CAS 125-33-7 MFCD00038662-Primidone,Primidone 扑米酮 TAO{mole}

Primidone,Primidone 扑米酮

CAS 125-33-7 MFCD00038662

化学结构图

SMILES: CCC1(c2ccccc2)C(=O)NCNC1=O

化学属性

Mol. Formula	C12H14N2O2
Mol. Weight	218
Melting Point	281 °C
Solubility	Soluble in acetic acid (50 mg/ml), DMSO (100 mM), methanol, ethanol (3 mg/ml at 25 °C), and water (<1 mg/ml at 25 °C).
Appearance	白色结晶性粉末。熔点281-282℃。微溶于醇，几乎不溶于水、丙酮或苯。无臭，味微苦。

别名和识别编码

Chemical Name	Primidone,Primidone
CAS Number	125-33-7
Synonym	2-Desoxyphenobarbital, 5-Ethyl-5-phenylhexahydropyrimidine-4,6-dione 去氧苯巴比妥 5-Aethyl-5-phenyl-hexahydropyrimidin-4,6-dion 5-乙基-5-苯基-二氢-4,6(1H,5H)-嘧啶二酮 NCI-C56360 5-Phenyl-5-aethylhexahydropyrimidindion-(4,6) hexamidine(theantispasmodic) 5-ETHYLDIHYDRO-5-PHENYL-4,6(1H,5H)-PYRIMIDINEDIONE 5-phenyl-5-ethyl-hexahydropyrimidine-4,6-dione Primidon Cyral Desoxyphenobarbitone Mysedon 5h)-pyrimidinedione,5-ethyldihydro-5-phenyl-6(1h Primaclone 2-Desoxyphenobarbital 5-Ethylhexahydro-4,6-dioxo-5-phenylphrimidine ROE 101 Primakton 扑米酮甲醇溶液 Majsolin Primacione Hexamidine Pyrimidone medi-pets 2-脱氧苯巴比妥 5-乙基-5-苯基六氢嘧啶-4,6-二酮 2-Deoxyphenobarbital Lepimidin 5-Ethyldihydro-5-phenyl-4,6(1H,5H)-pyrimidinedione 美速林 Mizodin Milepsin Prysoline Mylepsin Mizolin Primidone Mysoline Sertan
MDL Number	MFCD00038662
PubChem Substance ID	125307742
EC Number	204-737-0
Reaxys-RN	218034
Beilstein Registry Number	24(5)102
Merck Number	7746
Chemical Name Translation	扑米酮
Wiswesser Line Notation	T6MV DVMTJ C2 CR
LabNetwork Molecule ID	LN00196100
InChI	InChI=1S/C12H14N2O2/c1-2-12(9-6-4-3-5-7-9)10(15)13-8-14-11(12)16/h3-7H,2,8H2,1H3,(H,13,15)(H,14,16)

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产品应用

A compound that potentiates GABA receptor function.

安全信息

RTECSUV9100000

GHS Symbol

Precautionary statements

P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P201 Obtain special instructions before use. 使用前获取专门指示。
P501 Dispose of contents/container to..… 处理内容物/容器.....
P405 Store locked up. 上锁保管。
P301+P312+P330
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P308+P313

Hazard statements

H302 Harmful if swallowed 吞食有害
H351 Suspected of causing cancer 怀疑致癌

WGK Germany3

Signal word

Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

Hazard Codes Xn

Safety Statements

Risk Statements

Packing GroupIII

Hazard Class6.1(b)

UN Number 3249

Storage condition 储存温度-20°C 储存温度 2-8°C

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 280 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   34,271,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 8,230,1953

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 332 mg/kg
TOXIC EFFECTS :
   Behavioral - anticonvulsant
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 15,403,1981

TYPE OF

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 340 mg/kg
TOXIC EFFECTS :
   Behavioral - anticonvulsant
REFERENCE :
   RPTOAN Russian Pharmacology and Toxicology (English Translation).
   Translation of FATOAO.  (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
   UK)  V.30-    1967-  Volume(issue)/page/year: 43,73,1980

TYPE OF TEST            : Micronucleus test
TEST SYSTEM             : Rodent - hamster Embryo
DOSE/DURATION           : 250 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 392,61,1997

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 375 mg/L
REFERENCE :
   AGMGAK Acta Geneticae Medicae et Gemellologiae.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.1-    1952-  Volume(issue)/page/year:
   21,305,1972

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 6666 ug/plate
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 8(Suppl
   7),1,1986

TYPE OF TEST            : Sperm Morphology
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 875 mg/kg
REFERENCE :
   TOLED5 Toxicology Letters.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1977-  Volume(issue)/page/year: 34,149,1986

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Leukocyte
DOSE/DURATION           : 1 mg/L
REFERENCE :
   AJOGAH American Journal of Obstetrics and Gynecology.  (C.V. Mosby Co.,
   11830 Westline Industrial Dr., St. Louis, MO 63146)  V.1-    1920-
   Volume(issue)/page/year: 116,867,1973

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 2025 mg/kg
SEX/DURATION            : female 1-39 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - cardiovascular
   (circulatory) system
   Reproductive - Effects on Newborn - Apgar score (human only)
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th S

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 10350 mg/kg
SEX/DURATION            : female 1-39 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - skin and skin
   appendages
   Reproductive - Specific Developmental Abnormalities - cardiovascular
   (circulatory) system
REFERENCE :
   JOPDAB Journal of Pediatrics.  (C.V. Mosby Co., 11830 Westline Industrial
   Dr., St. Louis, MO 63141) V.1-    1932-  Volume(issue)/page/year:
   94,835,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 10350 mg/kg
SEX/DURATION            : female 1-39 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - other neonatal measures or effects
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   JOPDAB Journal of Pediatrics.  (C.V. Mosby Co., 11830 Westline Industrial
   Dr., St. Louis, MO 63141) V.1-    1932-  Volume(issue)/page/year:
   94,835,1979

其他信息

MOL 文件:125-33-7.mol
Sigma Aldrich:125-33-7(sigmaaldrich)
MSDS 信息:Primidone(125-33-7).msds
上游原料:苯基乙基丙二酸二乙酯
普里米酮
Primidone 是一种嘧啶二酮类抗惊厥药。
用途一:用于癫痫大发作和精神运动性发作。抗癫痫作用与苯巴比妥近似，但比苯巴比妥有选择性；作用强度不如苯妥英钠，但两者合用有协效应。
图谱信息:扑米酮(125-33-7)红外图谱(IR2) 扑米酮(125-33-7)红外图谱(IR1)
方法一:将乙酸乙酯加入乙醇钠中，回流半小时，冷却至室温，加入乙基苯基丙二酸二乙酯及硫脲，加流9h。冷至0℃，加入乙醇，在0-5℃滴入盐酸至pH=3-3.5。加入锌粉，升温至回流，缓缓补加盐酸，保持的应液有2-3%含酸量，加毕，保温3h。趁热过滤，滤液回收乙醇。冷至20℃，加水，过滤，洗涤滤饼，得扑米酮。