CAS 17230-88-5 MFCD00056838-Danazol 达那唑 TAO{mole}

Danazol 达那唑

CAS 17230-88-5 MFCD00056838

化学结构图

SMILES: C[C@]12CC[C@H]3[C@@H](CCC4=CC5ON=CC=5C[C@@]43C)[C@@H]1CC[C@@]2(O)C#C

化学属性

Mol. Formula	C22H27NO2
Mol. Weight	337.50

别名和识别编码

Chemical Name	Danazol
CAS Number	17230-88-5
Synonym	17-alpha-2,4-Pregnadien-20-yno(2,3-d)isoxazol-17-ol (17?)-Pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol Danol Bonzol Cyclomen 17-alpha-Pregn-4-en-20-yno(2,3-d)isoxazol-17-ol Danazol Pregna-2,4-dien-20-yno(2,3-d)isoxazol-17-ol, (17-alpha)- 17β-Hydroxy-2,4,17α-pregnadien-20-yno[2,3-d]isoxazole Win-17757 Danatrol Danocrine 2,4,17α-Pregnadien-20-yno[2,3-d]isoxazol-17-ol 17alpha-Pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol; 17beta-Hydroxy-2,4,17alpha-pregnadien-20-yno[2,3-d]isoxazole; 2,4,17alpha-Pregnadien-20-yno[2,3-d]-isoxa-zol-17-ol WIN 17757 17?-Ethynyl-17?? hydroxy-4-androsteno[2,3-d]isoxazole
MDL Number	MFCD00056838
PubChem Substance ID	24277708
EC Number	241-270-1
Wiswesser Line Notation	T G5 E6 B665 HON EU&TTTTJ M1 Q1 RQ R1UU1
Chemical Name Translation	达那唑

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产品应用

Anterior pituitary supressant. Anabolic steroid derivative of ethisterone, with mild androgenic side effects (an impeded androgen). Antigonadotropin.

安全信息

WGK Germany3

GHS Symbol

Precautionary statements

P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。

Signal word Warning

Hazard statements

H332 Harmful if inhaled 吸入有害
H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
H312 Harmful in contact with skin 皮肤接触有害

Hazard Codes Xn

RTECSTU4157070

Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

Safety Statements

S22 Do not breathe dust 不要吸入粉尘；
S36 Wear suitable protective clothing 穿戴适当的防护服；

Risk Statements

R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 2920 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   JSONAU Journal of Surgical Oncology.  (Alan R. Liss, Inc., 41 E. 11th St.,
   New York, NY 10003) V.1-    1969-  Volume(issue)/page/year: 28,114,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YAKUD5 Gekkan Yakuji.  Pharmaceuticals Monthly.  (Yakugyo Jihosha, Inaoka
   Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan)  V.1-   1959-
   Volume(issue)/page/year: 25,691,1983

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4830 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China
   International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24-
   1989-  Volume(issue)/page/year: 25,55,1990

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 120 mg/kg/10D-I
TOXIC EFFECTS :
   Skin and Appendages - dermatitis, allergic (after systemic exposure)
REFERENCE :
   AIMDAP Archives of Internal Medicine.  (AMA, 535 N. Dearborn St., Chicago,
   IL 60610)  V.1-    1908-  Volume(issue)/page/year: 145,2251,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATI

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YAKUD5 Gekkan Yakuji.  Pharmaceuticals Monthly.  (Yakugyo Jihosha, Inaoka
   Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, T

TYPE OF TEST            : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE       : Intratesticular
TEST SYSTEM             : Mammal - dog
DOSE/DURATION           : 13 mg/kg
REFERENCE :
   FOBGA8 Folia Biologica (Krakow).  (Ars Polona, POB 1001, 00-068 Warsaw 1,
   Poland)  V.1-    1953-  Volume(issue)/page/year: 23.305,1975

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - gerbil
DOSE                    : 880 mg/kg
SEX/DURATION            : male 22 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   accessory glands
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1960-
   Volume(issue)/page/year: 61,217,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 120 mg/kg
SEX/DURATION            : female 30 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
REFERENCE :
   INJFA3 International Journal of Fertility.  (Allen Press, 1041 New
   Hampshire,  St., Lawrence, KS 66044)  V.1-    1955- Volume(issue)/page/year:
   25,75,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 5600 mg/kg
SEX/DURATION            : female 14 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - ovaries, fallopian tubes
REFERENCE :
   JIMRBV Journal of International Medical Research.  (Cambridge Medical Pub.
   Ltd., 435/437 Wellingborough Rd., Northampton, NN1 4EZ, UK)  V.1-    1972-
   Volume(issue)/page/year: 5(Suppl 3),1,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 880 mg/kg
SEX/DURATION            : male 22 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duc