CAS 51-05-8 MFCD00013000-Procaine Hydrochloride 4-氨基苯甲酸-2-(二乙氨基)乙酯单盐酸盐 TAO{mole}

Procaine Hydrochloride 4-氨基苯甲酸-2-(二乙氨基)乙酯单盐酸盐

CAS 51-05-8 MFCD00013000

化学结构图

SMILES: CCN(CC)CCOC(=O)c1ccc(N)cc1.Cl

化学属性

Mol. Formula	H2NC6H4CO2CH2CH2N(C2H5)2·HCl
Mol. Weight	273
Melting Point	154.0 to 157.0 deg-C
TSCA	Yes
Boiling Point	195-196
Solubility	可溶
Density	1.422
Stability	对光和空气敏感

别名和识别编码

Chemical Name	Procaine Hydrochloride
Synonym	Sevicaine Procaine hydrochloride 4-氨基苯甲酸-2-（二乙氨基）乙酯盐酸 Paracain Anesthesol Neocaine Cetain Benzoic acid, 4-amino-, 2-(diethylamino)ethyl ester, monohydrochloride Aminocaine 2-(Diethylamino)ethyl 4-aminobenzoate hydrochloride Anestil Diethylaminoethanol 4-aminobenzoate hydrochloride Eugerase Lactocaine 4-Aminobenzoic Acid 2-(Diethylamino)ethyl Ester Hydrochloride; 2-(Diethylamino)ethyl 4-Aminobenzoate Hydrochloride Isocaine-asid Syncaine 2-二乙基氨基乙基 4-氨基苯甲酸酯盐酸盐, 99%
MDL Number	MFCD00013000
CAS Number	51-05-8
EC Number	200-077-2
Merck Number	7757
PubChem Substance ID	5795
Beilstein Registry Number	14(4)1138
Reaxys-RN	3917802
Chemical Name Translation	4-氨基苯甲酸-2-(二乙氨基)乙酯单盐酸盐
Wiswesser Line Notation	ZR DVO2N2&2 &GH
LabNetwork Molecule ID	LN00335077
InChI	InChI=1S/C13H20N2O2.ClH/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11;/h5-8H,3-4,9-10,14H2,1-2H3;1H

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分类

{SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Bioactive Small Molecules for Epigenetic Research, Celgene, Cell Biology, Cell Signaling and Neuroscience, DNA Methyltransferase Inhibitors, Epigenetics, Ion Channels, Molecular Biology, Monovalent Ion Channels, Non-nucleoside analog inhibitors, Other Sodium Channel Modulators, P, Sodium Channel Modulators, Voltage-gated Ion Channels
{SNA} Analytical Standards, EP Standards, EP Standards P - R, Pharmacopeia & Metrological Insti
{SNA} Additional Standards, Analytical Standards, Anesthetics Standards, Antibiotics Standards, Chemical Structure,
{SNA} Analytical Standards,

产品应用

A sodium channel blocker and DNA methylation inhibitor

安全信息

Safety Statements

S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S20 When using do not eat or drink 使用时，不得进食，饮水；
S36 Wear suitable protective clothing 穿戴适当的防护服；

Packing GroupIII

UN Number 2811

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R25 Toxic if swallowed 吞咽有毒
R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应

Storage condition 充氩保存 Air Sensitive

RTECSDG2275000

GHS Symbol

Precautionary statements

P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P301+P310+P330
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P501 Dispose of contents/container to..… 处理内容物/容器.....
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P305+P351+P338
P301+P310
P405 Store locked up. 上锁保管。
P301+P310+
P305+P351+P338+P337+P313
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P302+P352+P332+P313+P362+P364

Hazard statements

H317 May cause an allergic skin reaction 可能导致皮肤过敏
H301 Toxic if swallowed 吞食有毒

WGK Germany3

Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Signal word Danger

Hazard Codes T 6.1

Hazard Class6.1

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 192 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   ANTCAO Antibiotics and Chemotherapy (Washington, DC).  (Washington, DC)
   V.1-12, 1951-62.  For publisher information, see CLMEA3.
   Volume(issue)/page/year: 4,633,1954

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intracerebral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 11 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 9,137,1959

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 175 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZENBAX Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie,
   Organische Chemie, Biochemie, Biophysik, Biologie.  (Tuebingen, Fed. Rep.
   Ger.)  V.2B-27B, 1947-1972.  For publisher information, see ZNCBDA.
   Volume(issue)/page/year: 6B,183,1951

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 9,332,1954

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其他信息

无臭，味微苦，随后有麻痹感。本品在水中易溶，略溶于乙醇，微溶于氯仿，不溶于乙醚。
Procaine HCl是一种钠离子通道的，NMDA受体以及乙酰胆碱受体抑制剂， IC50分别为60 μM， 0.296 mM何45.5 μM，也是一种，5-HT3抑制剂，KD为1.7 μM。