(6aS,7S,8aS,8bS,11aS,12aS,12bS)-6b-Fluoro-7-hydroxy-8b-(2-hydroxyacetyl)-6a,8a,10,10-tetramethyl-6a,6b,7,8,8a,8b,11a,12,12a,12b-decahydro-1H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4(2H)-one (6aS,7S,8aS,8bS,11aS,12aS,12bS)-6b-氟-7-羟基-8b-(2-羟基乙酰基)-6a,8a,10,10-四甲基-6a,6b,7,8,8a,8b,11a,12,12a,12b-十氢-1H-萘[2',1':4,5]茚满[1,2-d][1,3]二氧四环-4(2H)-酮
CAS 76-25-5 MFCD00056834
化学结构图
SMILES: CC1(C)O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1
化学属性
| Mol. Formula | C24H31FO6 |
|---|---|
| Mol. Weight | 434.50 |
| Melting Point | 294°C |
| TSCA | Yes |
| Density | 1.33 |
别名和识别编码
| Chemical Name | (6aS,7S,8aS,8bS,11aS,12aS,12bS)-6b-Fluoro-7-hydroxy-8b-(2-hydroxyacetyl)-6a,8a,10,10-tetramethyl-6a,6b,7,8,8a,8b,11a,12,12a,12b-decahydro-1H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4(2H)-one |
|---|---|
| CAS Number | 76-25-5 |
| Synonym | Delphicort Extracort 9-alpha-Fluoro-16-alpha-17-alpha-isopropyledenedioxyprednisolone 9-alpha-Fluoro-16-alpha-hydroxyprednisolone 16-alpha,17-alpha-acetonide Aristoderm Flutone 9a-Fluoro-11b,16a,17a,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide; 9a-Fluoro-16a-hydroxyprednisolone 16a,17a-acetonide Aristogel (11?,16?)-9-Fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-pregna-1,4-diene-3,20-dione Veta Adcortyl Acetospan 9-Fluoro-11,21-dihydroxy-16,17-isopropylidenedioxy-1,4-pregnadiene-3,20-dione Tricinolon Azmacort 9α-氟-11β,16α,17α,21-四羟基-1,4-孕甾二烯-3,20-二酮-16,17-丙酮化合物 9α-氟-16α-羟基波尼松龙 16α,17α-丙酮化合物 Ftorocort 醋酸曲安缩松 9-alpha-Fluoro-16-hydroxyprednisolone acetonide 9α-氟-11β,16α,17α,21-四羟基-1,4-孕甾二烯-3,20-二酮-16,17-丙酮化合物 9α-氟-16α-羟基波尼松龙 16α,17α-丙酮化合物 Aristocort acetonide 9alpha-Fluoro-16alpha-hydroxyprednisolone-16alpha,17alpha-acetonide Triam Vetalog Triamsinolone acetonide 9-alpha-Fluoro-11-beta,21-dihydroxy-16-alpha-isopropylidenedioxy-1,4-pregnadiene,3,20-dione Triamcinolone acetonide Kenalog 曲安奈德 9-alpha-Fluoro-16-alpha-17-alpha-isopropylidenedioxy-delta-1-hydrocortisone Kenacort-A |
| MDL Number | MFCD00056834 |
| PubChem Substance ID | 6436 |
| EC Number | 200-948-7 |
| Merck Number | 9596 |
| Reaxys-RN | 60069 |
| Beilstein Registry Number | 19(5)6,568 |
| Chemical Name Translation | (6aS,7S,8aS,8bS,11aS,12aS,12bS)-6b-氟-7-羟基-8b-(2-羟基乙酰基)-6a,8a,10,10-四甲基-6a,6b,7,8,8a,8b,11a,12,12a,12b-十氢-1H-萘[2',1':4,5]茚满[1,2-d][1,3]二氧四环-4(2H)-酮 |
| Wiswesser Line Notation | T F5 E5 B666 GO IO RV AHTTTT&J A1 BF CQ E1 FV1Q H1 H1 |
| LabNetwork Molecule ID | LN01313477 |
| InChI | InChI=1S/C24H31FO6/c1-20(2)30-19-10-16-15-6-5-13-9-14(27)7-8-21(13,3)23(15,25)17(28)11-22(16,4)24(19,31-20)18(29)12-26/h7-9,15-17,19,26,28H,5-6,10-12H2,1-4H3/t15-,16-,17-,19+,21-,22-,23-,24+/m0/s1 |
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资金保障
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现货库存
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分类
- {SA} All Doping Standards (A-Z), Alphabetic,
- {SNA} Additional Standards, All Doping Standards (A-Z), Analytical Standards, Chemical Structure, Chromatography, Corticosteroids, Drugs & Metabolites, Drugs of Abuse, Forensic and Veterinary Standards, Horse Doping Drugs, Neat Compounds, Pharmaceuticals, Illicit Drugs & Alcohol, Steroid, Steroids / Doping Agents Standards, 分析/色谱
- {SNA} Alphabetical Index of Analytical Standards, All Doping Standards (A-Z), Analytical Standards, Analytical/Chromatography, Chemical Structure, Chromatography, Corticosteroids, Doping Substances,
- {SNA} Analytical Standards,
产品应用
- A glucocorticoid, antiasthmatic (inhalant); antiallergic (nasal).
