有剧毒
R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
R45 May cause cancer 可能致癌
R46 May cause inheritable genetic damage 可能引起遗传基因损害
R62 Possible risk of impaired fertility 有削弱生殖能力的危险
R63 Possible risk of harm to the unborn child 可能危害未出生婴儿

Packing GroupII

Hazard Class6.1(a)

UN Number 2811 UN 2811 6.1/PG 2

Restrict {} 剧毒化学品危险品

Warnings 危化品目录(2015)

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 66 mg/kg/4Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Blood - leukemia
REFERENCE :
   BLOOAW Blood.  (Grune & Stratton, Inc., 465 S. Lincoln Dr., Troy, MO 63379)
   V.1-    1946-  Volume(issue)/page/year: 44,333,1974

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 60 mg/kg/26W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Blood - lymphoma, including Hodgkin's disease
REFERENCE :
   RRCRBU Recent Results in Cancer Research.  (Springer-Verlag New York, Inc.,
   Service Center, 44 Hartz Way, Secaucus, NJ 07094)  V.1-    1965-
   Volume(issue)/page/year: 52,1,1975

TYPE OF TEST            : T

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 23 mg/kg/2Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Blood - leukemia
REFERENCE :
   AMSVAZ Acta Medica Scandinavica.  (Almqvist & Wiksell, POB 45150, S-10430
   Stockholm, Sweden) V.52-224, 1919-88.  Volume(issue)/page/year: 211,203,1982

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 17 mg/kg/4Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Blood - leukemia
REFERENCE :
   AMSVAZ Acta Medica Scandinavica.  (Almqvist & Wiksell, POB 45150, S-10430
   Stockholm, Sweden) V.52-224, 1919-88.  Volume(issue)/page/year: 211,203,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
R

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 4500 mg/kg
TOXIC EFFECTS :
   Behavioral - anorexia (human)
   Gastrointestinal - hypermotility, diarrhea
   Blood - agranulocytosis
REFERENCE :
   NZMJAX New Zealand Medical Journal.  (New Zealand Medical Assoc., P.O. Box
   156, Wellington, New Zealand)  V.1-    1900-  Volume(issue)/page/year:
   97,816,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - infant
DOSE/DURATION           : 28 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Blood - agranulocytosis
   Blood - thrombocytopenia
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 2,1048,1984

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 11200 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shib

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 8140 mg/kg
TOXIC EFFECTS :
   Behavioral - anorexia (human)
   Gastrointestinal - hypermotility, diarrhea
   Blood - agranulocytosis
REFERENCE :
   NZMJAX New Zealand Medical Journal.  (New Zealand Medical Assoc., P.O. Box
   156, Wellington, New Zealand)  V.1-    1900-  Volume(issue)/page/year:
   97,816,1984

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURAT

TYPE OF TEST            : DNA damage
TEST SYSTEM

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 200 ug/plate
REFERENCE :
   PNASA6 Proceedings

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   ANTRD4 Anticancer Researc

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Unreported
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 10 mmol/L
REFERENCE :
   ANYAA9 Annals of the New York Academy of Sciences.  (New York Academy of
   Sciences, 2 E. 63rd St., New York, NY 10021)  V.1-    1877-
   Volume(issue)/page/year: 160,228,1969

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 100 ug/disc
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   34,1658,1974

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Human Leukocyte
DOSE/DURATION           : 10 umol/L
REFERENCE :
   EJCODS European Journal of Cancer and Clinical Oncology.  (Pergamon Press,
   c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591)  V.17(7)-
   25, 1981-89.  For publisher information, see EJCAEL Volume(issue)/page/year:
   17,991,1981

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 1 mg/L/1H (Continuous)
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   40,1169,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 3750 ug/kg
SEX/DURATION            : female 25 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 1,1174,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - woman
DOSE                    : 5946 ug/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 1,1425,1987

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - child
DOSE                    : 8800 ug/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - ovaries, fallopian tubes
   Reproductive - Maternal Effects - other effects
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 1,1425,1987

其他信息

MSDS 信息:L-Phenylalanine mustard(148-82-3).msds
F:8
用途一:为烷化剂类抗肿瘤药，用于多发性骨髓瘤、乳腺癌、卵巢癌、慢性淋巴细胞和粒细胞型白血病、恶性淋巴瘤、多发性骨髓瘤有效。对动脉灌注治疗肢体恶性肿瘤如恶性黑色素瘤、软组织肉瘤和骨肉瘤有较好的疗效。消旋体对睾丸精原细胞瘤疗效较好。制剂有片剂、注射剂。
color:white
MOL 文件:148-82-3.mol
Sigma Aldrich:148-82-3(sigmaaldrich)