Hypericin 金丝桃素
CAS 548-04-9 MFCD00016683
化学结构图
SMILES: Cc1cc(=O)c2c(O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(O)c7c(=O)cc(C)c8c1c2c(c34)c(c65)c78
化学属性
| Mol. Formula | C30 |
|---|---|
| Mol. Weight | 504 |
| Melting Point | ca 320° dec. |
| TSCA | No |
| Density | 1.915 |
| Stability | 对光敏感 |
别名和识别编码
| Chemical Name | Hypericin |
|---|---|
| Synonym | 1,3,4,6,8,13-Hexahydroxy-10,11-di-methylphenanthro(1,10,9,8,opqra)perylene-7,14-dione; 4,5,7,4',5',7'-Hexahydroxy-2,2'-dimethylnaphthodianthrone 4,4',5,5',7,7'-Hexahydroxy-2,2'-dimethylnaphthodianthrone 金丝桃素 来源于贯叶连翘 4,5,7,4,5,7--2,2- 4,4',5,5',7,7'-Hexahydroxy-2,2'-dimethylnaphthodianthroneHypericum red 4,5,7,4′,5′,7′-六羟基-2,2′-二甲基萘并二蒽酮 Cyclo werrol Hypericum red 4,5,7,4′,5′,7′-六羟基-2,2′-二甲基萘并二蒽酮 |
| MDL Number | MFCD00016683 |
| Beilstein Registry Number | 1917913 |
| CAS Number | 548-04-9 |
| EC Number | 208-941-0 |
| Merck Number | 14,4863 |
| PubChem Substance ID | 3663 |
| Chemical Name Translation | 金丝桃素 |
| InChI | InChI=1S/C30H16O8/c1-7-3-9(31)19-23-15(7)16-8(2)4-10(32)20-24(16)28-26-18(12(34)6-14(36)22(26)30(20)38)17-11(33)5-13(35)21(29(19)37)25(17)27(23)28/h3-6,33-38H,1-2H3 |
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信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- {SNA} Alphabetical, Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Cell Biology, Chromatography, E - H, H, HU - HZ, Hypericum, Hypericum perforatum (St John's wort), Life Sciences Standards, Nutrition Research, Phyto Primary Pharmaceutical Reference Standards, Phytochemicals by Plant (Food/Spice/Herb), Phytopharma Standards, Quinones, Standards by Plant Genus, Substance Classification
- {SNA} Glycosides, Including Glucosinolates, Hypericum perforatum (St John's wort), Other Biochemical, Phytochemicals by Chemical Classification, Phytochemicals by Plant (Food/Spice/Herb),
- {SNA} Glycosides, Inclu
产品应用
- 金丝桃素是贯叶连翘光反应的色素，在590-600纳米被光激活，呈现高度毒性（Amax = 592纳米）。在体外和体内它均诱导癌细胞凋亡，是一种强力的抗病毒药物。它激活化合物，抑制蛋白激酶C，不可逆转的损害sarco/内质网和其他细胞膜，降低细胞的pH值，抑制线粒体的功能。
- 医学上金丝桃素具有抗病毒、抗癌、抗抑郁等功能，已用于治疗抑郁，爱滋病，肝炎，癌症等，近年来的研究表明还可高效作用于禽流感H5N1型病毒。金丝桃素具有光敏活性和光动作用，这使它有可能作为一种新的光敏物质应用于癌症的光化学治疗，同时也可初步解释其抗病毒机制。金丝桃素能抑制HIV及其它一些反转录病毒，它通过影响HIV复制循环的装配与释放过程抑制HIV活性，丰富了抗AIDS药物的机制。
相关文献及参考
- Inhibitor of protein kinase C: Biochem Biophys. Res. Commun., 165, 1207 (1989); Photochem. Photobiol., 82, 720 (2006). Antiviral and antitumour photosensitizer: Photochem. Photobiol., 54, 95 (1991); Curr. Drug Targets, 3, 55 (2002).
- Merck:14,4863 Beilstein: 8,IV,3761
- Inhibitor of protein kinase C: Biochem Biophys. Res. Commun., 165, 1207 (1989); Photochem. Photobiol., 82, 720 (2006). Antiviral and antitumour photosensitizer: Photochem. Photobiol., 54, 95 (1991); Curr. Drug Targets, 3, 55 (2002).
- Merck:14,4863
安全信息
GHS Symbol
- P301+P310
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- H317 May cause an allergic skin reaction 可能导致皮肤过敏
- H301 Toxic if swallowed 吞食有毒
- H302 Harmful if swallowed 吞食有害
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R22 Harmful if swallowed 吞咽有害
- R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
其他信息
- 金丝桃素是贯叶连翘的主要活性成分。