相关文献及参考
- [2]. Zhen Xiang, et al. Glucocorticoids improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels. Int J Biol Sci 2020; 16(13):2382-2391.
- Bernstein, I.L., et al.: Chest, 81, 20 (1982),
- Florey, K., et al.: Anal. Profiles Drug Subs., 1, 397 (1972),
- Merck: 14,9596 Beilstein:19(5)6,568
- [1]. http://en.wikipedia.org/wiki/Triamcinolone_acetonide
- [1]. http://en.wikipedia.org/wiki/Triamcinolone_acetonide
- [2]. Zhen Xiang, et al. Glucocorticoids improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels. Int J Biol Sci 2020; 16(13):2382-2391.
安全信息
GHS Symbol
- P308+P313
- P201 Obtain special instructions before use. 使用前获取专门指示。
- H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
- H303 May be harmfully swallowed 吞食可能有害
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
- R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
- R22 Harmful if swallowed 吞咽有害
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 13100 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 6,44,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 21,2117,1979
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Human - man DOSE/DURATION : 571 ug/kg TOXIC EFFECTS : Vascular - shock Skin and Appendages - dermatitis, other (after systemic exposure) Immunological Including Allergic - anaphylaxis REFERENCE : APHRER Annals of Pharmacotherpy. (Harvey Whitney Books Co., POB 42696, Cincinnati, OH 45242) V. 26- 1992- Volume(issue)/page/year: 28,1310,1994
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 105 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,516,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SP
TYPE OF TEST : Unscheduled DNA synthesis TEST SYSTEM : Human Cells - not otherwise specified DOSE/DURATION : 1 nmol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 43,2664,1983
TYPE OF TEST : DNA inhibition TEST SYSTEM : Human Cells - not otherwise specified DOSE/DURATION : 10 nmol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 43,2664,1983
TYPE OF TEST : DNA inhibition TEST SYSTEM : Rodent - mouse Cells - not otherwise specified DOSE/DURATION : 1 nmol/L REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 36,1782,1986
TYPE OF TEST : DNA inhibition TEST SYSTEM : Rodent - mouse Leukocyte DOSE/DURATION : 10 nmol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 43,2536,1983
TYPE OF TEST : Mutation test systems - not otherwise specified ROUTE OF EXPOSURE : Administration onto the skin TEST SYSTEM : Human DOSE/DURATION : 5000 ppm REFERENCE : ARDEAC Archives of Dermatology. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.82- 1960- Volume(issue)/page/year: 103,39,1971
TYPE OF TEST : Mutation test systems - not otherwise specified ROUTE OF EXPOSURE : Administration onto the skin TEST SYSTEM : Human DOSE/DURATION : 5000 ppm REFERENCE : 26UYA8 "Psoriasis, Procee
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 1 mg/kg SEX/DURATION : female 14-15 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) REFERENCE : CGANE7 Congenital Anomalies. (Nippon Senten Ijo Gakkai, 377-2 Ono-higashi, Osakasayama, Osaka-Fu 589 Japan) V.27- 1987- Volume(issue)/page/year: 35,133,1995
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 450 ug/kg SEX/DURATION : fem
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Human - woman DOSE : 101 mg/kg SEX/DURATION : female 12-29 week(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - gastrointestinal system REFERENCE : AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 162,396,1990
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 900 mg/kg SEX/DURATION : female 11-19 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetal death REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 44,507,1991
