4-Benzamido-5-(Dipropylamino)-5-Oxopentanoic Acid 丙谷胺

CAS 6620-60-6 MFCD00055071

化学结构图

6620-60-6
SMILES: CCCN(CCC)C(=O)C(CCC(=O)O)NC(=O)c1ccccc1

化学属性

Mol. FormulaC18H26N2O4
Mol. Weight334.46
Appearance 无色结晶或结晶性粉末。熔点142-145℃，易溶于乙醇、甲醇、氯仿，难溶于丙酮、水、苯，几乎不溶于四氯化碳。无臭，味苦。

别名和识别编码

Chemical Name4-Benzamido-5-(Dipropylamino)-5-Oxopentanoic Acid
CAS Number6620-60-6
Synonym ######## (+-)-pentanoicaci (+/-)-4-Benzamido-N,N-dipropylglutaramic acid (+/-)-4-benzamido-n,n-dipropylglutaramic acid (+/-)-5-二丙基氨基-4-苯甲酰氨基-5-氧代戊酸 (±)-5-二丙基氨基-4-苯甲酰氨基-5-氧代-戊酸 242 DL 242dl Binoside CR 242 DL-4-Benzamido-N,N-dipropylglutaramic acid Gastrotopic KXM LABOTEST-BB LT00772215 Midelid Milid Milide Nulsa PROGLUMIDE Pentanoic acid, 4-(benzoylamino)-5-(dipropylamino)-5-oxo-, (+-)- Proglumide Promide (parasympatholytic) Ulcutin W 5219 Xilamide Xyde Xylamide Xylamide (gastroprotective agent) binoside cr242 dl-4-benzamido-n,n-dipropylglutaramicacid
EC Number229-567-4
Chemical Name Translation丙谷胺
MDL NumberMFCD00055071
Beilstein Registry Number4151696
LabNetwork Molecule IDLN01306638
PubChem Substance ID4922
InChIInChI=1S/C18H26N2O4/c1-3-12-20(13-4-2)18(24)15(10-11-16(21)22)19-17(23)14-8-6-5-7-9-14/h5-9,15H,3-4,10-13H2,1-2H3,(H,19,23)(H,21,22)
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分类

  • Amines
  • Aromatics
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Anticholinergic.

相关文献及参考

  • [2]. Iwamoto Y, et al. In vitro and in vivo effect of proglumide on cholecystokinin-stimulated amylase release in mouse pancreatic acini. Gastroenterol Jpn. 1984 Feb;19(1):53-8.
  • [3]. González-Puga C, et al. Selective CCK-A but not CCK-B receptor antagonists inhibit HT-29 cell proliferation: synergism with pharmacological levels of melatonin. J Pineal Res. 2005 Oct;39(3):243-50.
  • [4]. Bunney BS, et al. Further studies on the specificity of proglumide as a selective cholecystokinin antagonist in the central nervous system. Ann N Y Acad Sci. 1985;448:345-51.
  • [5]. Tariq M, et al. Gastric and duodenal antiulcer and cytoprotective effects of proglumide in rats. J Pharmacol Exp Ther. 1987 May;241(2):602-7.
  • Umetzu, T., et al.: Eur. J. Pharmacol., 64, 69 (1980),
  • [1]. Ahmad M, et al. The effects of quinacrine, proglumide, and pentoxifylline on seizure activity, cognitive deficit, and oxidative stress in rat lithium-pilocarpine model of status e

安全信息

RTECSMA2805000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1480 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YAKUD5 Gekkan Yakuji.  Pharmaceuticals Monthly.  (Yakugyo Jihosha, Inaoka
   Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan)  V.1-   1959-
   Volume(issue)/page/year: 20,447,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1420 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YAKUD5 Gekkan Yakuji.  Pharmaceuticals Monthly.  (Yakugyo Jihosha, Inaoka
   Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan)  V.1-   1959-
   Volume(issue)/page/year: 20,447,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >5190 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Endocrine - other changes
   Skin and Appendages - corrosive (after topical exposure)
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 5,203,1971

TYPE OF TEST

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MIMEAO Minerva Medica.  (Edizioni Minerva Medica, Casella Postale 491,
   I-10126 Turin, Italy) V.1-    1909-  Volume(issue)/page/year: 58,3653,1967

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TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 5400 mg/kg
SEX/DURATION            : female 7-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 5,225,1971

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1350 mg/kg
SEX/DURATION            : female 9-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 5,225,1971

其他信息

  • 可燃性危险特性:可燃; 燃烧产生有毒氮氧化物烟雾
  • 用途一:该品为胃泌素受体拮抗剂，具有胃粘膜保护作用，促进溃疡愈合。适用于胃及十二指肠溃疡、胃炎、应激性溃疡等，有效率达81-96%，应用本品不发生胃酸反跳性增多，且复发率低。
  • 上游原料:苯甲酰氯 --> 二正丙胺
  • 毒性分级:中毒
  • 急性毒性:腹腔-大鼠 LD50: 1420 毫克/公斤; 口服-小鼠 LD50: 8070 毫克/公斤
  • 储运特性:通风低温干燥
  • MOL 文件:6620-60-6.mol
  • 类别:有毒物品
  • 灭火剂:干粉,泡沫,沙土,二氧化碳, 雾状水
  • 方法一:以谷胺酸为起始原料，经与苯甲酰氯反应得N-苯甲酰谷氨酸，然后乙酐反应得N-苯甲酰谷氨酸酐，再与二丙胺进行胺化反应即得丙谷胺。以谷氨酸计，总收率26-30%。

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. Cholecystokinin Receptor  (胆囊收缩素受体)

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