CAS 121-75-5 MFCD00036233-Malathion 马拉硫磷 TAO{mole}

Malathion 马拉硫磷

CAS 121-75-5 MFCD00036233

化学结构图

SMILES: CCOC(=O)CC(SP(=S)(OC)OC)C(=O)OCC

化学属性

Mol. Formula	C10H19O6PS2
Mol. Weight	330.38
Melting Point	2.85 ºC
Boiling Point	156 ºC
Density	1.0
Solubility	0.0145 G/100 ML
Flash Point	-18 °C
Stability	对光线敏感

别名和识别编码

Chemical Name	Malathion
CAS Number	121-75-5
Synonym	Diethyl ((dimethoxyphosphinothioyl)thio)butanedioate Malafor Diethyl mercaptosuccinate S-ester with O,O-dimethyl phosphorodithioate Forthion Oleophosphothion Malathyne 马拉硫磷 O,O-Dimethyl S-(1,2-dicarbethoxyethyl) dithiophosphate {Chemical Malacide Diethyl mercaptosuccinate, O,O-dimethyl phosphorodithioate Cimexan ortho Malathion Malathion E 5 O,O-Dimethyl S-(1,2-dicarbethoxyethyl)phosphorodithioate American Cyanamid 4,049 Hilthion S-[1,2-Bis(ethoxycarbonyl)ethyl] O,O-dimethyl phosphorodithioate 杀虫剂“4049” MALASPRAY(R) 马拉松 S-[1,2-Bis(ethoxycarbonyl)ethyl] O,O-dimethyl thiophosphate Malaspray 1,2-Di(ethoxycarbonyl)ethyl O,O-dimethyl phosphorodithioate 8059HC 高效磷乳油(40%) Diethyl (dimethoxyphosphinothioylthio)succinate {uni_hambu 1,2-bis(ethoxycarbonyl)ethyl o,o-dimethyl phosphorodithioate Diethyl mercaptosuccinate, O,O-dimethyl dithiophosphate, S-ester FYFANON/ACUAFIN/MAESTRO Extermathion Malataf O,O-二甲基 Maltox MLT O,O-二甲基-S-(1,2-二羰乙氧基乙基)二硫代磷酸酯 Malathyl LV concentrate & ULV concentrate {uni_ham butanedioic acid, [(dimethoxyphosphinothioyl)thio]-, diethyl ester O,O-dimeth Kypfos O,O-Dimethyldithiophosphate diethylmercaptosuccinate 杀虫剂4049 Carbetovur Moscarda Malathion LV concentrate S-(1,2-Bis(aethoxy-carbonyl)-aethyl)-O,O-dimethyl-dithiophosphat Fosfothion O,O-dimethyl Mercaptothion
MDL Number	MFCD00036233
PubChem Substance ID	4004
Beilstein Registry Number	1804525
EC Number	204-497-7
Chemical Name Translation	马拉硫磷
Wiswesser Line Notation	2OV1YVO2&SPS&O1&O1
InChI	InChI=1S/C10H19O6PS2/c1-5-15-9(11)7-8(10(12)16-6-2)19-17(18,13-3)14-4/h8H,5-7H2,1-4H3

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分类

{uni_hamburg} no charge; ester; 1fragment
{SNA} Analytical Standards, Analytical/Chromatography, CRM for chromatography, Certified Reference Materials (CRMs), Chromatography, Environmental Stand
{Chemicalbook} 农药: 杀虫（螨）剂: 有机磷杀虫
2000/60/EC, Acaricides, Alpha sort, Alphabetic, Analytical Standards, Analytical/Chromatography, Chromatography, EPA, Endocrine Disruptors (Draft), Environmental Standards, European Community: ISO, DIN and DL 152, H-M, Insecticides, M, MA - MD, Method Specific, Organophorous, Pesticides, Pesticides & Metabolites

产品应用

校准仪器和装置；评价方法；工作标准；质量保证/质量控制；其他。

安全信息

RTECSWM8400000

GHS Symbol

Precautionary statements

P501 Dispose of contents/container to..… 处理内容物/容器.....
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。

Hazard statements

H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
H317 May cause an allergic skin reaction 可能导致皮肤过敏
H302 Harmful if swallowed 吞食有害

