L-(-)-Carnitine 左旋肉碱

CAS 541-15-1 MFCD00038747

化学结构图

541-15-1
SMILES: C[N+](C)(C)CC(O)CC(=O)[O-]

化学属性

Mol. FormulaC7H15NO3
Mol. Weight161.20
Melting Point208-212°C
TSCANo

别名和识别编码

Chemical NameL-(-)-Carnitine
MDL NumberMFCD00038747
Synonym (-)-Carnitine (R)-(-)-3-Hydroxy-4-(trimethylammonio)butyrate (R)-3-Hydroxy-4-(trimethylammonio)butyrate, Vitamin BT (R)-Carnitine 3-Carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium hydroxide, inner salt Carnitine L-Carnitine {} {ALD} L-肉碱
EC Number208-768-0
CAS Number541-15-1
Merck Number1849
Beilstein Registry Number4292315
PubChem Substance ID10917
Chemical Name Translation左旋肉碱
Reaxys-RN4292315
InChIKeyPHIQHXFUZVPYII-ZCFIWIBFSA-N
Wiswesser Line NotationOV1YQ1K1&1&1
LabNetwork Molecule IDLN00195276
InChIInChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1
Canonical SMILESC[N+](C)(C)C[C@H](O)CC([O-])=O
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分类

  • {SNA} Analytical Standards, Chromatography, Pharmaceutical Standards, Pharmacopeia Standards, USP Standards, USP Standards L - M, 分析/色谱
  • {SNA} Analytical Standards,
  • {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, EP Standards, EP Standards L - M, Pharmaceutical Standards, Pharmacopeia Standards
  • {SNA} Other Biochemical, Phytochemicals by Chemical Classification, 细胞生物学, 营养研究
  • {SNA} Cell Biology, Nutrition Research, Other Biochemical, Phytochemicals by Chemical Classification
  • {SNA} Nutrition Research, Other Biochemical, Phytochemicals by Chemical Classification, 细胞生物学

产品应用

  • 可以促进线粒体的脂肪酸氧化作用并且达到其他生化功能，这些功能包括乙酰缓冲能及在无氧产能情况下维持足够辅酶A在线粒体内之浓度，刺激三羧酸的循环和在肌肉持久运动下刺激ATP从线粒体向外输出。用于动物健康生长。

相关文献及参考

  • [2]. Miyagawa T, et al. Effects of oral L-carnitine administration in narcolepsy patients: a randomized, double-blind, cross-over and placebo-controlled trial. PLoS One. 2013;8(1):e53707.
  • [3]. Abd Eldaim MA, et al. l-Carnitine-induced amelioration of HFD-induced hepatic dysfunction is accompanied by a reduction in hepatic TNF-α and TGF-β1. Biochem Cell Biol. 2018;96(6):713-725.
  • Merck:14,1849
  • Merck:14,1849 Beilstein:4(3)3185
  • [1]. Ferreira GC, et al. L-Carnitine and Acetyl-L-carnitine Roles and Neuroprotection in Developing Brain. Neurochem Res. 2017;42(6):1661-1675.
  • [1]. Ferreira GC, et al. L-Carnitine and Acetyl-L-carnitine Roles and Neuroprotection in Developing Brain. Neurochem Res. 2017;42(6):1661-1675.
  • [2]. Miyagawa T, et al. Effects of oral L-carnitine administration in narcolepsy patients: a randomized, double-blind, cross-over and placebo-controlled trial. PLoS One. 2013;8(1):e53707.
  • [3]. Abd Eldaim MA, et al. l-C

安全信息

RTECSBP2980000
WGK Germany3
GHS Symbol
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Signal word
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Hazard Codes Xi
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition 2-8°C, stored under nitrogen 室温保存 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 9 gm/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Behavioral - convulsions or effect on seizure threshold
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   ABMGAJ Acta Biologica et Medica Germanica.  (Berlin, Ger. Dem. Rep.) V.1-41,
   1958-82.  For publisher information, see BBIADT. Volume(issue)/page/year:
   35,645,1976

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 7 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CTRRDO Cancer Treatment Reports.  (Washington, DC)  V.60-71, 1976-87.  For
   publisher information,  see JNCIEQ.  Volume(issue)/page/year: 63,558,1979

其他信息

  • 水中溶解度:2500 g/L (20°C)；不溶于丙酮、乙醚、苯；溶于热乙醇。
  • 不溶于丙酮、乙醚、苯；溶于热乙醇。

系列性分类

  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Phytochemicals by Chemical Classification - Nutrition Research
  4. Other Biochemical - Phytochemicals by Chemical Classification
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Amine Salts - Nitrogen Compounds
  1. Life Science 生命科学
  2. Metabolomics 代谢组学
  3. Metabolic Pathways - Metabolomics
  4. Metabolites and Cofactors on the Metabolic Pathways Chart - Metabolic Pathways
  5. Amino Acid - Metabolites and Cofactors on the Metabolic Pathways Chart
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Quaternary Ammonium Compounds 季铵化合物
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Biochemicals Found in Plants
  4. Lipids
  5. Polyunsaturated
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Metabolomics
  4. Metabolic Pathways
  5. Metabolites and Cofactors on the Metabolic Pathways Chart
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Metabolomics
  5. Metabolic Pathways
  6. Metabolites and Cofactors on the Metabolic Pathways Chart
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Nutrition Research
  4. Biochemicals Found in Plants
  5. Lipids
  6. Polyunsaturated
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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