anthra(1,9-cd)pyrazol-6(2H)-one 吡唑蒽酮

CAS 129-56-6 MFCD00022289

化学结构图

129-56-6
SMILES: O=C1c2ccccc2-c2n[nH]c3cccc1c23

化学属性

Mol. FormulaC14H8N2O
Mol. Weight220.23 g/mol
Appearance Solid powder 黄色或深黄色粉末。
SolubilitySoluble in DMSO, not in water
Melting Point281~282℃

别名和识别编码

Chemical Name1,9-Pyrazoloanthrone
Synonym 1,9-PYRAZOLOANTHRONE 1,9-pyrazoloanthrone 1,9-吡唑并蒽酮 2h-dibenzo(cd,g)indazol-6-one ANTHRAPYRAZOLONE Anthra[1,9-cd]pyrazol-6(2H)-one NSC-75890 NSC75890 SP600125 anthra(1,9-cd)pyrazol-6(2H)-one pyrazolanthrone {} {} {PubChem} NSC75890 {} {} {} {PubChem} NSC-75890 {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
MDL NumberMFCD00022289
PubChem Substance ID8515
EC Number204-955-6
CAS Number129-56-6
Chemical Name Translation吡唑蒽酮
Reaxys-RN746890
Wiswesser Line NotationT C6665 1A P IV OMNJ
Beilstein Registry Number0746890
LabNetwork Molecule IDLN00227162
InChIInChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16)
FormulaC14H8N2O
IUPAC Namedibenzo[cd,g]indazol-6(2H)-one
InChIKeyACPOUJIDANTYHO-UHFFFAOYSA-N
Canonical SMILESO=C1C2=C3C(NN=C3C4=CC=CC=C14)=CC=C2
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分类

  • {SNA} Bioactive Small Molecules, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, Protein Kinase Inhibitors, S, Serine/Threonine Kinase Biology,
  • {SNA} Bioactive Small Molecule Alphabetical Index, Kinase/Phosphatase Biology, Protein Kinase Inhibitors, S, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, c-Jun N-Terminal Kinase (JNK), 生物活性小分子, 细胞信号转导和神经科学,
  • {S
  • {SNA} Bioactive Small Molecule Alphabetical Index, Kinase/Phosphatase Biology, Protein Kinase Inhibitors, S, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, c-Jun N-Terminal Kinase (JNK), 生物活性小分子, 细胞信号转导和神经科学,

产品应用

  • SP-600125 is a specific JNK inhibitor. SP600125 kills p53-deficient cells more efficiently than their p53-proficient counterparts, in vitro. Similar observations were obtained in vivo, in mice carrying p53-deficient and -proficient human xenografts.

相关文献及参考

  • Walshe, T., et al., Inhibition Of VEGF Or TGF-β Signaling Activates Endothelium And Increases Leukocyte Rolling Arterioscler. Thromb. Vasc. Biol. 29 , 1185-1192, (2009) 摘要
  • Chaveroux, C., et al., Identification Of A Novel Amino Acid Response Pathway Triggering ATF2 Phosphorylation In Mammals. Mol. Cell. Biol. 29 , 6515-26, (2009) 摘要
  • Han, Z., et al, c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. J. Clin. Invest. 108 , 73-81, (2001) 摘要
  • Huber, M.D., et al., Overlapping Functions Of Nuclear Envelope Proteins NET25 (Lem2) And Emerin In Regulation Of Extracellular Signal-regulated Kinase Signaling In Myoblast Differentiation. Mol. Cell. Biol. 29 , 5718-28, (2009) 摘要
  • Steinberg R, et. al., A protein kinase Cepsilon-anti-apoptotic kinase signaling complex protects human vascular endothelial cells against apoptosis through induction of Bcl-2. J. Biol. Chem. , 32288-97, (2007) 摘要
  • Walshe, T.E., et al., Inhibition Of VEGF Or TGF-{beta} Signaling Activates Endothelium And Increases Leukocyte Rolling. Arterioscler. Thromb. Vasc. Biol. 29 , 1185-92, (2009) 摘要
  • Bauler LD, Duckett CS, O'Riordan MX, XIAP regulates cytosol-specific innate immunity to Listeria infection. PLoS Pathog. , e1000142, (2008) 摘要
  • Das R, et. al., Structural inference of native and partially folded RNA by high-throughput contact mapping. Proc. Natl. Acad. Sci. U. S. A. , 4144-9, (2008) 摘要
  • Bennett, B.L., et al, SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc. Na

安全信息

GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352
  • P304+P340
  • P305 IF IN EYES: 如果进入眼睛
  • P305+P351+P338
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P332+P313
  • P332+P317
  • P337+P313
  • P337+P317
  • P338 Remove contact lenses, if present and easy to do. Continue rinsing. 如果戴隐形眼睛并容易摘掉的话，取出隐形眼镜，继续冲洗。
  • P351 Rinse cautiously with water for several minutes. 小心地用水冲洗几分钟。
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P362+P364
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard Codes Xi
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
WGK Germany3
Signal word Warning
RTECSCB4585000
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Storage condition 0-10 0-10°C 2-8°C Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). 储存温度-20°C
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 178 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#00640

其他信息

  • 可燃性危险特性:可燃; 燃烧产生有毒氮氧化物烟雾
  • 储运特性:库房通风低温干燥
  • 毒性分级:中毒
  • color:yellow
  • Sigma Aldrich:129-56-6(sigmaaldrich)
  • MOL 文件:129-56-6.mol
  • 下游产品:还原黑8
  • 用途一:用作染料中间体，可用来生产还原灰M等
  • 1,9-PYRAZOLOANTHRONE
  • 急性毒性:静脉-小鼠 LD50: 178 毫克/公斤
  • 灭火剂:干粉,泡沫,沙土,二氧化碳, 雾状水
  • 类别:有毒物品

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Kinase/Phosphatase Biology - Cell Signaling and Neuroscience
  5. Serine/Threonine Kinase Biology - Kinase/Phosphatase Biology
  6. Serine/Threonine Kinase Inhibitors - Serine/Threonine Kinase Biology
  7. c-Jun N-Terminal Kinase (JNK) - Serine/Threonine Kinase Inhibitors
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Kinase/Phosphatase Biology - Cell Signaling and Neuroscience
  5. Serine/Threonine Kinase Biology - Kinase/Phosphatase Biology
  6. Serine/Threonine Kinase Inhibitors - Serine/Threonine Kinase Biology
  7. c-Jun N-Terminal Kinase (JNK) - Serine/Threonine Kinase Inhibitors
  1. Medical Research Areas
  2. MARK
  3. JNK

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