CAS 834-28-6 MFCD00035039-Phenformin Hydrochloride 盐酸苯乙双胍 TAO{mole}

Phenformin Hydrochloride 盐酸苯乙双胍

CAS 834-28-6 MFCD00035039

化学结构图

SMILES: Cl.N=C(N)NC(=N)NCCc1ccccc1

化学属性

Mol. Formula	C10H16ClN5
Mol. Weight	242
Melting Point	175-178°C
Solubility	>=10 g/100 mL at 21 °C
Density	1.24

别名和识别编码

Chemical Name	Phenformin Hydrochloride
MDL Number	MFCD00035039
CAS Number	834-28-6
EC Number	212-637-3
Synonym	USAF VI-6 1-phenylaethylbiguanidhydrochlorid {Chem dbi-td 1-phenethylbiguanide diabis 1-Phenethylbiguanide hydrochloride azucaps 盐酸苯乙双胍 debinyl n-(2-phenylethyl)imidodicarbonimidic diamide N'-beta-Phenethylbiguanide hydrochloride Meltrol 降糖灵盐酸盐苯乙福明 {Chemicalb Biguanide, 1-phenethyl-, hydrochloride 1-Fenetilbiguanide cloridrato N-beta-Phenylethyl biguanide hydrochloride meltrol PHENFORMIN HYDROCHLORIDE 1-phenethyl-biguanidhydrochloride dbcomb beta-Phenethybiguanide PHENFORMIN HCL Imidodica {C 1-phenethylbiguanide hydrochloride PHENFORMINI H 苯乙双胍 PHENETHYLBIGUANIDE HYDROCHLORIDE n-beta-phenylethylbiguanideh Phenformin HCl No. 9113 1-Phenethyl 1-phenethyl-biguanid Dipar usafvi-6 降糖灵 DBI-TD PHENFORMIN Phenformine HCL 1-Phenylaethylbiguanid hydrochlorid N(sup 1)-beta-Phenethylbiguanide hydrochloride 1-苯乙胺双胍 n’-beta-phenethylbiguanidehydrochloride 1-(2 Phenoformine hydrochloride 盐酸苯乙福明 phenoforminehydrochloride db-retard beta-Phenethylbiguanide 苯乙双胍盐酸盐,降糖灵盐酸盐聚苯并咪唑 n-(2-phenylethyl)-imidodicarbonimidicdiamidmonohydrochloride n(sup1)-beta-phenethylbiguanidehydrochloride 1-phenethyl-biguanidmonohydrochloride Phenethylbiguanide hydrochloride N-(2-Phenylethyl)imidodic
PubChem Substance ID	13266
Chemical Name Translation	盐酸苯乙双胍
InChIKey	YSUCWSWKRIOILX-UHFFFAOYSA-N
Wiswesser Line Notation	MUYZMYUM&M2R &GH
LabNetwork Molecule ID	LN00223478
InChI	InChI=1S/C10H15N5.ClH/c11-9(12)15-10(13)14-7-6-8-4-2-1-3-5-8;/h1-5H,6-7H2,(H6,11,12,13,14,15);1H

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安全信息

Hazard Codes Xn

WGK Germany3

GHS Symbol

Hazard statements

H302 Harmful if swallowed 吞食有害

RTECSDU2200000

Signal word

Safety Statements

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

Risk Statements

R22 Harmful if swallowed 吞咽有害

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 17800 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#00094

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JACSAT Journal of the American Chemical Society.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
   20037)  V.1-    1879-  Volume(issue)/page/year: 81,3728,1959

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 407 mg/kg
TOXIC EFFECTS :
   Endocrine - hypoglycemia
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   14,393,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD691-490

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   24,181,1994

Precautionary statements

其他信息

MSDS 信息:1-Phenethylbiguanide hydrochloride(834-28-6).msds
MSDS 信息:Phenformin(114-86-3).msds
Sigma Aldrich:834-28-6(sigmaaldrich)
用途一:聚苯并咪唑可制成各种用品如玻璃布层压板、模塑料薄膜、胶粘剂、绝缘漆、泡沫塑料及纤维等。层压板可用于飞机和航天的雷达天线罩、印刷线路板等。还用于绝缘材料、隔离层、耐辐射材料等。
上游原料:多聚磷酸 --> N,N-二甲基乙酰胺 --> 双氰胺 --> 预聚物 --> 间苯二甲酰氯 --> 间苯二甲酸二苯酯 --> 盐酸联苯胺 --> 高沸点溶剂
方法一:聚苯并咪唑的制备一般有三种方法: 高温溶液缩聚法: 将3, 3 ' , 4, 4 ' -四氨基联苯胺盐酸盐与间苯二甲酸二苯酯。在高沸点溶剂和多磷酸存在下，于200℃反应数小时，用水沉淀聚合物，洗涤、干燥得预聚物。然后在250-300℃高温脱水环化得聚苯并咪唑。该法易制得高分子量产品。低温溶液缩聚法: 将3, 3 ' , 4, 4 ' -四氨基联苯与间苯二甲酰氯在二甲基乙酰胺等强极性溶剂中，以吡啶为酸吸收剂，于低温(0℃以下)进行缩聚制得预聚物，加入沉淀剂，分离、洗涤、干燥预聚物，再于250-300℃高温脱水环化制得聚苯并咪唑。熔融缩聚法: 将3, 3 ' , 4, 4 ' -四氨基联苯和间苯二甲酸二苯酯加入反应釜中，在氮气保护下，于260℃反应1-2h，脱苯酚生成聚氨基酰胺预聚物，经粉碎，再于385-400℃高真空脱水环化3-4h，可制得聚苯并咪唑。
用途二:本品为降血糖药，以成年型糖尿病的疗效约为88%，适用于各类型的糖尿病。小鼠口服LD50为450mg/kg。
方法二:由苯乙胺盐酸盐与双氰胺在142℃左右加热反应，经后处理、精制而得。
用途一:用作降血糖药
上游原料:双氰胺
Sigma Aldrich:114-86-3(sigmaaldrich)
MOL 文件:834-28-6.mol
MOL 文件:114-86-3.mol