CAS 520-18-3 MFCD00016938-3,4',5,7-Tetrahydroxyflavone 3,4',5,7-四羟基黄酮 TAO{mole}

3,4',5,7-Tetrahydroxyflavone 3,4',5,7-四羟基黄酮

CAS 520-18-3 MFCD00016938

化学结构图

SMILES: O=c1c(O)c(-c2ccc(O)cc2)oc2cc(O)cc(O)c12

化学属性

Mol. Formula	C15H10O6
Mol. Weight	286
Density	1.688
Melting Point	277
Solubility	ethanol: 20 mg/mL
Appearance	powder

别名和识别编码

Chemical Name	3,4',5,7-Tetrahydroxyflavone
CAS Number	520-18-3
Synonym	莰菲醇 5,7-四羟基黄酮 Trifolitin 4' 4,5,7三羟黄酮醇 {hazar 莰菲醇，3 猫眼草素I 山柰酚山茶酚 KAEMPFEROL 3,5,7,4'-TETRAHYDROXYFLAVONE kaempherol Kampherol 崁非醇山柰酚-3 Kaempherol kempferol pelargidenolon 山柰素 Kaempferol c.i.75640 Rhamnolutein 3,4',5,7-四羟基黄酮 3,4',5,7-TETRAHYDROXYFLAVONE 3,5,7-TRIHYDROXY-2-[4-HYDROXY-PHENYL]-4H-1-BENZOPYRAN-4-ONE {C { 3,4',5,7-Tetrahydroxyflavone; 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one 3,4′,5,7-Tetrahydroxyflavone, 3,5,7-Trihydroxy-2-(4-hydroxypheny 山奈酚(素) C.I. 75640 3,4′,5,7-Tetrahydroxyflavone, 3
MDL Number	MFCD00016938
Beilstein Registry Number	304401
EC Number	208-287-6
Reaxys-RN	304401
PubChem Substance ID	5280863
Merck Number	5274
Chemical Name Translation	3,4',5,7-四羟基黄酮
Wiswesser Line Notation	T66 BO EVJ CR DQ& DQ GQ IQ
InChI	InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H
LabNetwork Molecule ID	LN00008740

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分类

{SNA} Antioxidant and Free Radical Scavengers, Bioactive Small Molecules, Biochemicals and Reagents, Bioflavonoids, Cancer Metabolism, Cell Biology, Chemopreventive Agents, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Fatty Acid Metabolism in Oncogenesis, Fatty Acid Synthase (FAS) Inhibitors, Flavonoids, Flavonols, and Flavanols, Inhibitors and Activators of Fatty Acid Metabolism, K, Nutrition Research, Phytochemicals by Chemical Classification, Phytoestrogens, R to Z, Topoisomerase I, 癌症研究
{SNA} Aesculus, Allium, Alphabetical, Ana

产品应用

一种黄酮醇。能使佛波醇酯处理的小鼠成纤维细胞或v-H-ras-转化的 NIH 3T3细胞变形后的恢复。能显著诱导核DNA退化，同时伴随脂类的过氧化反应。抑制拓扑异构酶I催化的DNA再连接。

安全信息

GHS Symbol

Precautionary statements

P301+P310
P281 Use personal protective equipment as required. 使用所需的个人防护装备。

Hazard statements

H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
H301 Toxic if swallowed 吞食有毒

WGK Germany3

Signal word

RTECSLK9275200

Safety Statements

S36 Wear suitable protective clothing 穿戴适当的防护服；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Hazard Codes T

Packing GroupIII

UN Number

Storage condition -20°C 储存温度 -20°C

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 25 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 113,45,1983

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 50 mg/L
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   33,3823,1984

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 100 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 89,95,1981

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacter

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 20 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 246,205,1991

TYPE OF TEST            : Micronucleus test
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 10 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 246,205,1991

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 20 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 246,205,1991

其他信息

色指数:75640
Sigma Aldrich:520-18-3(sigmaaldrich)
MSDS 信息:3,4',5,7-Tetrahydroxyflavone(520-18-3).msds
图谱信息:山奈酚(520-18-3)红外图谱(IR2) 山奈酚(520-18-3)核磁图( 1 HNMR) 山奈酚(520-18-3)质谱(MS) 山奈酚(520-18-3)红外图谱(IR1)
color:yellow
存储注意事项:光敏感;空气敏感
F:8-10-23
MOL 文件:520-18-3.mol
TCI Shanghai:山奈酚 Kaempferol,>;97.0%(LC)(520-18-3)
检测方法:HPLC,NMR
山奈酚价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 K0018 山奈酚水合物 Kaempferol Hydrate 1G 8930元 2014/06/02 K0018 山奈酚水合物 Kaempferol Hydrate 100MG 1580元
用途一:一种黄酮醇。能使佛波醇酯处理的小鼠成纤维细胞或v-H-ras-转化的 NIH 3T3细胞变形后的恢复。能显著诱导核DNA退化，同时伴随脂类的过氧化反应。抑制拓扑异构酶I催化的DNA再连接。