CAS 142-46-1 MFCD00014471-Hydrazodicarbothioamide 二硫代脲 TAO{mole}

Hydrazodicarbothioamide 二硫代脲

CAS 142-46-1 MFCD00014471

化学结构图

SMILES: NC(=S)NNC(N)=S

化学属性

Mol. Formula	C2H6N4S2
Mol. Weight	150.22
Melting Point	212°C
TSCA	Yes
Appearance	双硫脲纯品为白色结晶固体，m.p.206～208℃，在热水中有一定的溶解度，易溶于吡啶、三乙胺、二甲基甲酰胺及一般溶剂中。
Density	1.556

别名和识别编码

Chemical Name	Hydrazodicarbothioamide
MDL Number	MFCD00014471
CAS Number	142-46-1
EC Number	205-537-6
Beilstein Registry Number	1723178
PubChem Substance ID	87567830
Synonym	bithiourea 2,5-二硫代脲 bisthiocarbamylhydrazine USAF B-55 1,2-HYDRAZINEDICARBOTHIOAMIDE DITHIOCARBAMOYL HYDRAZINE 1,2-HYDRAZINE CARBOTHIOAMIDE usafb-44 usafek-p-6281 2,5-二硫代二脲 Bis(thiourea) 1,2-HYDRAZINE-O-DICARBOTHIOAMIDE 2,5-dithio-biure usafb-55 DITHIOBIUREA 1,2-Hydrazinedicarbothioamide; 2,5-Dithiobiurea 2,5-二硫代联二脲 1,2-Hydrazinedicarbothioamide 2,5-Dithiobiurea ZERENEX ZX007400 2,5-dithiodiurea 2,5-DITHIOBIUREA Bisthiocarbamyl hydrazine n,n’-bisthiocarbamylhydrazine 双硫脲 DITHIOUREA BISTHIOUREA nci-c03009 DITHIODIUREA TIMTEC-BB SBB008379 2,5-二硫二脲 1,2-二(氨基硫代甲酰)肼 NCI-C03009 N,N'-Bisthiocarbamyl hydrazine
Reaxys-RN	1723178
Chemical Name Translation	二硫代脲
Wiswesser Line Notation	SUYZMMYZUS
LabNetwork Molecule ID	LN00223016

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产品应用

农药和医药中间体。

安全信息

RTECSEC1460000

Safety Statements

S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36 Wear suitable protective clothing 穿戴适当的防护服；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R22 Harmful if swallowed 吞咽有害

WGK Germany3

GHS Symbol

Precautionary statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P302+P350
P302+P352+P332+P313+P362+P364
P305+P351+P338
P305+P351+P338+P337+P313
P332+P313
P337+P313
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用

Signal word Warning

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H319 Causes serious eye irritation 严重刺激眼睛
H335 May cause respiratory irritation 可能导致呼吸道刺激

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes Xi

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 655 gm/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-132,1979

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1310 gm/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-132,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD277-689

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCNSA6 National Academy of Sciences, National Research Council,
   Chemical-Biological Coordination Center, Review.  (Washington, DC)
   Volume(issue)/page/year: 5,46,1953

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 145 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   10(Suppl 10),1,1987

其他信息

图谱信息:2,5-二硫代联二脲(142-46-1)核磁图( 13 CNMR) 2,5-二硫代联二脲(142-46-1)质谱(MS) 2,5-二硫代联二脲(142-46-1)红外图谱(IR1) 2,5-二硫代联二脲(142-46-1)红外图谱(IR2)
下游产品:川化-108 --> 2-氨基-5-巯基-1,3,4-噻二唑
上游原料:硫氰酸铵 --> 硫酸肼 --> 硫氰酸胺
类别:农药
用途一:双硫脲是杀菌剂叶枯唑的中间体。
方法一:其制备方法是在反应釜中于搅拌下投入湿基硫酸肼，加入催化剂少量，然后再投入硫氰酸铵，开夹套蒸汽加热回流3.5h，冷却，放料，过滤，用水洗涤，真空吸滤至干，得成品。
Alfa Aesar:二硫代脲,97% 2,5-Dithiobiurea, 97%(142-46-1)
用途二:农药和医药中间体。
毒性分级:高毒
急性毒性:口服-大鼠 LD50: 500 毫克/公斤;腹腔-小鼠 LD50: 100 毫克/公斤
储运特性:库房通风低温干燥; 与氧化剂、酸类分开存放
可燃性危险特性:受热分解排放有毒氮氧化物和硫氧化物
灭火剂:水,干粉、干砂、二氧化碳、泡沫、1211灭火剂
方法二:硫酸肼和硫氰酸胺经缩合、重排出得。
2,5-二硫代联二脲价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 D1308 2,5-二硫代联二脲 2,5-Dithiobiurea 25G 383元 2014/06/02 D1308 2,5-二硫代联二脲 2,5-Dithiobiurea 10G 195元 2010/05/25 A16667 二硫代脲, 97% 2,5-Dithiobiurea, 97% 25g 344元
TCI Shanghai:2,5-二硫代联二脲 2,5-Dithiobiurea(142-46-1)
Sigma Aldrich:142-46-1(sigmaaldrich)
MOL 文件:142-46-1.mol
几乎不溶于水，溶于热水。