1-(Diphenylmethyl)Piperazine 1-(二苯基甲基)哌嗪
CAS 841-77-0 MFCD00038379
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信息真实价格透明
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专业采购外包团队在线服务
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分类
- Pharmaceuticals
- {SNA} Building Blocks, C16 to C29, Chemical Synthesis, Heterocyclic Building Blocks, Piperazines
- Aromatics
- Heterocycles
- Intermediates & Fine Chemicals,
产品应用
- Cinnarizine (C465300) impurity.
相关文献及参考
- Zhang, H., et al.: Biochemistry, 43, 8290 (2004),
安全信息
GHS Symbol
- S22 Do not breathe dust 不要吸入粉尘;
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R22 Harmful if swallowed 吞咽有害
- R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P312
- P301+P312+P330
- P302+P350
- P302+P352
- P302+P352+P332+P313+P362+P364
- P304+P312
- P304+P340
- P305+P351+P338
- P305+P351+P338+P337+P313
- P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
- P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
- P330 Rinse mouth. 漱口
- P332+P313
- P337+P313
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
- P403+P233
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H302 Harmful if swallowed 吞食有害
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H332 Harmful if inhaled 吸入有害
- H335 May cause respiratory irritation 可能导致呼吸道刺激
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 500 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement REFERENCE : TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (2),28,1997
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 38 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year: 31,453,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement REFERENCE : TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (2),28,1997
其他信息
- F:34
- Sigma Aldrich:841-77-0(sigmaaldrich)
- Alfa Aesar:1-二苯甲基哌嗪,97% 1-Benzhydrylpiperazine, 97%(841-77-0)
- 上游原料:哌嗪 --> 稀盐酸 --> 二苯甲醇 --> 二苯氯甲烷
- 敏感性:Air Sensitive
- MOL 文件:841-77-0.mol
- 下游产品:桂利嗪 --> 奥沙米特 --> 美克洛嗪
- Hazard Note:Irritant
- Acros Organics:1-二苯甲基哌嗪 1-(Diphenylmethyl)piperazine, 97%(841-77-0)
- 用途一:H1-受体拮抗剂奥沙米特(Oxatomide)的中间体。
- MSDS 信息:Benzhydrylpiperazine(841-77-0).msds
- 检测方法:NMR
- 二苯甲基哌嗪价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 122931000 二苯甲基哌嗪 1-(Diphenylmethyl)piperazine 97% 100 GR 1110元 2010/06/21 122935000 二苯甲基哌嗪 1-(Diphenylmethyl)piperazine 97% 500 GR 4380元 2010/05/25 L11530 1-二苯甲基哌嗪,97% 1-Benzhydrylpiperazine, 97% 25g 269元
- 方法一:将二苯甲醇9.2克加至浓盐酸53毫升中,搅拌回流1小时,冷却。用乙醚提取,无水硫酸钠干燥2小时,蒸出乙醚,残液转入滴液漏斗中备用。将无水哌嗪12.8克加至甲苯40毫升中,加热至80℃。滴加上述二苯氯甲烷,滴毕,保持80-90℃反应3小时,甲苯层用稀盐酸提取3次,提取液用氢氧化钠碱化,得淡黄色固体7.7克,收率61%,进一步提纯可用乙醇重结晶。
- 存储注意事项:空气敏感