CAS 759-73-9 MFCD00053635-N-Nitroso-N-Ethylurea N-亚硝基-N-乙基脲 TAO{mole}

N-Nitroso-N-Ethylurea N-亚硝基-N-乙基脲

CAS 759-73-9 MFCD00053635

化学结构图

SMILES: CCN(N=O)C(N)=O

化学属性

Mol. Formula	C3H7N3O2
Mol. Weight	117
Melting Point	103-1040C (dec)

别名和识别编码

Chemical Name	N-Nitroso-N-Ethylurea
CAS Number	759-73-9
Synonym	1-(Aminocarbonyl)-1-ethyl-2-oxohydrazine 1-ETHYL-1-NITROSOUREA 1-Ethyl-1-nitrosomocovina 1-Ethyl-1-nitrosourea 1-NITROSO-1-ETHYLUREA 1-ethyl-1-nitroso-ure 1-乙基-1-亚硝基脲 AENH Aenh Aethylnitroso-harnstoff Carbamide, N-ethyl-N-nitroso- ENU ENU N-Ethyl-N-nitrosourea Ethylnitrosourea N-ETHYL-N-NITROSOUREA N-Ethyl-N-nitroso-urea N-Ethyl-N-nitrosourea N-Ethylnitrosourea N-NITROSO-N-ETHYLUREA N-NITROSOETHYLUREA N-Nitroso-N-ethylurea N-亚硝基-N-乙基脲 NEU NSC 45403 Nitrosoethylurea RCRA waste number U176 anh n-ethyl-n-nitroso-carbamid n-ethyl-n-nitroso-ure
MDL Number	MFCD00053635
PubChem Substance ID	24897681
EC Number	212-072-2
Chemical Name Translation	N-亚硝基-N-乙基脲
Wiswesser Line Notation	ZVN2&NO
Beilstein Registry Number	1761174
LabNetwork Molecule ID	LN00193007

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产品应用

Precursor of Diazoethane

安全信息

WGK Germany3

GHS Symbol

Precautionary statements

P301+P310
P308+P313
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P201 Obtain special instructions before use. 使用前获取专门指示。

Hazard statements

H332 Harmful if inhaled 吸入有害
H350 May cause cancer 可能致癌
H312 Harmful in contact with skin 皮肤接触有害
H301 Toxic if swallowed 吞食有毒
H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害

RTECSYT3150000

Signal word Danger

Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

Hazard Codes T

Safety Statements

S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S22 Do not breathe dust 不要吸入粉尘；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；

Risk Statements

R46 May cause inheritable genetic damage 可能引起遗传基因损害
R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
R45 May cause cancer 可能致癌
R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害

Packing GroupIII

Storage condition -20°C 储存温度-20°C

Hazard Class6.1(b)

UN Number UN 2811 6.1/PG 3

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 374 mg/kg/2W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Blood - leukemia
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(iss

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 45 mg/kg
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Brain and Coverings - tumors
   Skin and Appendages - tumors
REFERENCE :
   ANTRD4 Anticancer Research.  (5 Argyropoulou St., Kato Patissia, Athens 907,
   Greece)  V.1-    1981-  Volume(issue)/page/year: 4,5,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 10 mg/kg
                          female 19 day(s) after conception
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Reproductive - Tumorigenic effects - transplacental tumorigenesis
   Brain and Coverings - tumors
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   2,93,1976

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5 mg/kg
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 6,769,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kil

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 240 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 222,1064,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 960 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 223,377,1989

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 240 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZEKBAI Zeitschrift fuer Krebsforschung.  (Berlin, Fed. Rep. Ger.)  V.1-75,
   1903-71.  For publisher information, see JCROD7.  Volume(issue)/page/year:
   74,141,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 490 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 223,377,1989

TYPE OF TEST            : Specific locus test
ROUTE OF EXPOSURE       : Multiple routes
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 300 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 122,123,1983

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 200 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   48,3100,1988

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TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 25 umol/L
REFERENCE :
   MOPMA3 Molecular Pharmacology.  (Williams & Wilkins Co., 42

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - rat Cells - not otherwise specified
DOSE/DURATION           : 200 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   48,3100,1988

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Inhalation
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 16 mg/L/47H
REFERENCE :
   SOGEBZ Soviet Genetics.  English translation of GNKAA5.  (Plenum Pub. Corp.,
   233 Spring St., New York, NY 10013)  V.2-    1966- Volume(issue)/page/year:
   10,1172,1974

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 200 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amste

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 440 mg/kg
SEX/DURATION            : female 7-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - uterus, cervix, vagina
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 23,981,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 125 mg/kg
SEX/DURATION            : female 7-16 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetal death
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD
   Pub. Ltd., P.O. Box 966, Westbury, NY 11590)  V.1-    1970-
   Volume(issue)/page/year: 41,265,1983

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 50 mg/kg
SEX/DURATION            : female 20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
   JONRA9 Journal of Neurochemistry.  (Raven Press, 1185 Ave. of the Americas,
   New York, NY 10036) V.1-    1956-  Volume(issue)/page/year: 29,771,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - ra

其他信息

MOL 文件:759-73-9.mol
Sigma Aldrich:759-73-9(sigmaaldrich)