Methyl 5-Nitro-2-Furoate 5-硝基呋喃-2-甲酸甲酯
CAS 1874-23-3 MFCD00051956
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分类
- {SNA} Building Blocks, C4 to C7, Chemical Synthesis, Furans, Heterocyclic Building Blocks
- {uni_hamburg} no charge; oxygen heterocycle; aromatic; 5ring; ester; 1fragment
相关文献及参考
- Short: IV/20C Title: Vapor Pressure and Antoine Coefficients for Nitrogen Containing Organic Compounds Author: Dykyj, J.; Svoboda, J.; Wilhoit, R.C.; Frenkel, M.; Hall, K.R. Editor: Hall, K.R. Source: Landolt-Börnstein, New Series Volume: IV/20C Year: 2001 Keyword: organic compounds; vapor pressure ISBN: 3-540-41060-0 ISBN: 978-3-540-41060-7 Internet Resource: DOI:10.1007/b88812 RefComment: VII, 197 pages
- Beil. 18 ,287
- The nitro-group is susceptible to nucleophilic displacement (compare 1,4-Dinitrobenzene, A10293): J. Heterocycl. Chem., 18, 1241 (1981). This has been used as the basis of a synthesis of diaryl ethers involving Diels-Alder addition and decarboxylative aromatization of the adduct: J. Chem. Soc., Perkin 1, 1231 (1990):
- Undergoes vicarious nucleophilic substitution of hydrogen at the 3-position. For example with chloromethyl phenyl sulfone and base, 2-nitro-3-(phenylsulfonylmethyl)furan is formed in 75% yield: Tetrahedron, 51, 8339 (1995). For analogous example and reaction scheme, see 2-Nitrothiophene, A17464.
- For a review of vicarious nucleophilic substitution in heterocyclic compounds, see: Synthesis, 103 (1991).
- The nitro-group is susceptible to nucleophilic displacement (compare 1,4-Dinitrobenzene, A10293): J. Heterocycl. Chem., 18, 1241 (1981). This has been used as the basis of a synthesis of diaryl ethers involving Diels-Alder addition and decarboxylative aromatization of the adduct: J. Chem. Soc., Perkin 1, 1231 (1990):
- Undergoes vicarious nucleophilic substitution of hydrogen at the 3-position. For example with chloromethyl phenyl sulfone and base, 2-nitro-3-(phenylsulfonylmethyl)furan is formed in 75% yield: Tetrahedron, 51, 8339 (1995). For analogous example and reaction scheme, see 2-Nitrothiophene, A17464.
- For a review of vicarious nucleophilic substitution in heterocyclic compounds, see: Synthesis, 103 (1991).
安全信息
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
- S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护;
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 5 ug/plate REFERENCE : CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 7,1339,1986
- H302 Harmful if swallowed 吞食有害
- H312 Harmful in contact with skin 皮肤接触有害
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H332 Harmful if inhaled 吸入有害
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
- P203
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P264+P265
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- P301+P317
- P302+P352
- P304+P340
- P305+P351+P338
- P317
- P318
- P319
- P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
- P330 Rinse mouth. 漱口
- P332+P317
- P337+P317
- P362+P364
- P403+P233
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
其他信息
- 上游原料:盐酸 --> 乙醚 --> 二氯甲烷 --> 硝酸 --> 硫酸钠 --> 乙酐 --> 碳酸氢钠 --> N,N-二异丙基乙胺 --> 2-糠酸甲酯
- Acros Organics:Methyl 5-nitro-2-furoate, 97%(1874-23-3)
- 5-硝基-2-糠酸甲酯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 344520250 5-硝基-2-糠酸甲酯 Methyl 5-nitro-2-furoate 97% 25 GR 2418元 2010/06/21 344520050 5-硝基-2-糠酸甲酯 Methyl 5-nitro-2-furoate 97% 5 GR 612元 2010/05/25 A15226 5-甲基-2-糠酸甲酯, 97% Methyl 5-nitro-2-furoate, 97% 5g 630元
- 图谱信息:5-硝基-2-糠酸甲酯(1874-23-3)红外图谱(IR1) 5-硝基-2-糠酸甲酯(1874-23-3)红外图谱(IR2) 5-硝基-2-糠酸甲酯(1874-23-3)质谱(MS)
- MOL 文件:1874-23-3.mol
- Sigma Aldrich:1874-23-3(sigmaaldrich)
- Alfa Aesar:5-甲基-2-糠酸甲酯,97% Methyl 5-nitro-2-furoate, 97%(1874-23-3)
- Hazard Note:Irritant