Mianserin Hydrocloride 盐酸米安色林
CAS 21535-47-7 MFCD00055072
化学结构图
SMILES: Cl.CN1CCN2C(C1)C1=CC=CC=C1CC1C=CC=CC2=1
化学属性
| Mol. Formula | C18H20N2· HCl |
|---|---|
| Mol. Weight | 300.83 |
| TSCA | No |
别名和识别编码
| Chemical Name | Mianserin Hydrocloride |
|---|---|
| CAS Number | 21535-47-7 |
| Synonym | Bolvidon; 1,2,3,4,10,14b-Hexahydro-2-methyl-dibenzo[c,f]pyrazino[1,2-a]azepine hydrochloride Bolvidon 1,2,3,4,10,14b-Hexahydro-2-methyldibenzo(c,f)pyrazino(1,2-a)azepine 米赛林 盐酸盐 1,2,3,4,10,14b-Hexahydro-2-methyldibenzo[c,f]pyrazino[1,2-a]azepine Hydrochloride GB 94 Athymil Lantanon 1,2,3,4,10,14b-六氢-2-甲基-二苯并[c,f]吡嗪并[1,2-a]氮杂卓 盐酸盐 |
| MDL Number | MFCD00055072 |
| PubChem Substance ID | 24278125 |
| EC Number | 244-426-7 |
| Merck Number | 14,6172 |
| Chemical Name Translation | 盐酸米安色林 |
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分类
- Pharmaceuticals
- {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Bioactive Small Molecules, Cell Biology, M,
- Heterocycles
- {SNA} Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, M, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitters, Organon, Serotonergics, Serotonergics - Antagonists, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 蛋白质及衍生物
- Intermediates & Fine Chemicals,
产品应用
- Serotonin receptor antagonist. Antidepressant.
相关文献及参考
- [2]. Roeder T. High-affinity antagonists of the locust neuronal octopamine receptor. Eur J Pharmacol. 1990 Nov 27;191(2):221-4.
- Brogden, R.N., et al.: Drugs, 16, 273 (1978),
- Saxena, et al.: Eur. J. Pharmacol., 13, 295 (1971),
- [1]. Olianas MC,et al. The atypical antidepressant mianserin exhibits agonist activity at κ-opioid receptors. Br J Pharmacol. 2012 Nov;167(6):1329-41.
- [1]. Olianas MC,et al. The atypical antidepressant mianserin exhibits agonist activity at κ-opioid receptors. Br J Pharmacol. 2012 Nov;167(6):1329-41.
- [2]. Roeder T. High-affinity antagonists of the locust neuronal octopamine receptor. Eur J Pharmacol. 1990 Nov 27;191(2):221-4.
安全信息
GHS Symbol
- H302 Harmful if swallowed 吞食有害
- R22 Harmful if swallowed 吞咽有害
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 18 mg/kg TOXIC EFFECTS : Behavioral - coma Cardiac - pulse rate Cardiac - other changes REFERENCE : HUTODJ Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants., RG 21 2XS, UK) V.1- 1981- Volume(issue)/page/year: 6,401,1987
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 262 mg/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - changes in motor activity (specific assay) REFERENCE : SKKNAJ Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. (Sankyo K.K. Sogo Kenkyusho, 1-2-58 Hiro-machi, Shinagawa-ku, Tokyo 140, Japan) No.15- 1963- Volume(issue)/page/year: 31,112,1979
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 28 mg/kg/5W TOXIC EFFECTS : Behavioral - hallucinations, distorted perceptions Cardiac - change in rate Lungs, Thorax, or Respiration - other changes REFERENCE : BMJOAE British Medical Journal. (British Medical Assoc
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >3 gm/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) REFERENCE : SKKNAJ Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. (Sankyo K.K. Sogo Kenkyusho, 1-2-58 Hiro-machi, Shinagawa-ku, Tokyo 140, Japan) No.15- 1963- Volume(issue)/page/year: 31,112,1979
TYPE OF TEST : Specific locus test ROUTE OF EXPOSURE : Oral TEST SYSTEM : Insect - Drosophila melanogaster DOSE/DURATION : 100 mmol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 286,155,1993
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 5 mg/kg SEX/DURATION : female 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - other measures of fertility REFERENCE : DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 7,41,1984
