CAS 52-21-1 MFCD00037710-Prednisolone Acetate 醋酸泼尼松龙 TAO{mole}

Prednisolone Acetate 醋酸泼尼松龙

CAS 52-21-1 MFCD00037710

化学结构图

SMILES: CC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C

化学属性

Mol. Formula	C23H30O6
Mol. Weight	402.53
Melting Point	240-244
Refractive index	112 ° (C=1, Dioxane)
Solubility	DMSO 81 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

别名和识别编码

Chemical Name	Prednisolone Acetate
CAS Number	52-21-1
Synonym	{Chemicalbook} 乙酸去氢皮质醇 21-(acetyloxy)-11,17-dihydroxy-4-diene-(11beta)-pregna-20-dione Prednisolone 21-acetate 1,4-PREGNADIEN-11-BETA, 17,21-TRIOL-3,20-DIONE 21-ACETATE Supercortyl 11,17-Dihydroxy-3,20-dioxopregna-1,4-dien-21-yl acetate 1,4-孕甾二烯-11β,17α,21-三醇-3,20-二酮 21-醋酸酯;11β,17α,21-三羟基-1,4-孕甾二烯-3,20-二酮 21-醋酸酯;21-乙酰氧基-1,4-孕甾二烯-11β,17α-二醇-3,20-二酮 ######## 乙酸强的松龙 1,4-PREGNADIENE-3,20-DIONE-11BETA,17ALPHA,21-TRIOL 21-ACETATE PREDNISOLONE 21-ACETATE 1,4-孕甾二烯-11β,17α,21-三醇-3,20-二酮 21-醋酸酯 11β,17α,21-三羟基-1,4-孕甾二烯-3,20-二酮 21-醋酸酯 21-乙酰氧基-1,4-孕甾二烯-11 醋酸去氢氢化可的松 Prednidoren 1,4-PREGNADIEN-11BETA,17ALPHA,21-TRIOL-3,20-DIONE 21-ACETATE Prediacortine {hazard_c (11beta)-21-(Acetyloxy)-11,17-dihydroxypregna-1,4-diene-3,20-dione INFLANEFRAN 21-(acetyloxy)-11,17-dihydroxy-4-diene-(11-beta)-pregna-20-dione 1-DEHYDROCORTISOL 21-ACETATE Prenema Cormalone 11b,17a,21-三 11b,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate PREDNISOLONE ACETATE 11beta,17,21-Trihydroxypregna-1,4-diene-3,20-dione 21-acetate 醋酸氢化泼尼松 Prednelan-N 11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE 21-ACETATE 17-Dol-3,20-dione 乙酸脱氢皮质醇 Meticortelone acetate
MDL Number	MFCD00037710
PubChem Substance ID	5834
Beilstein Registry Number	3111798
EC Number	200-134-1
Chemical Name Translation	醋酸泼尼松龙
Merck Number	7721
Wiswesser Line Notation	L E5 B666 OV AHTTT&J A1 CQ E1 FV1OV1 FQ
LabNetwork Molecule ID	LN01312579
InChI	InChI=1S/C23H30O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h6,8,10,16-18,20,26,28H,4-5,7,9,11-12H2,1-3H3/t16-,17-,18-,20+,21-,22-,23-/m0/s1

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产品应用

Synthetic corticosteroid; metabolically interconvertible with prednisone.

安全信息

RTECSTU4152500

GHS Symbol

Precautionary statements

P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P301+P310

Hazard statements

H300 Fatal if swallowed 吞食致命

Hazard Codes T

WGK Germany3

Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Signal word

Safety Statements

S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；

Risk Statements

R25 Toxic if swallowed 吞咽有毒

UN Number UN 2811 6.1/PG 3

Storage condition 储存温度-20°C

Packing GroupIII

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >240 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,713,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,713,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1800 mg/kg
SEX/DURATION            : female 2-19 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Fertility - abortion
REFERENCE :
   FESTAS Fertility and Sterility.  (American Fertility Soc., 608 13th Ave. S,
   Birmingham, AL 35282) V.1-    1950-  Volume(issue)/page/year: 22,735,1971

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 96 mg/kg
SEX/DURATION            : female 11-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   SEIJBO Senten Ijo.  Congenital Anomalies.  (Nippon Senten Ijo Gakkai, c/o
   Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho,
   Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher
   information, see CGANE7.  Volume(issue)/page/year: 13,245,1973

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 96 mg/kg
SEX/DURATION            : female 11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including

其他信息

用途一:适用于类风湿关节炎、风湿热、红斑狼疮、硬皮病、皮肌炎、急性淋巴白血病等。
图谱信息:醋酸泼尼松龙(52-21-1)核磁图( 1 HNMR) 醋酸泼尼松龙(52-21-1)红外图谱(IR2) 醋酸泼尼松龙(52-21-1)红外图谱(IR1) 醋酸泼尼松龙(52-21-1)核磁图( 13 CNMR) 醋酸泼尼松龙(52-21-1)质谱(MS)
MOL 文件:52-21-1.mol
醋酸泼尼松龙
Sigma Aldrich:52-21-1(sigmaaldrich)
TCI Shanghai:乙酸泼尼松龙 Prednisolone Acetate,>;95.0%(LC)(52-21-1)