4-Nitro-2-Picoline N-Oxide 4-硝基-2-甲基吡啶-N-氧化物
CAS 5470-66-6 MFCD00014625
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分类
- Nitric Oxide Reagents
- Aromatics
- Heterocycles
- {SNA} Building Blocks, C6, Chemical Synthesis, Heterocyclic Building Blocks, Pyridines
产品应用
- A nitroheterocyclic compound and its potential suitability as radiosensitizer for cancer radiotherapy.
相关文献及参考
- Walton, M., et al.: Biochem. Pharmacol., 36, 887 (1987),
- Beilstein:20(5)5,503
安全信息
GHS Symbol
- S22 Do not breathe dust 不要吸入粉尘;
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S36 Wear suitable protective clothing 穿戴适当的防护服;
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
- R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
- R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P302+P350
- P302+P352+P332+P313+P362+P364
- P305+P351+P338
- P305+P351+P338+P337+P313
- P332+P313
- P337+P313
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
- H315 Causes skin irritation 会刺激皮肤
- H332 Harmful if inhaled 吸入有害
- H302 Harmful if swallowed 吞食有害
- H312 Harmful in contact with skin 皮肤接触有害
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H351 Suspected of causing cancer 怀疑致癌
- H319 Causes serious eye irritation 严重刺激眼睛
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1800 mg/kg/15W-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application REFERENCE : GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75, 1907-84. For publisher information, see JJCREP. Volume(issue)/page/year: 70,799,1979
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 500 umol/L REFERENCE : GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75, 1907-84. For publisher information, see JJCREP. Volume(issue)/page/year: 70,799,1979
TYPE OF TEST : DNA damage TEST SYSTEM : Rodent - mouse Fibroblast DOSE/DURATION : 50 umol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 35,521,1975
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 250 nmol/plate REFERENCE : GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75, 1907-84. For publisher information, see JJCREP. Volume(issue)/page/year: 70,799,1979
其他信息
- color:yellow to light orange
- 用途一:医药中间体。
- MSDS 信息:2-Methyl-4-nitropyridine 1-oxide(5470-66-6).msds
- Sigma Aldrich:5470-66-6(sigmaaldrich)
- Alfa Aesar:4-硝基-2-甲基吡啶N-氧化物,98% 4-Nitro-2-picoline N-oxide, 98%(5470-66-6)
- 2-甲基-4-硝基吡啶-N-氧化物价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 M2114 2-甲基-4-硝基吡啶N-氧化物 2-Methyl-4-nitropyridine N-Oxide 25G 3180元 2014/06/02 M2114 2-甲基-4-硝基吡啶N-氧化物 2-Methyl-4-nitropyridine N-Oxide 5G 889元 2010/05/25 L06614 4-硝基-2-甲基吡啶 N-氧化物, 98% 4-Nitro-2-picoline N-oxide, 98% 5g 918元
- MOL 文件:5470-66-6.mol
- 检测方法:HPLC,NMR
- 下游产品:4-羟基-2-甲基吡啶 --> 4-羟基吡啶-2-羧酸 --> 2-甲基-4-氨基吡啶 --> 4-氨基吡啶-2-甲酸 --> 4-溴吡啶-2-羧酸 --> 4-溴-2-甲基吡啶 --> 4-乙酰氨基吡啶-2-甲酸 --> 2-甲基-4-乙酰氨基吡啶 --> 2-甲基-4-硝基吡啶