6-Chloro-3,4-Dihydro-(2H)-1,2,4-Benzothiadiazine-7-Sulfonamide 1,1-Dioxide 6-氯-7-磺酰胺-3,4-二氢-1,2,4-苯并噻二嗪-1,1-二氧化物
CAS 58-93-5 MFCD00051765
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分类
- Analytical Standards, Analytical/Chromatography, Chromatography, Diuretic, Doping Substances, Forensic and Veterinary Standards, Pharmaceutical Secondary Standards, Pharmaceutical Standards
- {SNA} Core Bioreagents, Enzyme Inhibitors, Pharmacopoeia, Pharmacopoeia A-Z, Research Essentials, 分析/色谱
- {uni_hamburg} no charge; sulfur heterocycle; nitrogen heterocycle; carbocycle; aromatic; alicycle; large ring; fused rings; 6ring; 10ring; 1fragment
- {SNA} Bioactive Small Molecules, Cell Biology, Core Bioreagents, Enzyme Inhibitors, H, Pharmacopoeia, Pharmacopoeia A-Z, Research Essentials
产品应用
- A carbonic anhydrase inhibitor. Diuretic.
相关文献及参考
- Piala, J.J., et al.: J. Pharmacol. Exp. Ther., 134, 273 (1961),
- Deppeler, H.P., et al.: Anal. Profiles Drug Subs., 10, 405 (1981),
- Merck 14 ,4781
- Short: III/10a Title: Structure Data of Organic Crystals: C ... C 15 Author: Schudt-Weitz, G.; Strell, I. Editor: Hellwege, K.-H.; Hellwege, A.M. Source: Landolt-Börnstein, New Series Volume: III/10a Year: 1985 ISBN: 3-540-07834-7 ISBN: 978-3-540-07834-0 Internet Resource: DOI:10.1007/b19984 RefComment: XXII, 634 pages. Hardcover Abstract: The volume includes an alphabetical index of all substances and a separate "ring index" with all cyclic compounds.
- Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15
安全信息
GHS Symbol
- H302 Harmful if swallowed 吞食有害
- S7 Keep container tightly closed 保存在严格密闭容器中;
- S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
- S33 Take precautionary measures against static discharges 对静电采取预防措施;
- S22 Do not breathe dust 不要吸入粉尘;
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
- S24 Avoid contact with skin 避免皮肤接触;
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
- R42/43
- R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
- R22 Harmful if swallowed 吞咽有害
- R23/25 Toxic by inhalation and if swallowed 吸入及吞食都有毒
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 309 gm/kg/2Y-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors REFERENCE : NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-357,1989
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 590 mg/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 134,273,1961
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 250 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,124,1973
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TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FRZKAP Farmatsevtichnii Zhurnal (Kiev). (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.3- 1930- Volume(issue)/page/year: (5),26,1983
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1470 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Pre
TYPE OF TEST : Sex chromosome loss and nondisjunction TEST SYSTEM : Mold - Aspergillus nidulans DOSE/DURATION : 1 gm/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 26,159,1974
TYPE OF TEST : DNA adduct TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 5 mg/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981
TYPE OF TEST : Mutation in mammalian somatic cells TEST SYSTEM : Rodent - mouse Lymphocyte DOSE/DURATION : 500 mg/L REFERENCE : NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-357,1989
TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Rodent - hamster Lung DOSE/DURATION : 500 mg/L/48H REFERENCE : GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year: 27,95,1981
TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Rodent - hamster Ovary DOSE/DURATION : 43 mg/L REFERENCE : EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987
其他信息
- 储运特性:库房低温, 通风, 干燥
- 图谱信息:双氢氯噻嗪(58-93-5)红外图谱(IR1) 双氢氯噻嗪(58-93-5)红外图谱(IR2)
- Acros Organics:6-Chloro-1,1-dioxo-1,2,3,4-tetrahydro-1lambda~6~,2,4-benzothiadiazine-7-sulfonamide, 97%(58-93-5)
- 急性毒性:口服- 大鼠 LD50: 2750 毫克/ 公斤; 口服-小鼠 LD50: 1175 毫克/公斤
- MSDS 信息:Hydrochlorothiazide(58-93-5).msds
- 毒性分级:中毒
- 上游原料:3-氯苯胺 --> 4,4'-二氨基苯酰替苯胺
- Alfa Aesar:氢氯噻嗪,98% Hydrochlorothiazide, 98%(58-93-5)
- 方法一:由间氯苯胺经氯磺化得到5-氯-2,4-氯磺酰苯胺,再氨反应生成5-氯-2,4-氨磺苯胺,最后用甲醛歪合制得。
- 双氢氯噻嗪价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 JFD00715EA 双氢氯噻嗪 6-chloro-1,1-dioxo-1,2,3,4-tetrahydro-1lambda~6~,2,4-benzothiadiazine-7-sulfonamide 10 GR 480元 2010/06/21 JFD00715EB 双氢氯噻嗪 6-chloro-1,1-dioxo-1,2,3,4-tetrahydro-1lambda~6~,2,4-benzothiadiazine-7-sulfonamide 25 GR 900元 2010/05/25 B22093 氢氯噻嗪, 98% Hydrochlorothiazide, 98% 25g 955元
- Hazard Note:Irritant
- Sigma Aldrich:58-93-5(sigmaaldrich)
- 可燃性危险特性:可燃; 火场分解有毒氯化氢, 硫氧化物, 氮氧化物气体
- 灭火剂:水, 二氧化碳, 干粉, 砂土
- 类别:有毒物质
- 用途一:该品为噻嗪类中效利尿药的典型代表,在美国1985年药物销售额排第一位。因服用方便,作用中等,且适用于各种水肿,因此是临床上最常因有排钾性不良反应,应用时需补充钾盐。小鼠静永注射LD50为590mg/kg,口服LD50为大于8000mg/kg。
- MOL 文件:58-93-5.mol