2-Amino-6-((1S,2R)-1,2,3-Trihydroxypropyl)Pteridin-4(3H)-One 2-氨基-6-((1S,2R)-1,2,3-三羟丙基)蝶啶-4(3H)-酮
CAS 2009-64-5 MFCD00042801
化学结构图
SMILES: Nc1nc2ncc([C@H](O)[C@H](O)CO)nc2c(=O)[nH]1
化学属性
| Mol. Formula | C9H11N5O4 |
|---|---|
| Mol. Weight | 253 |
| Solubility | Soluble in DMSO (20 mM, with gentle warming), 0.05M NaOH, 1M HCl, aqueous acid, and water (very slightly). Ultrasonication may improve the dissolution. |
别名和识别编码
| Chemical Name | 2-Amino-6-((1S,2R)-1,2,3-Trihydroxypropyl)Pteridin-4(3H)-One |
|---|---|
| CAS Number | 2009-64-5 |
| Synonym | ######## D-(+)-新蝶呤 D-erythro-Neopterin D-赤型新蝶呤 D-赤型新蝶呤;[S-(R,S*)]-2-氨基-6-(1,2,3-三羟基丙基)-1H- 蝶啶-4-酮;新蝶呤 [S-(R*,S*)]-2-Amino-6-(1,2,3-trihydroxypropyl)-1H-pteridin-4-one |
| MDL Number | MFCD00042801 |
| PubChem Substance ID | 57654449 |
| Beilstein Registry Number | 89070 |
| EC Number | 217-924-7 |
| Chemical Name Translation | 2-氨基-6-((1S,2R)-1,2,3-三羟丙基)蝶啶-4(3H)-酮 |
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分类
- {SA} Asymmetric Synthesis, Chemical Synthesis, Chiral Building Blocks, Heterocyclic Building Blocks, Others
- Asymmetric Synthesis, Chemical Synthesis, Chiral Building Blocks, Heterocyclic Building Blocks, Others
- {SNA} Asymmetric Synthesis, Chemical Synthesis, Chiral Building Blocks, Heterocyclic Building Blocks, Other Heterocyclic Building Blocks
产品应用
- Precursor in the biosynthesis of Biopterin. First isolated from the pupae of bees.
相关文献及参考
- 1. D. Fuchs et al. Int. Arch. Allergy Immunol. 101 , 1, (1993) 摘要
- Beil. 26 ,IV,4038
- Fukushima, S., et al.: J. Biol. Chem., 247, 4549 (1972),
- Kobashi, I., et al.: Agric. Biol. Chem., 35, 47 (1971),
- Merck 14 ,6462
- [1]. Murr C, et al. Neopterin as a Marker for Immune System Activation. Current Drug Metabolism [01 Apr 2002, 3(2):175-187].
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
其他信息
- (+)-Neopterin is a precursor of tetrahydrobiopterin and can be used as a biochemical marker indicative of cell proliferation. Elevated levels of (+)-neopterin are correlated to immune system activation, malignant disease, allograft rejection, and viral infections. Additionally, (+)-neopterin serves as a cofactor for pterin in biological systems.