Hazard Codes Xn;N Xn;N,N,Xn,F Xn,N

WGK Germany3

Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

Signal word Warning

Safety Statements

S24 Avoid contact with skin 避免皮肤接触；
S46 If swallowed, seek medical advice immediately and show this container or label 食入时，立即求医并出示容器/标签；
S37 Wear suitable gloves 戴适当手套；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
S2 Keep out of the reach of children 避免儿童触及；
S62 If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label where possible 吞食后不要催吐：立即求医并出示该容器或标签；

Risk Statements

R11 Highly flammable 非常易燃
R67 Vapours may cause drowsiness and dizziness 蒸汽可能导致嗜睡和昏厥
R65 Harmful: may cause lung damage if swallowed 若吞咽可能伤害肺部器官
R38 Irritating to skin 刺激皮肤
R22 Harmful if swallowed 吞咽有害
R50/53
R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应

UN Number 2783 UN 2783

Storage condition APPROX 4°C 储存温度2-8℃ 密封4℃保存。

Packing GroupIII

Hazard Class6.1(b)

Restrict 剧毒化学品

Warnings 危化品目录(2015) 危险化学品

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 193 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 129,699,1968

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mou

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Or

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 570 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : 600 mg/kg
TOXIC EFFECTS :
   Behavioral - food intake (animal)
REFERENCE :
   IJEBA6 Indian Journal of Experimental Biology.  (Publications & Information
   Directorate, CSIR, Hillside Rd., New Delhi 110 012, India)  V.1-    1963-
   Volume(issue)/page/year: 9,455,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - wild bird species
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AECTCV Archives of Environmental Contamination and Toxicology.
   (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 1 nmol/plate
REFERENCE :
   MSERDS Microbiology Series.  (Marcel Dekker, 270 Madison Ave., New York, NY
   10016)  V.1-    1973-  Volume(issue)/page/year: 5,93,

{hazard_c

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Multiple routes
TEST SYSTEM             : Fish - not otherwise specified
DOSE/DURATION           : 200 nL/L
REFERENCE :
   JFIBA9 Journal of Fish Biology.  (Academic Press, Inc., 1 E. First St.,
   Duluth, MN 55802) V.1-    1969-  Volume(issue)/page/year: 26,13,1985

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Administration onto the skin
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 500 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 204,283,1988

TYPE OF TEST            : Mutation in microorgan

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 303 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   10(Suppl 10),1,1987

TYPE OF TEST            : Specific locus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 4 ug/L
REFERENCE :
   FCTOD7 Food and Chemical Toxico

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 300 umol/L
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Health.  (Hemisphere Pub.,
   1025 Vermont Ave., NW, Washington, DC 20005)  V.1-    1975/76-

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 43920 mg/kg
SEX/DURATION            : multigenerations
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
   alive at weaning per # alive at day 4)
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
   Reproductive - Effects on Newborn - other postnatal measures or effects
REFERENCE :
   NATUAS Nature.  (Nature Subscription D

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 5550 mg/kg
SEX/DURATION            : female 91 day(s) pre-mating
                          female 1-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - body wall
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Health.  (Hemisphere Pub.,
   1025 Vermont Ave., NW, Washington, DC 20005)  V.1-    1975/76-
   Volume(issue)/page/year: 14,267,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 80 mg/kg
SEX/DURATION            : male 2 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   BECTA6 Bulletin of Environmental Contamination and Toxicology.
   (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
   07094)  V.1-    1966-  Volume(issue)/page/year: 15,458,1976

