CAS 106-87-6 MFCD00022354-3-(Oxiran-2-Yl)-7-Oxabicyclo[4.1.0]Heptane 二氧化乙烯基环己烯 TAO{mole}

3-(Oxiran-2-Yl)-7-Oxabicyclo[4.1.0]Heptane 二氧化乙烯基环己烯

CAS 106-87-6 MFCD00022354

化学结构图

SMILES: C1CC2OC2CC1C1CO1

化学属性

Mol. Formula	C8H12O2
Mol. Weight	140.18
Refractive index	n20/D 1.477(lit.)
Boiling Point	230-232 °C at 760 mmHg
Density	1.094 g/mL at 25 °C(lit.)
Solubility	溶于水。
Flash Point	107.22°C
Melting Point	-55 °C

别名和识别编码

Chemical Name	3-(Oxiran-2-Yl)-7-Oxabicyclo[4.1.0]Heptane
MDL Number	MFCD00022354
CAS Number	106-87-6
Synonym	3-(Oxiran-2-yl)-7-oxabicyclo[4.1.0]heptane {LY} 3-(Oxiran-2-yl)-7-oxabicyclo[4.1.0]heptane {} {LY} 3-(Oxiran-2-yl)-7-oxabicyclo[4.1.0]heptane {} {} {LY} 3-(Oxiran-2-yl)-7-oxabicyclo[4.1.0]heptane {} {} {} {LY} 3-(Oxiran-2-yl)-7-oxabicyclo[4.1.0]heptane {} {} {} {} {LY} 3-(Oxiran-2-yl)-7-oxabicyclo[4.1.0]heptane {} {} {} {} {} {LY} 3-(Oxiran-2-yl)-7-oxabicyclo[4.1.0]heptane {} {} {} {} {} {} {LY} 3-(Oxiran-2-yl)-7-oxabicyclo[4.1.0]heptane {} {} {} {} {} {} {} {LY} 3-(Oxiran-2-yl)-7-oxabicyclo[4.1.0]heptane {} {} {} {} {} {} {} {} {LY} 3-(Oxiran-2-yl)-7-oxabicyclo[4.1.0]heptane {} {} {} {} {} {} {} {} {} {LY} 3-(Oxiran-2-yl)-7-oxabicyclo[4.1.0]heptane {} {} {} {} {} {} {} {} {} {} {LY} 3-(Oxiran-2-yl)-7-oxabicyclo[4.1.0]heptane {} {} {} {} {} {} {} {} {} {} {} {LY} 3-(Oxiran-2-yl)-7-oxabicyclo[4.1.0]heptane {} {} {} {} {} {} {} {} {} {} {} {} {LY} 3-(Oxiran-2-yl)-7-oxabicyclo[4.1.0]heptane {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 3-(Oxiran-2-yl)-7-oxabicyclo[4.1.0
PubChem Substance ID	7833
EC Number	203-437-7
Beilstein Registry Number	106071
Chemical Name Translation	二氧化乙烯基环己烯
Wiswesser Line Notation	T36 BOTJ A- BT3OTJ
LabNetwork Molecule ID	LN00238998
InChI	InChI=1S/C8H12O2/c1-2-6-7(10-6)3-5(1)8-4-9-8/h5-8H,1-4H2
Canonical SMILES	C1(C2OC2)CCC3C(O3)C1

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产品应用

乙烯基环己烯二氧化物（VCD）作为一种卵巢毒素可用于研究其毒性。 VCD是用来研究其对卵巢滤泡及上皮细胞分化的毒性影响机制。

安全信息

GHS Symbol

WGK Germany1

Hazard statements

H351 Suspected of causing cancer 怀疑致癌
H331 Toxic if inhaled 吸入中毒
H311 Toxic in contact with skin 皮肤接触中毒
H301 Toxic if swallowed 吞食有毒

Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

RTECSRN8640000

Precautionary statements

P301+P310
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。

Signal word Danger

Hazard Codes T

Risk Statements

R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
R68/20/21/22

Safety Statements

S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
S24 Avoid contact with skin 避免皮肤接触；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；

