8-Cyclopentyl-1,3-Dimethyl-1H-Purine-2,6(3H,7H)-Dione 8-环戊基-1,3-二甲基-1H-嘌呤-2,6(3H,7H)-二酮
CAS 35873-49-5 MFCD00055116
化学结构图
SMILES: CN1C(=O)C2NC(=NC=2N(C)C1=O)C1CCCC1
化学属性
| Mol. Formula | C12H16N4O2 |
|---|---|
| Mol. Weight | 248.28 |
| TSCA | No |
| Melting Point | 250-252° |
别名和识别编码
| Chemical Name | 8-Cyclopentyl-1,3-Dimethyl-1H-Purine-2,6(3H,7H)-Dione |
|---|---|
| CAS Number | 35873-49-5 |
| Synonym | NSC 101806 8-Cyclopentyl-1,3-dimethylxanthine 1H-Purine-2,6-dione, 8-cyclopentyl-3,7-dihydro-1,3-dimethyl- Xanthine, 8-cyclopentyl-1,3-dimethyl- 8-Cyclopentyl-3,9-dihydro-1,3-dimethyl-1H-purine-2,6-dione 8-Cyclopentyl theophylline 8-Cyclopentyltheophylline CPT, NSC 101806 8-Cyclopentyltheophylline CPT |
| MDL Number | MFCD00055116 |
| PubChem Substance ID | 24277730 |
| Chemical Name Translation | 8-环戊基-1,3-二甲基-1H-嘌呤-2,6(3H,7H)-二酮 |
| Wiswesser Line Notation | T56 BM DN FNVNVJ F1 H1 C- AL5TJ |
| Beilstein Registry Number | 1133199 |
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现货库存
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分类
- Heterocycles
- {SNA} Adenosines/P2 Nucleotide Receptor - Antagonists, Adenosines/P2 Nucleotide Receptors (Purinergics), Antagonists, Bioactive Small Molecules, Biochemicals and Reagents, CI-CY, Cell Biology, Cell Signaling and Neuroscience, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitters, Proteins and Derivatives
- Neurochemicals
- Inhibitors
- {SNA} Adenosines/P2 Nucleotide Receptor - Antagonists, Adenosines/P2 Nucleotide Receptors (Purinergics), Antagonists, Bioactive Small Molecule Alphabetical Index, CI-CZ, GPCR Modulators, GPCR Proteins, Modulators and Antibodies,
产品应用
- A selective A1 adenosine receptor antagonist. Binding activity in rat brain membranes: Ki = 10.9 nM (A1 receptor); Ki = 1440 nM (A2 receptor).
相关文献及参考
- Klaasse, E., et al.: Eur. J. Pharmacol., 499, 91 (2004),
- [1]. K A Jacobson, et al. Sulfur-containing 1,3-dialkylxanthine derivatives as selective antagonists at A1-adenosine receptors. J Med Chem. 1989 Aug;32(8):1873-9.
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 14,1202,1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 18 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#06862
