CAS 50-22-6 MFCD00037715-Corticosterone 皮质甾酮 TAO{mole}

Corticosterone 皮质甾酮

CAS 50-22-6 MFCD00037715

化学结构图

SMILES: C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2C(=O)CO

化学属性

Mol. Formula	C21H30O4
Mol. Weight	346
Melting Point	180-183
Density	1.21
Solubility	Soluble in acetone, methanol, ethanol (10 mM), chloroform, and DMSO (100 mM). Insoluble in water.

别名和识别编码

Chemical Name	Corticosterone
CAS Number	50-22-6
Synonym	Corticosteron 皮质酮 11ß,21-dihydroxypregn-4-ene-3,20-dione 11ß,21-dihydroxy-pregn-4-ene-3,20-d 11β 11ß, 21-Dihydroxyprogesterone Reichstein's substance H 肾上腺酮,可的松,皮质酮,11β,21-二羟基-孕烯-3,20-酮, 11β,21-二羟基孕酮 11β,21-二羟基-孕烯-3 4-PREGNEN-11B,21 11BETA,21-DIHYDROXY-PROGESTERONE (11?)-11,21-Dihydroxy-pregn-4-ene-3,20-dione 11ß,21-Dihydroxypregn-3,20-dione 11β, 21-Dihydroxyprogesterone KENDALL'S COMPOUND ''B'' NS (11-beta)-11,21-Dihydroxypregn-4-ene-3,20-dione Pregn-4-ene-3,20-dione, 11,21-dihydroxy-, (11-beta)- 17-Deoxycortisol CORTICOSTERONE {uni_ha 可的松 11-Hydroxycorticoaldosterone 11β,2 肾上腺酮,可的松,11β,21-二羟基-孕烯-3,20-酮, 11β,21-二羟基孕酮, 皮质酮 Pregn-4-ene-3,20-dione, 11,21-dihydroxy-, (11ß)- 4-PREGNENE-11BETA,21-DIOL-3,20-DIONE 11BETA,21-DIHYDROXY-4-PRENENE-3,20-DIONE 11-beta,21-Dihydroxypregn-3,20-dione 4-Pregnene-11ß,21-diol-3,20-dione DELTA4-PREGNEN-11BETA, 21-DI 11,21-Dihydroxyprogesterone Kendall's compound B Kendall's compound B 11β,21-二羟基-孕烯-3,20-酮肾上腺酮 NSC-9705 Pregn-4-ene-3,20-dione, 11β, 21-dihydroxy- Preg RE 11ß,21-Dihydroxyprogesterone 11β,21-dihydroxy-pregn-4-ene-3,20-dione {Chemicalbook 皮质酮;肾上腺酮; NSC 9705 4-Pregnene-11-beta,21-diol-3,20-dione 11BETA,21-DIHYDROXYPREGN-4-ENE-3,20-DIONE 4-PREGNEN-11-BETA, 21-DIOL-3,20-DIONE 11,12-dihydroxyprogesterone 11-beta,21-Dihydroxyprogesterone 11β,21-Dihydroxypregn- 皮质
MDL Number	MFCD00037715
PubChem Substance ID	87565517
Beilstein Registry Number	2339601
EC Number	200-019-6
Reaxys-RN	2339601
Merck Number	2538
Chemical Name Translation	皮质甾酮
Wiswesser Line Notation	L E5 B666 OV MUTJ A1 CQ E1 FV1Q
LabNetwork Molecule ID	LN00195818

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产品应用

Corticosteroid is an activator of MCR.

安全信息

RTECSGM7650000

GHS Symbol

Precautionary statements

P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。

Hazard statements

H317 May cause an allergic skin reaction 可能导致皮肤过敏

Hazard Codes Xi

WGK Germany3

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Signal word Warning

Safety Statements

S36 Wear suitable protective clothing 穿戴适当的防护服；

Risk Statements

R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应

Storage condition 储存温度2-8℃

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - rat Cells - not otherwise specified
DOSE/DURATION           : 100 nmol/L
REFERENCE :
   ECREAL Experimental Cell Research.  (Academic Press, Inc., 1 E. First St.,
   Duluth, MN 55802) V.10-    1950-  Volume(issue)/page/year: 161,29,1985

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Bird - chicken Embryo
DOSE/DURATION           : 1500 pmol/L
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 257,804,1975

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Human Liver
DOSE/DURATION           : 2 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 370,49,1996

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 500 mg/kg
SEX/DURATION            : female 8-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   AGDJAI Journal of the Academy of General Dentistry.  (Academy of General
   Dentistry, 211 E. Chicago Ave., Suite 1200, Chicago, IL 60611)  V.1-
   1952(?)-  Volume(issue)/page/year: 18,34,1970

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1472 mg/kg
SEX/DURATION            : female 11-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 176,14,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 84 mg/kg
SEX/DURATION            : female 16-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   NRSCDN Neuroscience.  (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3
   OBW, UK)  V.1-    1976-  Volume(issue)/page/year: 66,467,1995

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 40 mg/kg
SEX/DURATION

其他信息

MOL 文件:50-22-6.mol
TCI Shanghai:皮质甾酮 Corticosterone,>;97.0%(LC)(50-22-6)
Sigma Aldrich:50-22-6(sigmaaldrich)
肾上腺酮价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 C0388 皮质甾酮 Corticosterone 5G 4930元 2014/06/02 C0388 皮质甾酮 Corticosterone 1G 1360元 2014/06/02 C0388 皮质甾酮 Corticosterone 100MG 273元
肾上腺酮价格(试剂级):更新日期产品编号产品名称包装价格 2011/04/16 C0388 皮质甾酮 Corticosterone 5G 4750元 2011/04/16 C0388 皮质甾酮 Corticosterone 1G 1310元 2011/04/16 C0388 皮质甾酮 Corticosterone 100MG 263元
图谱信息:肾上腺酮(50-22-6)红外图谱(IR1) 肾上腺酮(50-22-6)红外图谱(IR2) 肾上腺酮(50-22-6)质谱(MS)