Packing GroupIII

Hazard Class6.1(b)

UN Number UN 2810 6.1/PG 3

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 31500 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-362,1989

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 90 gm/kg/74W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   AIHAAP American Industrial Hygiene Association Journal.  (AIHA, 475 Wolf
   Ledges Pkwy., Akron, OH 44311)  V.19-    1958-  Volume(issue)/page/year:
   24,305,1963

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5000 mg/kg/10W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London,

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2800 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Blood - lymphoma, including Hodgkin's disease
   Skin and Appendages - tumors
REFERENCE :
   RARSAM Radiation Research, Supplement.  (New York, NY)  No.1-7, 1959-67.
   Discontinued.  Volume(issue)/page/year: 3,193,1963

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 620 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   UCDS** Union Carbide Data Sheet.  (Union Carbide Corp., 39 Old Ridgebury
   Rd., Danbury, CT 06817)  Volume(issue)/page/year: 9/19/1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2130 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   SCCUR* Shell Chemical Company.  Unpublished Report.  (2401 Crow Canyon Rd.,
   San Romon, CA 94583)  Volume(issue)/page/year: -,9,1961

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3216 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory stimulation
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-362,1989

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 800 ppm/4H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   SCCUR* Shell Chemical Company.  Unpublished Report.  (2401 Crow Canyon Rd.,
   San Romon, CA 94583)  Volume(issue)/page/year: -,9,1961

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 3730 pg/kg
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-362,1989

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 25 mmol/L
REFERENCE :
   BSIBAC Bolletino della Societe Italiana di Biologia Sperimentale.  (Casa
   Editrice Idelson, Via A. de Gasperi, 55, 80133 Naples, Italy)  V.2- 1927- 
   Volume(issue)/page/year: 56,1803,1980

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 125 mg/kg
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 6,235,1951

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 50 ug/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 66,367,1979

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Klebsiella pneumoniae
DOSE/DURATION           : 1 mmol/L
REFERENCE :

TYPE OF TEST            : Gene conversion and mitotic recombination
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 25 mmol/L
REFERENCE :
   BSIBAC Bolletino della Societe Italiana di Biologia Sperimentale.  (Casa
   Editrice Idelson, Via A. de Gasperi, 55, 80133 Naples, Italy)  V.2- 1927- 
   Volume(issue)/page/year: 56,1803,1980

TYPE OF TEST

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 4800 mg/kg
SEX/DURATION            : male 30 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   accessory glands
   Reproductive - Paternal Effects - other effects on male
REFERENCE :
   TOXID9 Toxicologist.  (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
   Akron, OH 44311) V.1-    1981-  Volume(issue)/page/year: 12,435,1992

Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {

其他信息

上游原料:甲苯 --> 碳酸钠 --> 三氯甲烷 --> 乙腈 --> 环己烷 --> 1,3-丁二烯 --> 过氧乙酸 --> 氧化亚铜 --> 十二烷基苯磺酸 --> 正丁烷 --> 过氧化氢苯甲酰 --> 1,10-菲罗啉(一水合物) --> 靛蓝 --> 无水高氯酸铁
急性毒性:口服- 大鼠 LD50: 2130 毫克/ 公斤; 吸入-大鼠 LC50: 800 ppm/4小时
类别:有毒物质
毒性分级:中毒
灭火剂:水, 二氧化碳, 泡沫, 干粉
爆炸物危险特性:聚合放热, 密闭容器可爆炸
用途一:用于电子显微镜
MSDS 信息:106-87-6.msds
职业标准:TWA 60 毫克/立方米; STEL 90 毫克/立方米
外观性质:透明水溶性液体, 有微弱烯烃气味。
可燃性危险特性:可燃;燃烧放出刺激烟雾
储运特性:库房低温, 通风, 干燥
Sigma Aldrich:106-87-6(sigmaaldrich)
MOL 文件:106-87-6.mol
刺激数据:皮肤- 兔 500 毫克重度