Leukotriene D4
CAS 73836-78-9 MFCD00036839
化学结构图
SMILES: CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](N)C(=O)NCC(O)=O)[C@@H](O)CCCC(O)=O
化学属性
| Mol. Formula | C25H40N2O6S |
|---|---|
| Mol. Weight | 496.66 |
别名和识别编码
| Chemical Name | Leukotriene D4 |
|---|---|
| MDL Number | MFCD00036839 |
| PubChem Substance ID | 24896383 |
| CAS Number | 73836-78-9 |
| Synonym | LTD (sub 4) Leukotriene D Leukotriene D(sub 4) Leukotriene D4 |
| Chemical Name Translation |
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分类
- {SNA} Arachidonic Acid Cascade, Bioactive Small Molecule Alphabetical Index, Eicosanoids (Prostaglandins, Leukotrienes), Fatty Acyls, L, Leukotrienes, Lipids in Cell Signaling, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 脂类
- Arachidonic Acid Cascade, Bioactive Small Molecules, Biochemicals and Reagents,
- {SNA} Arachidonic Acid Cascade, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Eicosanoids (Prostaglandins, Leukotrienes), Fatty Acyls, L, Leukotrienes, Lipids, Lipids in Cell Signaling
相关文献及参考
- Piper, P., Formation and actions of leukotrienes. Physiol. Rev. 64 , 744, (1984) 摘要
- Samuelsson, B., Leukotrienes and lipoxins: structures biosynthesis and biological effects. Science 237 , 1171, (1987) 摘要
- Sjolander, A., Leukotriene D 4 and E 4 induce transmembrane signaling in human epithelial cells. Single cell analysis reveals diverse pathways at the G-protein level for the influx and the intracellular mobilization of Ca 2+ . J. Biol. Chem. 265 , 20976, (1990) 摘要
- Merck 14 ,5455
安全信息
GHS Symbol
- P301+P310
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P310+P330
- P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
- P370+P378
- P302+P352+P312
- H370 Causes damage to organs 导致器官损伤
- H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
- H301+H311+H331
- H331 Toxic if inhaled 吸入中毒
- H311 Toxic in contact with skin 皮肤接触中毒
- H301 Toxic if swallowed 吞食有毒
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
- R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性：吸入，皮肤接触和吞食都会产生十分严重的不可逆危险
- R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
- R11 Highly flammable 非常易燃
TYPE OF TEST : DNA inhibition TEST SYSTEM : Rodent - mouse Cells - not otherwise specified DOSE/DURATION : 10 nmol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 51,5573,1991
TYPE OF TEST : Unscheduled DNA synthesis TEST SYSTEM : Human Cells - not otherwise specified DOSE/DURATION : 100 nmol/L REFERENCE : JCINAO Journal of Clinical Investigation. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10021) V.1- 1924- Volume(issue)/page/year: 76,374,1985
