1-Methyl-4-phenylpyridin-1-ium iodide 1-甲基-4-苯基吡啶离子
CAS 36913-39-0 MFCD00055096
化学结构图
SMILES: [I-].C[N+]1C=CC(=CC=1)C1C=CC=CC=1
化学属性
| Mol. Formula | C12H12IN |
|---|---|
| Mol. Weight | 297.13 |
别名和识别编码
| Chemical Name | 1-Methyl-4-phenylpyridin-1-ium iodide |
|---|---|
| CAS Number | 36913-39-0 |
| Synonym | 1-Methyl-4-phenylpyridinium Iodide 1-Methyl-4-phenylpyridinium iodide MPP+ Iodide MPP+ iodide |
| MDL Number | MFCD00055096 |
| PubChem Substance ID | 24893235 |
| Chemical Name Translation | 1-甲基-4-苯基吡啶离子 |
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分类
- Mutagenesis Research Chemicals
- Heterocycles
- Neurochemicals
- {SNA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Dopaminergics, M, Neuroscience, Neurotransmission, Neurotransmitters, Others
- {SNA} Bioactive Small Molecule Alphabetical Index, Dopaminergics, M, Neuroscience, Neurotransmission, Neurotransmitters,
- {SNA} Bioactive Small Molecule Alphabetical Index, Dopaminergics, M, Neuroscience, Neurotransmission, Neurotransmitters, Other Dopaminergics, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
产品应用
- Dopaminergic neurotoxin; a selective cytostatic agent in small-cell lung cancer cell lines with neuroendocrine properties.
相关文献及参考
- [2]. Martí Y, et al. Methyl-4-phenylpyridinium (MPP+) differentially affects monoamine release and re-uptake in murine embryonic stem cell-derived dopaminergic and serotonergic neurons. Mol Cell Neurosci. 2017;83:37-45.
- [3]. Charlton CG. 1-Methyl-4-phenylpyridinium (MPP+) but not 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) serves as methyl donor for dopamine: a possible mechanism of action. J Geriatr Psychiatry Neurol. 1992;5(2):114-118.
- Marini, A.M. et al.: J, Nat. Cancer Inst., 84, 1582 (1992); Singh, M. et al.: Arch. Biochem. Biophys., 286, 138 (1991); Santiago, M. et al.: J. Neurosci. Meth., 108, 181 (2001);
- [1]. Zhao M, et al. Mitochondrial calcium dysfunction contributes to autophagic cell death induced by MPP+ via AMPK pathway. Biochem Biophys Res Commun. 20
- [1]. Zhao M, et al. Mitochondrial calcium dysfunction contributes to autophagic cell death induced by MPP+ via AMPK pathway. Biochem Biophys Res Commun. 2019;509(2):390-394.
安全信息
GHS Symbol
- P301+P310
- P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H331 Toxic if inhaled 吸入中毒
- H311 Toxic in contact with skin 皮肤接触中毒
- H301 Toxic if swallowed 吞食有毒
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H319 Causes serious eye irritation 严重刺激眼睛
- H301+H311+H331
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R25 Toxic if swallowed 吞咽有毒
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 22300 ug/kg TOXIC EFFECTS : Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - somnolence (general depressed activity) Gastrointestinal - changes in structure or function of salivary glands REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 247,531,1988
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 29 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 27,723,1993
