CAS 133-06-2 MFCD00041811-2-((Trichloromethyl)thio)-3a,4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione 克菌丹 TAO{mole}

2-((Trichloromethyl)thio)-3a,4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione 克菌丹

CAS 133-06-2 MFCD00041811

化学结构图

SMILES: O=C1C2CC=CCC2C(=O)N1SC(Cl)(Cl)Cl

化学属性

Mol. Formula	C₉H₈Cl₃NO₂S
Mol. Weight	300.59
Melting Point	>167ºC (dec.)
Density	0.791
Flash Point	2 °C
Solubility	不溶于水，溶于氯仿、苯、乙醚等。
Boiling Point

别名和识别编码

Chemical Name	2-((Trichloromethyl)thio)-3a,4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione
CAS Number	133-06-2
Synonym	######## 1,2,3,6-Tetrahydro-N-(trichloromethylthio)phthalimide 1,2,3,6-四氢-N-(三氯甲硫基)邻苯二酰亚胺 1H-Isoindole-1,3(2H)-dione, 3a,4,7,7a-tetrahydro-2-[(trichloromethyl)thio]- 1H-isoindole-1,3(2H)-dione, 3a,4,7,7a-tetrahydro-2-[(trichloromethyl)thio]- 1h-isoindole-1,3-(2h)-dione,3a,4,7,7a-tetrahydro-2-((trichloromethyl)thio)-[q 2-Trichloromethylsulfanyl-3a,4,7,7a-tetrahydro-isoindole-1,3-dione 2-[(Trich 2-[(Trichlo 3a,4,7,7a-tetrahydro-2-((trichloromethyl)thio)-1H-isoindole-1,3(2H)-dione 3a,4,7,7a-tetrahydro-2-[(trichloromethyl)thio]-1H-isoindole-1,3(2H)-dione 4-cyclohexene-1,2-dicarboximide, N-[(trichloromethyl)thio]- Aacaptan Captab Captan {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {}
MDL Number	MFCD00041811
PubChem Substance ID	24868836
Beilstein Registry Number	0023177
EC Number	205-087-0
Chemical Name Translation	克菌丹
Merck Number	1772
Wiswesser Line Notation	T56 BVNV GUTJ CSXGGG

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品牌质保精细包装现货库存一流品牌服务

产品应用

克菌丹是有机杀菌剂的一个重要品种，对三麦、水稻、玉米、棉花、蔬菜、果树、瓜类、烟草等作物多种病害均有良好的防治效果。对三麦赤霉病防治效果仅次于多菌灵，对水稻纹枯病、稻瘟病、小麦秆绣病、烟草赤星病、棉花苗期病害、苹果腐烂病等也具有良好的防治效果。该品还用于拌种防治棉花苗期病害

安全信息

RTECSGW5075000

GHS Symbol

Precautionary statements

P273 Avoid release to the environment. 避免释放到环境中。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P304+P340+P312
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P305+P351+P338+P310
P403+P233
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
P305+P351+P338
P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。

Hazard statements

H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
H351 Suspected of causing cancer 怀疑致癌
H317 May cause an allergic skin reaction 可能导致皮肤过敏
H318 Causes serious eye damage 严重伤害眼睛
H331 Toxic if inhaled 吸入中毒
H332 Harmful if inhaled 吸入有害
H319 Causes serious eye irritation 严重刺激眼睛
H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
H312 Harmful in contact with skin 皮肤接触有害
H302 Harmful if swallowed 吞食有害

Hazard Codes T,N F,Xn T;N T;N,N,T,Xn,F

WGK Germany2

Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Signal word Danger

Safety Statements

S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S29 Do not empty into drains 不要排入下水道；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；

Risk Statements

R50 Very toxic to aquatic organisms 对水生生物极毒
R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
R23 Toxic by inhalation 吸入有毒
R11 Highly flammable 非常易燃
R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
R36 Irritating to eyes 刺激眼睛

UN Number 3077/9099 UN 3077/9099

Storage condition -20 0-6°C

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1075 gm/kg/80W-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-15,1977

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 540 gm/kg/80W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-15,1977

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4500 mg/m3/2H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   45,320,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2650 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 38(10),24,1973

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 9 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FMCHA2 Farm Chemicals Handbook.  (Meister Pub., 37841 Euclid Ave.,
   Willoughy, OH 44094)  Volume(issue)/page/year: -,C59,1991

TYPE OF TEST            : LDLo - Lowest published lethal dose
RO

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 7 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   45,320,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       :

TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 2100 nmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 182,193,1987

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 310 ng/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 130,79,1984

TYPE OF TEST            : Mutation in microorganisms
T

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 5 ug/plate
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB268-647

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 5 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 131,101,1984

TYPE OF TEST            : Gene conversion and mitotic recombination
TEST SYSTEM             : Mold - Aspergillus nidulans
DOSE/DURATION           : 2 mg/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 46,395,1977

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 950 pmol/L
REFERENCE :
   CNJGA8 Canadian Journal of Genet

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 105 mg/kg
SEX/DURATION            : female 10-16 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Newborn - sex ratio
REFERENCE :
   SAKNAH Soobshcheniia Akademii Nauk Gruzinskoi SSR.  (V/O Mezhdunarodnaya
   Kniga, 113095 Mo

