5-((1H-Indol-3-Yl)Methyl)-3-Methyl-2-Thioxoimidazolidin-4-One 5-(1H-吲哚-3-基甲基)-3-甲基-2-硫酮-4-咪唑烷酮

CAS 4311-88-0 MFCD00056916

化学结构图

4311-88-0
SMILES: CN1C(=O)C(Cc2c[nH]c3ccccc23)NC1=S

化学属性

Mol. FormulaC13H13N3OS
Mol. Weight259
TSCANo
SolubilityDMSO 52 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

别名和识别编码

Chemical Name5-((1H-Indol-3-Yl)Methyl)-3-Methyl-2-Thioxoimidazolidin-4-One
CAS Number4311-88-0
MDL NumberMFCD00056916
Synonym 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-Imidazolidinone MTH-DL-Tryptophan N-[(4-acetamidophenyl)carbamothioyl]-4-tert-butylbenzamide
PubChem Substance ID24724559
Chemical Name Translation5-(1H-吲哚-3-基甲基)-3-甲基-2-硫酮-4-咪唑烷酮
LabNetwork Molecule IDLN00332807
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分类

  • {SNA} Apoptosis Inhibitors, Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, N, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Apoptosis Inhibitors, Apoptosis and Cell Cycle, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, N
  • {SNA} Apoptosis Inhibitors, Apoptosis and Cell Cycle, Bioactive Small Molecules, Cell Signaling and Neuroscience, N, 细胞生物学

相关文献及参考

  • [2]. Linkermann A, et al. The RIP1-kinase inhibitor necrostatin-1 prevents osmotic nephrosis and contrast-induced AKI in mice. J Am Soc Nephrol. 2013 Oct;24(10):1545-57.
  • [3]. Huang C, et al. Shikonin kills glioma cells through necroptosis mediated by RIP-1. PLoS One. 2013 Jun 28;8(6):e66326.
  • [4]. Feyen D, et al. Increasing short-term cardiomyocyte progenitor cell (CMPC) survival by necrostatin-1 did not further preserve cardiac function. Cardiovasc Res. 2013 Jul 1;99(1):83-91.
  • [5]. Zhou K, et al. RIP1-RIP3-DRP1 pathway regulates NLRP3 inflammasome activation following subarachnoid hemorrhage. Exp Neurol. 2017 Sep;295:116-124.
  • [1]. Degterev A, et al. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol. 2005 Jul;1(2)
  • [1]. Degterev A, et al. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol. 2005 Jul;1(2):112-9.

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage condition Light Sensitive 储存温度-20°C
GHS Symbol
Signal word Warning
Safety Statements
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
Risk Statements
  • R36/37/39
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。

其他信息

  • Necrostatin-1

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Apoptosis and Cell Cycle - Cell Signaling and Neuroscience
  5. Apoptosis Inhibitors - Apoptosis and Cell Cycle
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Apoptosis and Cell Cycle - Cell Signaling and Neuroscience
  5. Apoptosis Inhibitors - Apoptosis and Cell Cycle
  1. Medical Research Areas
  2. Metabolism
  3. Indoleamine 2,3-Dioxygenase (IDO)  (吲哚胺 2,3 双加氧酶)

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