CAS 732-11-6 MFCD00055501-Phosmet 亚胺硫磷 TAO{mole}

Phosmet 亚胺硫磷

CAS 732-11-6 MFCD00055501

化学结构图

SMILES: COP(=S)(OC)SCN1C(=O)c2ccccc2C1=O

化学属性

Mol. Formula	C11H12NO4PS2
Mol. Weight	317
Melting Point	71.9°C
Flash Point	>100 °C
Solubility	微溶于水，溶于多数有机溶剂。
Density	0.791

别名和识别编码

Chemical Name	Phosmet
Synonym	(O,O-Dimethyl-phthalimidiomethyl-dithiophosphate) 0，0-二甲基-S-(酞酰亚胺甲基)二硫 Decemthion Decemthion P-6 Dithiophosphorsäure-O,O-dimethyl-S-phthalimidomethylester ENT 25,705 Fosmet Ftalophos IMIDITHION Imidan Imidan; Phosphorodithioic acid S-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl] O,O-dimethyl ester N-(Mercaptomethyl)phthalimide S-(O,O-dimethyl phosphorothionate) N-(dimethoxyphosphinothioylthiomethyl)phatalimid N-(mercaptomethyl)phthalimide S-(O,O-dimethyl phosphorodithioate) N-(mercaptomethyl)phthalimide S-(O,O-dimethylphosphorodithioate) O,O dimethyl phthalimidomethyl phosphorodithioat O,O-DIMETHYL PHTHALIMIDO-METHYL-PHOSPHOROTHIOLOTHIONATE O,O-Dimethyl 5-(phthalimidomethyl)dithiophosphate O,O-Dimethyl S-phtha
CAS Number	732-11-6
EC Number	211-987-4
Beilstein Registry Number	0264869
MDL Number	MFCD00055501
Chemical Name Translation	亚胺硫磷
Wiswesser Line Notation	T56 BVNVJ C1SPS&O1&O1
PubChem Substance ID	12901
InChI	InChI=1S/C11H12NO4PS2/c1-15-17(18,16-2)19-7-12-10(13)8-5-3-4-6-9(8)11(12)14/h3-6H,7H2,1-2H3

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产品应用

该品是有机磷杀虫、杀螨剂，用于防治水稻三化螟、棉红铃虫、棉红蜘蛛以及卫生害虫和家畜寄生虫。

安全信息

GHS Symbol

WGK Germany3

Hazard Codes Xn;N Xn;N,N,Xn Xn,N

Hazard statements

H301 Toxic if swallowed 吞食有毒
H302 Harmful if swallowed 吞食有害
H302+H312
H312 Harmful in contact with skin 皮肤接触有害
H330 Fatal if inhaled 吸入致命
H332 Harmful if inhaled 吸入有害
H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
H370 Causes damage to organs 导致器官损伤
H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

RTECSTE2275000

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P203
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P264+P265
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P284 Wear respiratory protection.? 佩戴呼吸保护装置。
P301+P310
P301+P312
P301+P316
P301+P317
P302+P317
P302+P352
P304+P312
P304+P340
P304+P340+P310
P305+P351+P338
P307+P311
P308+P313
P308+P316
P309+P311
P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
P316
P317
P318
P319
P320 Specific treatment is urgent (see … on this label). 紧急具体治疗（见本标签上的）。
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
P330 Rinse mouth. 漱口
P332+P313
P332+P317
P337+P313
P337+P317
P362+P364
P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
P403+P233
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word Danger Warning

Safety Statements

S22 Do not breathe dust 不要吸入粉尘；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；

Risk Statements

R21/22 Harmful in contact with skin and if swallowed 皮肤接触和不慎吞咽有害
R50/53

UN Number 2811 UN 2811

Packing GroupIII

Hazard Class6.1(b)

Storage condition 0-6°C

Warnings 危化品目录(2015) 危险化学品

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1326 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
   Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
   GKNT, 1982  Volume(issue)/page/year: -,59,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >3160 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd,
   eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year:
   A325,1983

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   SPEADM Special Publication of the Entomological Society of America.  (4603
   Calvert Rd., College Park, MD 20740)  Volume(issue)/page/year: 74-1,-,1974

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 132 mg/kg
TOXIC EFFECTS :
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - true cholinesterase
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 35(12),94,19

TYPE OF TEST            : LD50

TYPE OF TEST            : Gene conversion and mitotic recombination
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 25000 ppm
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 302,153,1993

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 1 pph
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 302,153,1993

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 63466 ug/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   20,73,1992

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Embryo
DOSE/DURATION           : 7933 ug/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  V

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 500 ug/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 302,153,1993

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 20 mg/kg
REFERENCE :
   SOGEBZ Soviet Genetics.  English translation of GNKAA5.  (Plenum Pub. Corp.,
   233 Spring St., New York, NY 10013)  V.2-    1966- Volume(issue)/page/year:
   11,1534,1975

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 49600 ug/kg
SEX/DURATION            : female 1-8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   AXVMAW Archiv fuer Experimentelle Veterinaermedizin.  (S. Hirzel Verlag,
   Postfach 506, Leipzig DDR-7010, Ger. Dem. Rep.)  V.6-    1952-
   Volume(issue)/page/year: 34,791,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 124 mg/kg
SEX/DURATION            : female 1-8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
REFERENCE :
   AXVMAW Archiv fuer Experimentelle Veterinaermedizin.  (S. Hirzel Verlag,
   Postfach 506, Leipzig DDR-7010, Ger. Dem. Rep.)  V.6-    1952-
   Volume(issue)/page/year: 34,791,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 6 mg/kg
SEX/DURATION            : female 1-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - parturition
REFERENCE :
   VETNAL Veterinariya.  Veterinary Science.  (V/O Mezhdunarodnaya Kniga,
   113095 Moscow, USSR) V.1-    1924-  Volume(issue)/page/year: 56(1),62,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 6200 ug/kg
SEX/DURATION            : female 12 day(

