Metepa 三(2-甲基氮丙啶)氧化磷

CAS 57-39-6 MFCD00046984

化学结构图

57-39-6
SMILES: CC1CN1P(N1CC1C)N1CC1C

化学属性

Mol. FormulaC9H18N3OP
Mol. Weight215.27
Boiling Point90-92 ºC (0.15-0.3 MMHG)
Solubility可混溶于水多数有机溶剂。

别名和识别编码

Chemical NamePhosphine oxide, tris(2-methyl-1-aziridinyl)-
EC Number200-326-5
CAS Number57-39-6
Synonym 1,1',1''-Phosphinylidynetris(2-methyl)azridine 1,1’,1’’-phosphinylidynetris(2-methyl)azridine 1,1’,1’’-phosphinylidynetris(2-methyl-Aziridine 1,1’,1’’-phosphinylidynetris[2-methyl-aziridin 1,1’,1’’-氧次膦基三(2-甲基氮丙啶) C 3172 ENT 50,003 MAPO MAPO(R) Metapoxide Metepa Methaphoxide Methyl aphoxide N,N',N''-TRIS(1-METHYLETHYLENE)PHOSPHORIMIDE N,N',N''-Tris(1-methylethylene)phosphoramide SALOR-INT L169277-1EA TRIS [1-(2-METHYL)-AZIRIDINYL] PHOSPHINE OXIDE TRIS-(2-METHYL-1-AZIRIDINYL)-PHOSPHINOXIDE Tris(1-methylethylene)phosphoric triamide Tris(2-methyl-1-aziridinyl)-phosphine oxide Tris(2-methyl-1-aziridinyl)phosphine oxide Tris(2-methylaziridin-1-yl)phosphine oxide {Chem
Chemical Name Translation三(2-甲基氮丙啶)氧化磷
Wiswesser Line NotationT3NTJ B1 APO&- AT3NTJ B1&- AT3NTJ B1
Beilstein Registry Number1345447
PubChem Substance ID60976
InChIInChI=1S/C9H18N3OP/c1-7-4-10(7)14(13,11-5-8(11)2)12-6-9(12)3/h7-9H,4-6H2,1-3H3
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安全信息

UN Number 2810
Warnings 危化品目录(2015) 危险化学品 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1000 mg/kg/60W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Brain and Coverings - tumors
   Blood - leukemia
REFERENCE :
   BWHOA6 Bulletin of the World Health Organization.  (WHO, Pub. Center USA, 49
   Sheridan Ave., Albany, NY 12210)  Volume(issue)/page/year: 34,317,1966

RTECSSZ1925000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 136 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   14,515,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 292 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   INHEAO Industrial Health.  (National Institute of Industrial Health, 6-21-1
   Nagao, Tama-ku, Kawasaki, 213 Japan)  V.1-    1963- Volume(issue)/page/year:
   8,54,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 375 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   INHEAO Industrial Health.  (National Institute of Industrial Health, 6-21-1
   Nagao, Tama-ku, Kawasaki, 213 Japan)  V.1-    1963- Volume(issue)/page/year:
   8,54,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 183 mg/kg
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Gastrointestinal - hypermotility, diarrhea
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   BWHOA6 Bulletin of the World Health Organization.  (WHO, Pub. Center USA, 49
   Sheridan Ave., Albany, NY 12210)  Volume(issue)/page/year: 31,737,1964

TYPE OF TEST            : LDLo - Lowest published lethal dose

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 500 ug/plate
REFERENCE :
   CNJGA8 Canadian Journal of Genetics and Cytology.  (National Research
   Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6,
   Canada)  V.1-    1959-  Volume(issue)/page/year: 21,319,1979

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 40 mg/kg/2D
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 26,199,1974

TYPE OF TEST            : Dominant lethal test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   RPZHAW Roczniki Panstwowego Zakladu Higieny.  (Ars Polona, POB 1001, 00-068
   Warsaw 1, Poland) V.1-    1950-  Volume(issue)/page/year: 33,215,1982

{hazard_com

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 20 mg/L
REFERENCE :
   SOGEBZ Soviet Genetics.  English translation of GNKAA5.  (Plenum Pub. Corp.,
   233 Spring St., New York, NY 10013)  V.2-    1966- Volume(issue)/page/year:
   8,783,1972

TYPE OF TEST            : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE       : Administration onto the skin
TEST SYSTEM             : Insect - not otherwise specified
DOSE/DURATION           : 1000 ppm
REFERENCE :
   CYTOAN Cytologia.  (Japan Pub. Trading Co. (USA), 1255 Howard St., San
   Francisco, CA 94103) V.1-    1929-  Volume(issue)/page/year: 38,21,1973

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 30 mg/kg
SEX/DURATION            : female 11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   AEHLAU Archives of Environmental Health.  (Heldref Pub., 4000 Albemarle St.,
   NW, Washington, DC 20016)  V.1-    1960-  Volume(issue)/page/year:
   16,805,1968

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPE

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1 mg/kg
SEX/DURATION            : male 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - male fertility index (e.g. # males impregnating
   females per # males exposed to fertile nonpregnant females)
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
   Reproductive - Effects on Newborn - stillbirth
REFERENCE :
   IJMRAQ Indian Journal of Medical Research.  (Indian Council of Medical
   Research, Ansari Nagar, New Delhi 110 029, India)  V.1-    19

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 25 mg/kg
SEX/DURATION            : male 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   23,288,1972

Hazard statements
  • H301 Toxic if swallowed 吞食有毒
  • H310 Fatal in contact with skin 皮肤接触致命
Precautionary statements
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310
  • P302+P350
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....

其他信息

  • 用途:主要用于导弹药树脂包覆层的交联剂和固化剂，能够增强产品的弹性能和弹道性能，是军工企业中的重要化工原料
  • 外观性质:浅黄色粘稠液体，有氨味。
  • EPA化学物质信息:Aziridine, 1,1',1''-phosphinylidynetris[ 2-methyl-(57-39-6)
  • NIST化学物质信息:Tris(1-(2-methyl)aziridinyl)phosphine oxide(57-39-6)
  • MOL 文件:57-39-6.mol
  • PackingGroup:III
  • HazardClass:6.1(b)

系列性分类

  1. Functional Group 官能团索引
  2. phosphoric acid amide

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