CAS 58-39-9 MFCD00056798-Perphenazine 奋乃静 TAO{mole}

Perphenazine 奋乃静

CAS 58-39-9 MFCD00056798

化学结构图

SMILES: OCCN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1

化学属性

Mol. Formula	C21H26ClN3OS
Mol. Weight	404
Appearance	白色或类白色结晶性粉末。熔点94-100℃；沸点278-281℃（0.133kPa），214-218℃（0.02kPa）。极易溶于氯仿，溶于乙醇（153mg/ml）、丙酮（82mg/ml），几乎不溶于水。对光敏感，几乎无臭，味微苦。
Melting Point	95.0 to 99.0 deg-C

别名和识别编码

Chemical Name	Perphenazine
CAS Number	58-39-9
Synonym	######## 1',1-(2-Idrossietil)-4,3-(2-cloro-10-fenotiazil)propilpiperazina 1-(2-Hydroxyethyl)-4-(3-(2-chloro-10-phenothiazinyl)propyl)piperazine 1-Piperazineethanol, 4-[3-(2-Chlorophenothiazin-10-yl)propyl]- 1’,1-(2-idrossietil)-4,3-(2-cloro-10-fenotiazil)propilpiperazina 2-Chloro-10-(3-(4-(2-hydroxyethyl)piperazin-1-yl)propyl)phenothiazine 2-Chloro-10-3-(1-(2-hydroxyethyl)-4-piperazinyl)propyl phenothiazine 2-chloro-10-3-(1-(2-hydroxyethyl) 2-chloro-10-[3-[1-(2-hydroxyethyl)-4-piperazinyl]propyl]phenothiazine 4-(3-(2-chlorophenothiazin-10-yl)propyl)-1-piperazineethano 4-[3-(2-chloro-10h-phenothiazin-10yl)propyl]-1-piperazineethano Chlorperphenazine Decentan Etaperazine PERPHENAZINE Perfenazina Trifaron chlorpiprazine
MDL Number	MFCD00056798
PubChem Substance ID	253660321
EC Number	200-381-5
Chemical Name Translation	奋乃静
Reaxys-RN	54730
Merck Number	7183
Wiswesser Line Notation	T C666 BN ISJ EG B3- AT6N DNTJ D2Q
LabNetwork Molecule ID	LN00202029
InChI	InChI=1S/C21H26ClN3OS/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2,4-7,16,26H,3,8-15H2

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

分类

{SNA} Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Cancer Metabolism, Cell Signaling and Neuroscience, Dopaminargics - Antagonists, Dopaminergics, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Glutamine Metabolism and Oncogenesis,

产品应用

D2 dopamine receptor antagonist; ?-adrenergic receptor antagonist and ?-receptor agonist; phenothiazine antipsychotic. Inhibits glutamate dehydrogenase in vitro. Antipsychotic.

安全信息

WGK Germany3

GHS Symbol

Precautionary statements

P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P301+P312+P330
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H302 Harmful if swallowed 吞食有害
H317 May cause an allergic skin reaction 可能导致皮肤过敏

Signal word Warning

Safety Statements

S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；

Hazard Codes Xn

Risk Statements

R22 Harmful if swallowed 吞咽有害
R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应

Storage condition 0-10°C 2-8°C

RTECSTL7175000

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 120 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes,
   C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973
   Volume(issue)/page/year: -,18

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 35 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - convulsions or effect on seizure threshold
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 10,638,1960

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >20 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 11,932,1961

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >80 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Leukocyte
DOSE/DURATION           : 270 mg/kg
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   3,634,1969

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 30 mg/kg
SEX/DURATION            : female 10-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   TOIZAG Toho Igakkai Zasshi.  Journal of Medical Society of Toho University.
   (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143,
   Japan)  V.1-    1954-  Volume(issue)/page/year: 28,621,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 150 mg/kg
SEX/DURATION            : female 10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
   ABAHAU Acta Biologica Academiae Scientiarum Hungaricae.  (Budapest, Hungary)
    V.1-33, 1950-82.  For publisher information, see ABHUE6.
   Volume(issue)/page/year: 27,15,1976

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 70 mg/kg
SEX/DURATION

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 4 mg/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   FESTAS Fertility and Sterility.  (American Fertility Soc., 608 13th Ave. S,
   Birmingham, AL 35282) V.1-    1950-  Volume(issue)/page/year: 12,346,1961

TYPE

其他信息

类别:有毒物质
毒性分级:高毒
MOL 文件:58-39-9.mol
用途一:该品作用与氯丙嗪相似，具有抗精神病、降低体温、止吐和镇静等作用。适用于各类型的精神分裂症，对幻觉、妄想、焦虑、紧张和激动症状有效。亦可用于恶心、呕吐、呃逆及由焦虑、激动引起的失眠等。
急性毒性:口服- 大鼠 LD50: 318 毫克/ 公斤; 口服- 小鼠 LD50: 120 毫克/ 公斤
上游原料:1-溴-3-氯丙烷 --> 2-氯吩噻嗪 --> 奋乃静
储运特性:库房低温, 通风, 干燥; 与食品原料分开存放
灭火剂:水, 二氧化碳, 干粉, 砂土
方法一:N-（2-羟乙基）哌嗪与1，3-溴氯丙烷缩合得到1-（3-氯丙基）-4-（2-羟乙基）哌嗪。然后，将其与2-氯吩噻嗪缩合，制得奋乃静粗品。用乙酸乙酯重结晶，即得成品。
可燃性危险特性:可燃, 燃烧时分解有毒氯化物, 硫氧化物和氮氧化物气体
Sigma Aldrich:58-39-9(sigmaaldrich)