Rottlerin 粗糠紫苦素
CAS 82-08-6 MFCD00017361
化学结构图
SMILES: CC(=O)c1c(O)c(C)c(O)c(Cc2c(O)c3c(c(C(=O)C=Cc4ccccc4)c2O)OC(C)(C)C=C3)c1O
化学属性
| Mol. Formula | C30H28O8 |
|---|---|
| Mol. Weight | 517 |
| Density | 1.422 |
| Melting Point | >200 |
别名和识别编码
| Chemical Name | Rottlerin |
|---|---|
| Synonym | (E)-1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-2-propen-1-one 1-[6-[(3-Acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-2-propen-1-one 1-[6-[(3-Acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-2-propen-1-one Mallotoxin 1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2h-1-benzopyran-8-yl]-3-phenyl-2-propen-1-one 2-Propen-1-one, 1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-, (2E)- 3'-[(8-CINNAMOYL-5,7-DIHYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-6-YL)METHYL]-2',4',6'-TRIHYDROXY-5'-METHYLACETOPHENONE 3'-[(8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2',4',6'-trihydroxy-5'-methylacetophenone {Pub |
| CAS Number | 82-08-6 |
| EC Number | 201-395-4 |
| Beilstein Registry Number | 0070757 |
| MDL Number | MFCD00017361 |
| PubChem Substance ID | 5281847 |
| Chemical Name Translation | 粗糠紫苦素 |
| Wiswesser Line Notation | T66 BO CHJ C1 C1 GQ H1R BQ DQ FQ C1 EV1& IQ JV1U1R |
| LabNetwork Molecule ID | LN01327195 |
| InChI | InChI=1S/C30H28O8/c1-15-24(33)19(27(36)22(16(2)31)25(15)34)14-20-26(35)18-12-13-30(3,4)38-29(18)23(28(20)37)21(32)11-10-17-8-6-5-7-9-17/h5-13,33-37H,14H2,1-4H3/b11-10+ |
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分类
- {SNA} Autophagy, Autophagy Activators, Bioactive Small Molecules, Biochemicals and Reagents, Cell Signaling and Neuroscience, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Kinase/Phosphatase Biology, P to Q, Protein Kinase C, Calcium/Calmodulin-dependent protein Kinase (PKC and CaMK), Protein Kinase Inhibitors, Protein Kinase, Calmodulin dependent, Protein kinase C, R, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, 细胞生物学
- {SNA} Autophagy, Autophagy Activators, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signali
相关文献及参考
- Gschwendt, M., et al. Biochem. Biophys. Res. Commun. 199 , 93, (1994) 摘要
- Gschwendt, M., et al. FEBS Lett. 338 , 85, (1994) 摘要
- Zakharov, S.I., et al., Activation of the BK (SLO1) Potassium Channel by Mallotoxin J. Biol. Chem. 35 , 30882-30887, (2005) 摘要
- Haoyu Zeng, et al., , Mallotoxin Is a Novel Human Ether-a-go-go-Related Gene (hERG) Potassium Channel Activator J. Pharmacol. Exp. Ther. 319 , 957-962, (2006) 摘要
- Crowe, A., et al., Identification Of Aminothienopyridazine Inhibitors Of Tau Assembly By Quantitative High-throughput Screening. Biochemistry 48 , 7732-45, (2009) 摘要
- Merck 14 ,8272
安全信息
GHS Symbol
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
- R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
- R22 Harmful if swallowed 吞咽有害
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- P301+P312
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 750 mg/kg TOXIC EFFECTS : Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : IJPPAZ Indian Journal of Physiology and Pharmacology. (All India Institute of Medical Sciences, Dept. of Physiology, Ansari Nagar, New Delhi 110 029, India) V.1- 1957- Volume(issue)/page/year: 3,168,1959
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 120 mg/kg SEX/DURATION : female 6 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles) REFERENCE : IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913- Volume(issue)/page/year: 48,52,1960
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 375 mg/kg SEX/DURATION : female 15 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - menstrual cycle changes or disorders REFERENCE : IJPPAZ Indian Journal of Physiology and Pharmacology. (All India Institute of Medical Sciences, Dept. of Physiology, Ansari Nagar, New Delhi 110 029, India) V.1- 1957- Volume(issue)/page/year: 3,168,1959
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 150 mg/kg SEX/DURATION : female 6 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) REFERENCE : IJPPAZ Indian Journal of Physiology and Pharmacology. (All India Institute of Medical Sciences, Dept. of Physiology, Ansari Nagar, New Delhi 110 029, India) V.1- 1957- Volume(issue)/page/year: 3,168,1959
其他信息
- 粗糠柴苦素价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 328490100 粗糠柴苦素 Rottlerin 98% 10 MG 1346元
- Sigma Aldrich:82-08-6(sigmaaldrich)
- Acros Organics:粗糠柴苦素 Rottlerin, 98%(82-08-6)
- MOL 文件:82-08-6.mol