其他信息

灭火剂:砂土、干粉、泡沫
用途二:广谱性有机磷杀虫剂，具有触杀和胃毒作用，对植物组织有一定的渗透性。用于水稻、棉花、果树等作物。可防治棉铃虫、棉红蜘蛛、红铃虫、稻叶蝉、稻飞虱、稻纵卷叶螟，用25%乳油22.5～30mL/100m 2 ,对水7.5～11.3kg喷雾。防治棉蚜、菜蚜，用25%乳油7.5～15mL/100m 2 ，对水7.5～11.3kg喷雾。防治苹果叶螨、柑橘介壳虫，用25%乳油600～1000倍液喷雾。防治地老虎，在幼虫3龄期进行防治，用25%乳油加水稀释至250倍烧根。
用途一:属有机磷杀虫、杀螨剂，用于防治水稻三化螟、棉红铃虫、棉红蜘蛛以及卫生害虫和家畜寄生虫
急救治疗:[1]用阿托品1～5mg皮下或静脉注射(按中毒轻重而定) [2]用解磷定0.4－1.2g 静脉注射(按中毒轻重而定) [3]禁用吗啡、茶硷、吩噻嗪、利血平。 [4]误服立即引吐、洗胃、导泻(清醒时才能引吐)。
类别:农药
中毒症状:急性中毒多在12小时内发病，口服立即发病。轻度：头痛、头昏、恶心、呕吐、多汗、无力、胸闷、视力模糊、胃口不佳等，全血胆碱酯酶活力一般降至正常值的70－50%。中度：除上述症状外还出现轻度呼吸困难、肌肉震颤、瞳孔缩小、精神恍惚、行走不稳、大汗、流涎、腹疼、腹泻。重者还会出现昏迷、抽搐、呼吸困难、口吐白沫、大小便失禁，惊厥，呼吸麻痹。
图谱信息:亚胺硫磷(732-11-6)红外图谱(IR2) 亚胺硫磷(732-11-6)红外图谱(IR1) 亚胺硫磷(732-11
毒性分级:剧毒
储运特性:库房通风低温干燥; 与食品原料分开储运
用途三:该品是有机磷杀虫、杀螨剂，用于防治水稻三化螟、棉红铃虫、棉红蜘蛛以及卫生害虫和家畜寄生虫。
方法一:邻苯二甲酰亚胺的制备苯酐与碳酸氢铵作用制得邻苯二甲酰亚胺（简称亚酰胺）。配比为苯酐：碳酸氢铵=1：1.5 （mol)；反应温度280～300℃；操作周期6h。 N-羟甲基苯二甲酰亚胺的制备亚酰胺与甲醛作用制得N-羟甲基苯二甲酰亚胺（简称羟化物）。原料配比为亚酰胺：甲苯=1：1.1，反应温度98～100℃，升温时间1.5h，反应时间3h，操作周期6～7h。氯化甲基苯甲酰亚胺的制备羟化物与盐酸作用制得氯代甲基苯甲酰亚胺（简称氯化物）。原料比为羟化物：盐酸≈1：6.6，升温时间40～50min，反应温度（60±2）℃。加苯温度55～58℃，盐酸含量35%，操作周期6h。 O,O-二甲苯硫代磷酸诼钠盐制备详见乐果的制备方法。亚胺硫磷的合成 O，O-二甲基硫代磷酸钠与氯代甲基苯甲酰亚胺作用，制得亚胺硫磷
上游原料:苄基氯 --> 碳酸氢铵 --> 五硫化二磷 --> 二甲基硫 --> 甲醛水溶液 --> 氯化物 --> 邻苯二甲酰亚胺 --> 乐果 --> 邻苯二甲酸 --> 二甲基二硫代磷酸酯 --> 硫代磷酸钠
毒性:大鼠急性经口LD 50 为147mg/kg（原药为230～299mg/kg)，鼷鼠急性经口LD 50 为34mg/kg，小鼠急性经口LD 50 为45mg/kg。兔急性经皮LD 50 >3160ng/kg，小鼠急性经皮LD 50 >1000mg/kg。大鼠及狗慢性无作用剂量为40mg/kg。对鱼类中等毒性，鲤鱼LC 50 为5.3mg/L。对蜜蜂LD 50 为18.1μg/只。
方法二:由O,O-二甲基二硫代磷酸酯与氯甲基苯二甲酰亚胺反应制得。中间体氯甲基苯二甲酰亚胺的制法：将邻苯二甲酸与20%氨水缓慢加热，温度上升至110-120℃时有大量水分蒸发。反应物用热水处理，得白色结晶邻苯二甲酰亚胺，将其与12%甲醛水溶液加热回流反应2.5h，冷却、过滤、水洗、干燥，得羟甲基苯二甲酰亚胺，而后用30-36%盐酸在甲苯中氯化，在60℃保温2h，得氯甲基苯二甲酰亚胺。原料消耗定额：苯酐（99%）700kg/t、氨水（25%）420kg/t、甲醇（99.5%）350kg/t、甲醛（30%）500kg/t、盐酸（36%）1230kg/t、碳酸氢钠370kg/t、五硫化二磷560kg/t、苯200kg/t。
产品特性:低毒广谱二硫代磷酸酯类杀虫杀螨剂。对高等动物毒性较低，对鱼类毒性中等，对蜜蜂有毒。