N-(3-(2,4-Dichlorophenoxy)Propyl)-N-Methylprop-2-Yn-1-Amine Hydrochloride N-[3-(2,4-二氯苯氧基)丙基]-N-甲基-2-丙炔胺盐酸盐
CAS 17780-75-5 MFCD00052012
化学结构图
SMILES: Cl.CN(CC#C)CCCOC1=CC=C(Cl)C=C1Cl
化学属性
| Mol. Formula | C13H15Cl2NO · HCl |
|---|---|
| Mol. Weight | 308.63 |
别名和识别编码
| Chemical Name | N-(3-(2,4-Dichlorophenoxy)Propyl)-N-Methylprop-2-Yn-1-Amine Hydrochloride |
|---|---|
| Synonym | Clorgyline Clorgyline hydrochloride M&B 9302 N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride N-甲基-N-丙炔基-3-(2,4-二氯苯氧基)丙胺盐酸盐 |
| MDL Number | MFCD00052012 |
| PubChem Substance ID | 24278179 |
| CAS Number | 17780-75-5 |
| EC Number | 241-760-5 |
| Chemical Name Translation | N-[3-(2,4-二氯苯氧基)丙基]-N-甲基-2-丙炔胺盐酸盐 |
| Wiswesser Line Notation | GR CG DO3N1&2UU1 &GH |
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分类
- {SA} Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, L to O, M, Monoamine Oxidase A, Mono
- {SNA} Bioactive Small Molecule Alphabetical Index, Enzyme Inhibitors,
相关文献及参考
- Inoue, H., et al., Species-dependent differences in monoamine oxidase A and B-catalyzed oxidation of various C4 substituted 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridinyl derivatives. J. Pharmacol. Exp. Ther. 291 , 856, (1999) 摘要
- Figueiredo, I.V., et al., The role of MAO-A and MAO-B in the metabolic degradation of noradrenaline in human arteries. J. Auton. Pharmacol. 18 , 123-128, (1998) 摘要
- Shih, J.C., et al., Determination of regions important for monoamine oxidase (MAO) A and B substrate and inhibitor selectivities. J. Neural Transm. 52 , 1-8, (1998) 摘要
- Yang, W., et al., Inhibition Of Semicarbazide-sensitive Amine Oxidase Attenuates Myocardial Ischemia-reperfusion Injury In An In Vivo Rat Model. Leuk. Res. 88 , 302-6, (2011) 摘要
安全信息
GHS Symbol
- P301+P310
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- H332 Harmful if inhaled 吸入有害
- H312 Harmful in contact with skin 皮肤接触有害
- H301 Toxic if swallowed 吞食有毒
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcu
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 94 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 17,1285,1968
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 210 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 17,1285,1968
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 62 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 17,1285,1968
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 430 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 17,1285,1968
TYPE OF TEST : LD50
