CAS 979-32-8 MFCD00056541-Β-Estradiol 17-Valerate 17-戊酸-β-雌二醇酯 TAO{mole}

Β-Estradiol 17-Valerate 17-戊酸-β-雌二醇酯

CAS 979-32-8 MFCD00056541

化学结构图

SMILES: CCCCC(=O)O[C@H]1CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@]12C

化学属性

Mol. Formula	C23H32O3
Mol. Weight	357
Melting Point	146-150
Solubility	Soluble in ethanol, chloroform, methanol, water (3.6 mg/L at 27 °C), and DMSO (71 mg/mL at 25 °C).

别名和识别编码

Chemical Name	Β-Estradiol 17-Valerate
CAS Number	979-32-8
Synonym	######## β-雌二醇 17-戊酸酯 1,3,5(10)-ESTRATRIEN-3,17-BETA-DIOL 17-VALE 1,3,5(10)-Estratriene-3,17-diol 17-pentanote 1,3,5(10)-雌三烯-3,17β-二醇 17-戊酸酯 1,3,5(10)-Estratriene-3,17β-diol 17-pentanote 17-戊酸-β-雌二醇酯;1,3,5(10)-雌三烯-3,17β-二醇 17-戊酸酯;戊酸雌二醇 17B-ESTRADIOL VALERATE 17B-ESTRADIOL-17-VALERATE 3,5(10)-triene-3,17-diol(17-beta)-estra-17-pentanoate 3-羟基雌甾-1,3,5(10)-三烯-17b-醇 17-戊酸酯 BETA-ESTRADIOL 17-VALERATE DIHYDROFOLLICULIN VALERATE Deladiol Estradiol 17-beta-valerate Estradiol valerate Estradiol-17-valerate; 1,3,5(10)-Estratriene-3,17b-diol 17-pentanote Femogex Pharlon Progynon-depot deladiol delahormoneunimatic delestrogen dura-estradiol estradiol valerate {} {Ch
MDL Number	MFCD00056541
PubChem Substance ID	13791
Beilstein Registry Number	2480357
EC Number	213-559-2
Reaxys-RN	2480357
Merck Number	3703
Chemical Name Translation	17-戊酸-β-雌二醇酯
Wiswesser Line Notation	L E5 B666TTT&J E1 FOV5 OQ
LabNetwork Molecule ID	LN00836022
InChI	InChI=1S/C23H32O3/c1-3-4-5-22(25)26-21-11-10-20-19-8-6-15-14-16(24)7-9-17(15)18(19)12-13-23(20,21)2/h7,9,14,18-21,24H,3-6,8,10-13H2,1-2H3/t18-,19-,20+,21+,23+/m1/s1

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产品应用

Estradiol (E888000) derivative. An estrogen.

安全信息

WGK Germany3

GHS Symbol

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P308+P313
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H351 Suspected of causing cancer 怀疑致癌
H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害

Hazard Codes T

RTECSKG5793000

Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

Signal word Danger

Safety Statements

S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；

Risk Statements

R60 May impair fertility 可能降低生殖能力
R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害

Storage condition 储存温度-20°C

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 104 mg/kg/2Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 5,1003,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 400 ug/kg/W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   AVBIB9 Advances in the Biosciences.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1967-  Volume(issue)/page/year:
   22/23,359,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 10 mg/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - ovaries, fallopian tubes
   Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
   BIREBV Biology of Reproduction.  (Soc. for the Study of Reproduction, 309 W.
   Clark St., Champaign, IL 61820)  V.1-    1969-  Volume(issue)/page/year:
   31,587,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1 mg/kg
SEX/DURATION            : female 12-19 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
   (e.g., placenta, umbilical cord)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   PTLGAX Pathology.  (Royal College of Pathologists of Australia, 82 Windmill
   St., Sydney, NSW, Australia)  V.1-    1969-  Volume(issue)/page/year:
   5,183,1973

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intracerebral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 3200 ug/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - ovaries, fallopian tubes
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 25,351,1982

其他信息

Estradiol valerate是一种人工合成的酯，用于治疗更年期症状及激素不足。
用途一:用于闭经、更年期综合症，减少乳汁分泌、前列腺癌等。
Sigma Aldrich:979-32-8(sigmaaldrich)
MOL 文件:979-32-8.mol
β-雌二醇 17-戊酸酯