CAS 92-87-5 MFCD00039765-Benzidine 联苯胺 TAO{mole}

Benzidine 联苯胺

CAS 92-87-5 MFCD00039765

化学结构图

SMILES: Nc1ccc(-c2ccc(N)cc2)cc1

化学属性

Mol. Formula	C₁₂H₁₂N₂
Mol. Weight	184.24
Melting Point	127-128°C
Boiling Point
Density	1.25
Solubility	Soluble in water (0.32 mg/ml at 25 °C), DMSO, methanol, alcohol, and ether.
Stability	对光线敏感
Flash Point	-

别名和识别编码

Chemical Name	Benzidine
CAS Number	92-87-5
Alfabeta Name	BIPHENYLDIAMINE 1144---,,''
MDL Number	-
Synonym	(1,1'-Biphenyl)-4,4'-diamine (1,1'-Biphenyl)-4,4'-diamine 1,1'-biphenyl-4,4'-diamine 4'-Amino-[1,1'-biphenyl]-4-ylamine 4,4'-Bianiline 4,4'-Biphenylenediamine 4,4'-Diamino-1,1'-biphenyl 4,4'-Diaminobiphenyl 4,4'-Diaminodiphenyl 4,4'-Diphenylenediamine 4,4'-biphenyldiamine 4,4'-Bianiline 4,4'-Biphenyldiamine 4,4'-Biphenylenediamine 4,4'-Diamino-1,1'-biphenyl 4,4'-Diaminobiphenyl 4,4'-Diaminodiphenyl 4,4'-Diphenylenediamine 4-(4-Aminophenyl)aniline p,p'-Bianiline p,p'-Diaminobiphenyl p-diaminodiphenyl Benzidin Benzidina Benzidine Benzidine, 9 Benzidine, 95%
PubChem Substance ID	24869744
EC Number	202-199-1
Beilstein Registry Number	0742770
Chemical Name Translation	联苯胺
InChIKey	HFACYLZERDEVSX-UHFFFAOYSA-N
Wiswesser Line Notation	ZR DR DZ
LabNetwork Molecule ID	LN00140954
Canonical SMILES	-

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产品应用

比色法测定各种氧化剂(CN-, NO2-, ClO3-, SO42-)，氧化性金属、过氧化物酶、氰化物和血液的检定。硫酸盐、钨酸盐、磷酸盐和糖分的测定。氧化还原指示剂。用于偶氮染料中间体，也作不溶偶氮染料的显色剂。
标准溶液用于ICP-AES、AAS、AFS、ICP-MS、离子色谱等。滴定分析用标准溶液。
联苯胺（4,4′-二氨基联苯）是一种环境的药物毒素，具有增加癌症的风险。联苯胺，可以使用作为标准物质。联苯胺可用于其遗传毒性机制的研究。

安全信息

Warnings IRRITANT 危化品目录(2015) 危险化学品

Hazard statements

H350 May cause cancer 可能致癌
H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
H302 Harmful if swallowed 吞食有害

GHS Symbol

Precautionary statements

P501 Dispose of contents/container to..… 处理内容物/容器.....
P308+P313
P273 Avoid release to the environment. 避免释放到环境中。
P201 Obtain special instructions before use. 使用前获取专门指示。

WGK Germany3

Signal word Danger

Hazard Codes F,T T;N T,N

Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

RTECSDC9625000

Safety Statements

S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；

Risk Statements

R45 May cause cancer 可能致癌
R22 Harmful if swallowed 吞咽有害
R50/53

UN Number 1885

Storage condition -20 -20°C, Hygroscopic 密封保存。密封避光保存。

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 25560 ng/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
REFERENCE :
   EKSODD Eksperimental'naya Onkologiya.  Experimental Oncology.  (V/O
   Mezhdunarodnaya Kniga, 113095 Mosow, USSR)  V.1-    1979-
   Volume(issue)/page/year: 9(4),73,1987

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1200 mg/kg/26W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   VOONAW Voprosy Onkologii.  Problems of Oncology.  For English translation,
   see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-10,
   1928-37; V.1-    1955-  Volume(issue)/page/year: 10(5),50,1964

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intratracheal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 315 mg/kg/34W
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
   Skin and Appendages - tumors
REFERENCE :
   BEXBAN Bulletin of Experimental Biology and Medicine (English Translation).
   Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY
   10013)  V.41-    1956-  Volume(issue)/page/year: 69,68,1970

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1620 gm/kg/45W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
REFERENCE :
   AICCA6 Acta Unio Internationalis Contra Cancrum.  (Louvain, Belgium) V.1-20,
   1936-64.  F

TYPE OF TEST            : LD50 - Lethal dose, 50 percent k

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie.  (Leipzig,
   Ger. Dem. Rep.)  V.1-109, 1873-1925.  For publisher information, see NSAPCC.
    Volume(issue)/page/year: 58,167,1907

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 214 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB214-270

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie.  (Leipzig,
   Ger. Dem. Rep.)  V.1-109, 1873-1925.  For publisher information, see NSAPCC.
    Volume(issue)/page/year: 58,167,1907

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 309 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB214-270

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 1 mg/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 54,101,1978

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 400 ng/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Kidney
DOSE/DURATION           : 80 ug/L
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   37,873,1978

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 3 mmol/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 7,267,1985

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 160 ug/L
REFERENCE :
   PMRSDJ Progress in Mutation Research.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1981- Volume(issue)/page/year:
   1,528,1981

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 567 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 192,239,1987

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Mammal - dog Cells

其他信息

不溶于冷水，溶于热水，易溶于乙醇、乙醚。露置空气中或光线影响下颜色变深。1g溶于5ml沸乙醇、50ml乙醚、107ml沸水、2500ml冷水。其蒸气易被皮肤吸收。中等毒，半数致死量(大鼠，经口)309mg/kg。有致癌可能性。