7-Ethoxy-3H-Phenoxazin-3-One 7-乙氧基-3H-吩噁嗪-3-酮
CAS 5725-91-7 MFCD00037661
化学结构图
SMILES: CCOc1ccc2nc3ccc(=O)cc-3oc2c1
化学属性
| Mol. Formula | C14H11NO3 |
|---|---|
| Mol. Weight | 241.24 |
| Melting Point | 223-225°C |
| TSCA | No |
| Solubility | Soluble in DMSO (5 mg/mL), ethanol (5 mg/mL), chloroform, dichloromethane, DMF (5 mg/mL), alcohols, and methanol. Insoluble in water. |
| Boiling Point | |
| Flash Point | - |
别名和识别编码
| Chemical Name | 7-Ethoxy-3H-Phenoxazin-3-One |
|---|---|
| CAS Number | 5725-91-7 |
| Synonym | 7-Ethoxyresorufin {LY} 7-Ethoxyresorufin {} {LY} 7-Ethoxyresorufin {} {} {LY} 7-Ethoxyresorufin {} {} {} {LY} 7-Ethoxyresorufin {} {} {} {} {LY} 7-Ethoxyresorufin {} {} {} {} {} {LY} 7-Ethoxyresorufin {} {} {} {} {} {} {LY} 7-Ethoxyresorufin {} {} {} {} {} {} {} {LY} 7-Ethoxyresorufin {} {} {} {} {} {} {} {} {LY} 7-Ethoxyresorufin {} {} {} {} {} {} {} {} {} {LY} 7-Ethoxyresorufin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 7-Ethoxyresorufin {} {} {} {} {} {} {} {} {} {} {} {LY} 7-Ethoxyresorufin {} {} {} {} {} {} {} {} {} {} {} {} {LY} 7-Ethoxyresorufin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 7-Ethoxyresorufin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 7-Ethoxyresorufin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 7-Ethoxyresorufin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 7-Ethoxyresorufin |
| MDL Number | MFCD00037661 |
| PubChem Substance ID | 3294 |
| Beilstein Registry Number | 225973 |
| Chemical Name Translation | 7-乙氧基-3H-吩噁嗪-3-酮 |
| InChIKey | CRCWUBLTFGOMDD-UHFFFAOYSA-N |
| LabNetwork Molecule ID | LN01293567 |
| InChI | InChI=1S/C14H11NO3/c1-2-17-10-4-6-12-14(8-10)18-13-7-9(16)3-5-11(13)15-12/h3-8H,2H2,1H3 |
| Canonical SMILES | O=C1C=CC2=NC3=C(C=C(OCC)C=C3)OC2=C1 |
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分类
- {SNA} Alphabetical, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Detection, Fluorescent Enzyme Substrates, Fluorescent Enzyme Substrates for Flow Cytometry, Fluorescent Enzyme Substrates for Spectroscopy, Fluorescent Probes, Labels, Particles and Stains, Luminescent Compounds/Detection, R, Wavelength Index
- {SNA} Alphabetical, Biochemicals and Reagents, Detection, Fluorescent Enzyme Substrates, Fluorescent Enzyme Substrates for Flow Cytometry, Fluorescent Enzyme Substrates for Spectroscopy, Fluorescent Probes, Labels, Particles and Stains, Luminescent Compounds/Detection, R, Wavelength Index, 生物活性小分子,
- {SNA} Alphabetical,
产品应用
- 7-Ethoxyresorufin (7-ER) is a substrate used in environmental toxicology studies to monitor ethoxyresorufin-O-deethylase catalytic activity in the EROD assay. The EROD assay monitors the induction of the xenobiotic-metabolizing enzyme cytochrome P-450 (CYP) 1A1 and is a widely used biomarker for exposure of wildlife to substances that bind the aryl hydrocarbon (Ah) receptor. It provides evidence of receptor-mediated induction of cytochrome P450-dependant monooxygenases (the CYP1A subfamily specifically) by xenobiotic chemicals.
相关文献及参考
- [2]. Thomas K H Chang, et al. Enzymatic analysis of cDNA-expressed human CYP1A1, CYP1A2, and CYP1B1 with 7-ethoxyresorufin as substrate. Methods Mol Biol. 2006;320:85-90.
- Donato, M.T., et al.: Anal. Biochem., 213, 29 (1993),
- [1]. C G Li, et al. Inhibition of NO-medicate responses by 7-ethoxyresorufin, a substrate and competitive inhibitor of cytochrome P450. Br J Pharmacol. 1996 May;118(1):57-62.
- [1]. C G Li, et al. Inhibition of NO-medicate responses by 7-ethoxyresorufin, a substrate and competitive inhibitor of cytochrome P450. Br J Pharmacol. 1996 May;118(1):57-62.
- [2]. Thomas K H Chang, et al. Enzymatic analysis of cDNA-expressed human CYP1A1, CYP1A2, and CYP1B1 with 7-ethoxyresorufin as substrate. Methods Mol Biol. 2006;320:85-90.
安全信息
GHS Symbol
其他信息
- 7-Ethoxyresorufin is a fluorimetric substrate and suicide inhibitor of CYP (cytochrome P450). Also shown to inhibit several reductase enzymes, specifically CYPOR (NADPH-P450 reductase). The binding to CYP (cytochrome P450) is thought to inhibit the vasorelaxant response to acetylcholine. 7-Ethoxyresorufin has also demonstrated inhibition of NO synthesis by uncoupling neuronal NOS1 (nitric oxide synthase); it is a noncompetitive inhibitor of neuronal NOS1 with respect to L-arginine with a Ki value of 0.76 +/- 0.06 μM. 7-Ethoxyresorufin is a substate of CYP1A1.
- Dealkylase substrate for the microfluorimetric analysis of microsomal cytochrome P-450.
