CAS 61-25-6 MFCD00012745-Papaverine Hydrochloride 盐酸罂粟碱(精神类药品，不能销售) TAO{mole}

Papaverine Hydrochloride 盐酸罂粟碱(精神类药品，不能销售)

CAS 61-25-6 MFCD00012745

化学结构图

SMILES:

化学属性

Mol. Formula	C20H21NO4· HCl
Mol. Weight	375.85
Melting Point	ca 220° dec.
TSCA	Yes

别名和识别编码

Chemical Name	Papaverine Hydrochloride
CAS Number	61-25-6
Alfabeta Name	DIMETHOXYBENZYLDIMETHOXYISOQUINOLINEHYDROCHLORIDE 13467()----,,
MDL Number	MFCD00012745
Synonym	Papaverine hydrochloride Papaverine monohydrochloride Papanerin-HCl Artegodan 6,7,3',4'-Tetramethoxy-1-benzylisoquinoline hydrochloride Pavakey Dynovas 1-(3,4-Dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride 1-(3,4-二甲氧基苄基)-6,7-二甲氧基异喹啉盐酸盐, 99% Isoquinoline, 6,7-dimethoxy-1-veratryl-, hydrochloride Pavatest Therapav NCI-C56359 Dispamil Pavagrant Dipav Vasal 1-(3,4-Dimethoxybenzyl)-6,7-dimethoxyisoquinoline 6,7-Dimethoxy-1-veratrylisoquinoline hydrochloride Pameion Spasmo-nit Pavased Chlorhydrate de papaverine Cardoverina Lapav Cerespan Optenyl Vasospan Cepaverin Pavabid Papavarine chlorhydrate
Beilstein Registry Number	3921435
EC Number	200-502-1
Merck Number	14,7019
PubChem Substance ID	24278152
Chemical Name Translation	盐酸罂粟碱(精神类药品，不能销售)
InChIKey	XQYZDYMELSJDRZ-UHFFFAOYSA-N
Wiswesser Line Notation	T66 CNJ B1R CO1 DO1& HO1 IO1 &GH
LabNetwork Molecule ID	LN00156799

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分类

{SNA} Additional Standards, Alphabetical Index of Phytochemical Standards, Analytical Standards, Chromatography, N - R, Papaver, Pharmaceutical Secondary Standards, Pharmaceutical Standards, Pharmacopeia & Metrological Institutes Standards, Phytochemical Standards, Phytochemical Standards by Plant Genus, Secondary Pharmaceutical Standards, 分析/色谱
{SNA} Bioactive Small Molecule Alphabetical Index, Cyclic Nucleotide Metabolism, G Proteins and Cyclic Nucleotides, P-PH, Phosphodiesterase Inhibitors, Therapy Adjuncts, 抗肿瘤药物, 生物活性小分子, 癌症研究, 细胞信号转导和神经科学, 细胞生物学
{SNA} Analytical Standards,

安全信息

Warnings IRRITANT

GHS Symbol

WGK Germany1

Hazard statements

H302 Harmful if swallowed 吞食有害

Signal word Warning

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

RTECSNW8575000

Safety Statements

S36 Wear suitable protective clothing 穿戴适当的防护服；
S22 Do not breathe dust 不要吸入粉尘；

Risk Statements

R22 Harmful if swallowed 吞咽有害

Storage condition Light Sensitive

Hazard Codes Xn

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 68800 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 39,1109,1989

TYPE OF TEST            : LD50 - Lethal do

TYPE OF TEST            : TDLo - Lowest publi

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 14400 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 39,1109,1989

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 66 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4405627

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 123,264,1960

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Fibroblast
DOSE/DURATION           : 125 mg/L
REFERENCE :
   ESKHA5 Eisei Shikenjo Hokoku.  Bulletin of the Institute of Hygienic
   Sciences.  (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,
   Setagaya-ku, Tokyo 158, Japan)  V.1-    1886-  Volume(issue)/page/year:
   (96),55,1978

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 100 ug/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 240,267,1990

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 340 mg/L
REFERENCE :
   GMCRDC Gann Monograph on Cancer Research.  (Plenum Pub. Corp., 233 Spring
   St., New York, NY 10013) No. 11-    1971-  Volume(issue)/page/year:
   27,95,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 140 mg/kg
SEX/DURATION            : female 9 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
   DGDFA5 Development, Growth & Differentiation.  (Japan Pub. Trading Co.
   (USA), 1255 Howard St., San Francisco, CA 94103)  V.11-    1969-
   Volume(issue)/page/year: 22,61,1980