CAS 603-50-9 MFCD00038039-Bisacodyl, 98% 4,4’-(2-吡啶亚甲基)双酚二乙酸酯 TAO{mole}

Bisacodyl, 98% 4,4’-(2-吡啶亚甲基)双酚二乙酸酯

CAS 603-50-9 MFCD00038039

化学结构图

SMILES: CC(=O)Oc1ccc(C(c2ccc(OC(C)=O)cc2)c2ccccn2)cc1

化学属性

Mol. Formula	C22H19NO4
Mol. Weight	361
TSCA	Yes
Melting Point	132.0 to 136.0 deg-C
Solubility	DMSO 72 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

别名和识别编码

Chemical Name	Bisacodyl, 98%
CAS Number	603-50-9
Synonym	(4,4'-Diacetoxydiphenyl)(2-pyridyl)methane 2-(4,4'-Diacetoxydiphenylmethyl)pyridine 4,4'-(2-pyridylmethyl 4,4'-(2-pyridylmethylene)bisphenol diacetate 4,4'-(2-Pyridinylmethylene)bisphenol 4,4'-(2-pyridylmethylene)bisphenol diacetate 4,4'-(2-吡啶亚甲基)双酚二乙酸酯 4,4'-(2-吡啶甲 4,4'-DIACETOXYDIPHENYLPYRIDYL-2-METHANE 4,4'-Diacetoxydiphenylpyrid-2-ylmethane Agaroletten Apo Bisacodyl Apo-Bisacodyl Bekunis Bisacodyl Bicol Bis(p-acetoxyphenyl)-2-pyridylmethan Bisac Evac Bisac-Evac Bisacodyl Bisacodyl Tannex Bisacodyl Uniserts Bisacodyl, Bekunis Bisacodyl, Fleet Bisalax Bisco Lax Bisco Zitron Bisco-Lax Bisco-Zitron Broxalax
MDL Number	MFCD00038039
PubChem Substance ID	354334116
EC Number	210-044-4
Merck Number	1242
Chemical Name Translation	4,4’-(2-吡啶亚甲基)双酚二乙酸酯
Wiswesser Line Notation	T6NJ BYR DOV1&R DOV1
Beilstein Registry Number	0323727
LabNetwork Molecule ID	LN01277896
Reaxys-RN	323727
InChI	InChI=1S/C22H19NO4/c1-15(24)26-19-10-6-17(7-11-19)22(21-5-3-4-14-23-21)18-8-12-20(13-9-18)27-16(2)25/h3-14,22H,1-2H3

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产品应用

Cathartic.

安全信息

RTECSSM8750000

GHS Symbol

Precautionary statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P301+P312
P302+P352
P302+P352+P332+P313+P362+P364
P304+P340
P305+P351+P338
P305+P351+P338+P337+P313
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P330 Rinse mouth. 漱口
P332+P313
P337+P313
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P403+P233
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H302 Harmful if swallowed 吞食有害
H303 May be harmfully swallowed 吞食可能有害
H315 Causes skin irritation 会刺激皮肤
H319 Causes serious eye irritation 严重刺激眼睛
H335 May cause respiratory irritation 可能导致呼吸道刺激

WGK Germany3

Signal word Warning

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes Xi

Safety Statements

S36 Wear suitable protective clothing 穿戴适当的防护服；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R22 Harmful if swallowed 吞咽有害

Storage condition 储存温度-20°C 2-8°C

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : In

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >15 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,854,1990

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 3,19,1953

TYPE OF TEST            : LD50 - L

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 17500 mg/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - respiratory stimulation
   Blood - hemorrhage
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   2,243,1960

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 3,19,1953

其他信息

Sigma Aldrich:603-50-9(sigmaaldrich)
上游原料:苯酚 --> 2-甲基吡啶
MOL 文件:603-50-9.mol
比沙可啶
用途一:是安全有效的缓泻药物，用于治疗便秘
MSDS 信息:[4-[(4-Acetyloxyphenyl)-pyridin-2-ylmethyl]phenyl] acetate(603-50-9).msds