CAS 51022-70-9 MFCD00055200-Albuterol sulfate [USAN:USP] 硫酸沙丁胺醇 TAO{mole}

Albuterol sulfate [USAN:USP] 硫酸沙丁胺醇

CAS 51022-70-9 MFCD00055200

化学结构图

SMILES: CC(C)(C)NCC(O)C1C=CC(O)=C(CO)C=1.OS(O)(=O)=O

化学属性

Mol. Formula	C13H21NO3.1/2H2O4S
Mol. Weight	288.35
TSCA	No
Density	1.436
Melting Point	180°C

别名和识别编码

Chemical Name	Albuterol sulfate [USAN:USP]
Synonym	疑甲叔丁肾上腺素硫酸舒喘灵 Salbutamol sulfate Albuterol sulfate α1-[(叔丁基氨基)甲基]-4-羟基-1,3-苯二甲醇半硫酸盐沙丁胺醇半硫酸盐硫酸舒喘灵 Salbutamol hemisulfate salt Salbutamol hemisulfate 阿布叔醇硫酸沙丁胺醇 alpha-[(tert-Butylamino)methyl]-4-hydroxy-m-xylene-alpha,alpha-diol; Albuterol 沙丁胺醇硫酸盐 1-(4-Hydroxy-3-hydroxymethylphenyl)-2-(tert-butylamino)ethanol sulfate
MDL Number	MFCD00055200
CAS Number	51022-70-9
EC Number	256-916-8
PubChem Substance ID	24870399
Chemical Name Translation	硫酸沙丁胺醇
InChIKey	BNPSSFBOAGDEEL-UHFFFAOYSA-N
Wiswesser Line Notation	Q1R BQ EYQ1MX1&1&1 2 &..H2.S-O4

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产品应用

β2-肾上腺素能受体激动剂。其机制为激活腺苷环化酶，促进环磷腺苷生成。

安全信息

WGK Germany2

RTECSCZ6430100

Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

Safety Statements

S36 Wear suitable protective clothing 穿戴适当的防护服；

Risk Statements

R22 Harmful if swallowed 吞咽有害

Hazard Codes Xn

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 13300 mg/kg/95W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Reproductive - Tumorigenic effects - ovarian tumors
   Tumorigenic - tumor types after systemic administration not seen
   spontaneously
REFERENCE :
   JACTDZ Journal of the American College of Toxicology.  (Mary Ann Liebert,
   Inc., 1651 Third Ave., New York, NY 10128)  V.1-12, 1982-1993. Discontinued.
    Volume(issue)/page/year: 12,13,1993

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 48700 ug/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 2,128,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 295 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 2,128,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 2,128,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1950 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(is

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1 gm/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 22,191,1981