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2500 mg/kg
SEX/DURATION            : female 6-10 day(s) after co

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 3750 mg/kg
SEX/DURATION            : female 1-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fert

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 900 mg/kg
SEX/DURATION            : female 9-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
   (e.g., placenta, umbilical cord)
   Reproductive - Specific Developmental Abnormalities - eye/ear
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB223-160

其他信息

Sigma Aldrich:133-06-2(sigmaaldrich)
急救治疗:误食者立即催吐、洗胃、导泻对症治疗忌油类食物，禁酒。
毒性分级:低毒
中毒
灭火剂:干粉、泡沫、砂土
外观性质:无色晶体，工业品为淡黄色粉末。
用途四:克菌丹是有机杀菌剂的一个重要品种，对三麦、水稻、玉米
上游原料:马来酸酐 --> 1,3-丁二烯 --> 邻苯二甲酰亚胺 --> 马来酸 --> 四氢苯酐 --> 四氢化邻苯二甲酸酐 --> 1,2,3,6-四氢邻苯二甲酰亚胺
用
溶于氯仿、苯、乙醚，不溶于水，对酸稳定
方法二:由丁二烯与顺丁烯二酸酐反应生成1,2,3,6-四氢苯二甲酸酐，再与氨作用合成1,2,3,6-四氢苯二甲酰亚胺，最后与三氯硫氯甲烷反应得到克菌丹。
毒性:大鼠急性经口LD 50 为9000mg/kg，对皮肤及黏膜有刺激作用。每日用300mg/kg剂量的工业品喂狗66周未出现慢性中毒症状，对大鼠2年饲喂试验的无作用剂量为1000mg/kg。动物试验发现致畸、致突变作用。
急性毒性:口服- 大鼠 LD50: 9000 毫克/ 公斤; 口服- 小鼠 LD50: 7000 毫克/ 公斤
用途一:用作保护性杀菌剂，叶面喷施或拌种均可
MSDS 信息:灭菌丹(133-06-2).msds
储运特性:库房通风低温干燥; 与食品原料分开储运
类别:农药
下游产品:3-十五烷基苯酚
用途四:克菌丹是有机杀菌剂的一个重要品种，对三麦、水稻、玉米、棉花、
MOL 文件:133-06-2.mol
用途三:克菌丹是有机杀菌剂的一个重要品种，对三麦、水稻、玉米、棉花、蔬菜、果树、瓜类、烟草等作物多种病害均有良好的防治效果。对三麦赤霉病防治效果仅次于多菌灵，对水稻纹枯病、稻瘟病、小麦秆绣病、烟草赤星病、棉花苗期病害、苹果腐烂病等也具有良好的防治效果。该品还用于拌种防治棉花苗期病害。大鼠口服LD50为9000mg/kg。对皮肤皮粘膜有刺激作用。
职业标准:TWA 5 毫克/ 立方米; STEL 15 毫克/ 立方米
用途二:三氯甲硫基类广谱的保护性杀菌剂，对大麦、小麦、燕麦、水稻、玉米、棉花、蔬菜、果树、瓜类、烟草等作物的许多病害均有良好的防治效果。对作物安全，无药害，而且还具有刺激植物生长的作用。对水稻纹枯病、稻瘟病、小麦秆锈病，烟叶赤星病，棉花苗期病，苹果腐烂病等也有良好的防治效果。
{Chemicalboo
TCI Shanghai:克菌丹 Captan,>;98.0%(T)(133-06-2)
方法一:1，2，，3，4-四氢化邻苯二甲酐的制备将顺丁烯二酸杆和苯混合加热，使顺酐溶解，待温度升至70℃时，通入丁二烯，在（75±2）℃反应，直至通气反应至终点，然后趁热把物料放入结晶槽，冷却至室温，过滤，滤饼于50～70℃干燥，得1，2，3，4-四氢化邻苯二甲酸酐，含量95%以上。 1，2，3，4-四氢化邻苯二甲酰亚胺的制备将氨水加长反应瓶中，于50℃以下加长1，2，3，4-四氢化邻苯二甲酸酐，逐渐升温至105～110℃，使剩余的游离氨及水蒸发，再逐渐升温至230～250℃，约5～6h，将物料放出，冷却至80℃,加热水溶解，冷却结晶，过滤，干燥，得1，2，3，4-四氢化邻苯二甲酰亚胺。克菌丹的合成将1，2，3，4-四氢化邻苯二甲酸亚胺加入到预冷至0℃的5%～6%的氢氧化钠溶液中，待完全溶解后，加入三氯硫氯甲烷，在0～5℃反应。当pH值为8以下时，视反应结束，过滤，滤饼用水洗至中性，干燥，得克菌丹。
图谱信息:克菌丹(133-06-2)红外图谱(IR2) 克菌丹(133-06-2)核磁图( 1 HNMR) 克菌丹(133-06-2)红外图谱(IR1) 克菌丹(133-06-2)质
溶于氯仿、苯、乙醚，不溶于水，对酸稳定，在强碱作用下分解