其他信息

用途一:属低毒非内吸性杀虫、杀螨剂，广泛用于农业和园艺，也可用作家庭卫生用药
方法一:酯化由顺丁烯二酸（或酐）与乙醇在硫酸催化下生成顺丁烯二酸二乙酯。采用苯作溶剂，利用苯、乙醇、水三元共沸脱水，以利于酯化反应进行。合成 O，O-二甲基二硫代磷酸（详见乐果的制备方法）与顺丁烯二酸二乙酯加成得马拉硫磷。O，O-二甲基硫代磷酸与顺丁烯二酸二乙酯的配比为1:1.15，反应温度55 ≤70℃，反应时间约7h。
MOL 文件:121-75-5.mol
上游原料:乙醇 --> 甲醇 --> 马来酸酐 --> 五硫化二磷 --> 苯乙醇 --> 二甲基硫 --> 搪玻璃反应锅 --> 马来酸 --> 石油原油 --> 乐果 --> 二甲基二硫代磷酸酯 --> 马来酸二乙酯
急救治疗:[1]用阿托品1～5mg皮下或静脉注射(按中毒轻重而定) [2]用解磷定0.4－1.2g静脉注射(按中毒轻重而定) [3]禁用吗啡、茶硷、吩噻嗪、利血平。 [4]误服立即引吐、洗胃、导泻(清醒时才能引吐)。
类别:农药
图谱信息:马拉硫磷(121-75-5)质谱(MS)
有机磷杀虫剂:对硫磷、甲基对硫磷、甲胺磷、乙酰甲胺磷、水胺硫磷、杀螟松、乐果、氧化乐果、内吸磷、敌敌畏、马拉硫磷、辛硫磷、久效磷、甲拌磷、毒死蜱、三唑磷、甲基异柳磷、敌百虫、伏杀磷、三硫磷、甲拌磷、稻丰散、乙硫磷、杀扑磷、丙溴磷、喹硫磷、敌百虫、敌敌畏、二溴磷、磷胺、倍硫磷、特普（TEPP）、治螟磷（苏化203）、异丙威。其中主要品种为毒死蜱，目前制约国内毒死蜱生产与发展最大的瓶颈不是产能过剩而是其专用中间体三氯吡啶醇钠合成过程中大量难以治理的含盐废水，因此未来开发重点将是通过四氯吡啶水解酸化路线合成三氯吡啶醇钠。
中毒症状:急性中毒多在12小时内发病，口服立即发病。轻度：头痛、头昏、恶心、呕吐、多汗、无力、胸闷、视力模糊、胃口不佳等，全血胆碱酯酶活力一般降至正常值的70－50% 中度：除上述症状外还出现轻度呼吸困难、肌肉震颤、瞳孔缩小、精神恍惚、行走不稳、大汗、流涎、腹疼、腹泻。重者还会出现昏迷、抽搐、呼吸困难、口吐白沫、大小便失禁，惊厥，呼吸麻痹。
灭火剂:水、泡沫、二氧化碳、砂土。
用途二:低毒、广谱的杀虫、杀螨剂。具有触杀、胃毒作用，也有微弱的熏蒸作用，无内吸作用。由于杀伤力
用途三:马拉硫磷是高效低毒杀虫、杀螨剂，防治范围广。不仅用于稻、麦、棉，而且因毒性低、残效短，也用于蔬菜、果树、茶叶，以及仓库的防虫。主要防治稻飞虱、稻叶蝉、棉蚜、棉红蜘蛛、麦粘虫、豌豆象、大豆食心虫、果树红蜘蛛、蚜虫、粉蚧壳虫、巢蛾、蔬菜黄条跳、菜叶虫、茶树上的多种蚧类，以及蚊、蝇幼虫和臭虫等。
毒性分级:高毒
使用方法:1．麦类作物害虫的防治防治粘虫、蚜虫、麦叶蜂，用45%乳油1000
{Chemica
原药:马拉硫磷又称马拉松，英文malathion，分子式C10H19O6PS2,纯品常温下为无色
Sigma Aldrich:121-75-5(sigmaaldrich)
原药:马拉硫磷又称马拉松，英文malathion，分子式C10H19O6PS2,纯品常温下为无色或浅黄油状液体，有蒜臭味，工业品带深褐色，有强烈气味。挥发性小，熔点2.85℃。微溶于水，可与大多数有机溶剂混溶。不稳定，在PH为5.0以下活PH7.0以上都容易水解失效，PH为12以上迅速分解，遇铁、铝、金属时也能促其分解。对光和热不稳定。马拉硫磷具有良好的触杀和一定的熏蒸作用，非内吸性杀虫杀螨剂。进入虫体后氧化成马拉氧磷，从而更能发挥毒杀作用，而进入温血动物时，则被在昆虫体内所没有的羧酸酯酶水解，因而失去毒性。马拉硫磷毒性低，残效期短，对刺吸式口器和咀嚼式口器的害虫都有效。适用于防治烟草、水稻、棉花、大豆、蔬菜、果树、林木、茶和桑树等作物上的鳞翅目、鞘翅目等昆虫。也可用于防治仓库害虫。
储运特性:库房通风低温干燥; 与氧化剂、食品添加剂分开存放
职业标准:TWA 10 毫克/立方米; STEL 20 毫克/立方米