Hoechst 33258 Trihydrochloride 4-(5-[5-(4-甲基-1-哌嗪基)-2H-苯并咪唑-2-亚基]-5H-苯并咪唑-2-基)苯酚三盐酸盐

CAS 23491-45-4 MFCD00012679

化学结构图

23491-45-4
SMILES: Cl.Cl.Cl.CN1CCN(CC1)C1=CC2N=C(NC=2C=C1)C1=CC2N=C(NC=2C=C1)C1C=CC(O)=CC=1

化学属性

Mol. FormulaC25H27Cl3N6O
Mol. Weight534
Melting Point314 ºC
Solubility可溶

别名和识别编码

Chemical NameHoechst 33258 Trihydrochloride
Synonym Hoechst Dye 33258 Bisbenzimide Hoechst 33258 HOE 33058 NSC334072 甲嗪双苯咪酚 三盐酸盐 H 33258 赫斯特荧光染料 33258 溶液 BXI-72 Hoechst 33258 溶液 烟酸己可碱 三盐酸盐 Bisbenzimidazole trihydrochloride Bisbenzimide H 33258 NSC-322921 赫斯特荧光染料 33258 33258 Hoechst BBIH Phenol, 4-(5-(4-methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)-, Hoechst Stain solution Bisbenzimide; p-(5-(5-(4-Methyl-1-piperazinyl)-1H-2-benzimidazolyl)-1H-2-benzimidazolyl)phenol trihydrochloride BBIH BXI-72 HOE 33258 Hoechst 33258 NSC334072 烟酸己可碱 三盐酸盐 甲嗪双苯咪酚 三盐酸盐 HOE 33258
CAS Number23491-45-4
PubChem Substance ID172089156
EC Number245-690-6
Beilstein Registry Number4088183
MDL NumberMFCD00012679
Chemical Name Translation4-(5-[5-(4-甲基-1-哌嗪基)-2H-苯并咪唑-2-亚基]-5H-苯并咪唑-2-基)苯酚三盐酸盐
Reaxys-RN4088183
Wiswesser Line NotationT56 BM DNJ CR DQ& G- CT56 BM DNJ G- AT6N DNTJ D1 &GH3
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分类

  • {SNA} Alphabetical, Apoptosis Detection, Apoptosis and Cell Cycle, B, Bioactive Small Molecule Alphabetical Index, Fluorescent Stains, Mycoplasma Detection, Nucleic Acid Stains, Reagents, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞培养, 细胞生物学, 荧光探针，标记，粒子和染色剂, 试剂和添加剂
  • In Vivo/In Vitro Tracking of Stem
  • {SNA} Alphabetical, Detection, Fluorescent Stains, Nucleic Acid Stains, Nucleic Acid Stains For Flow Cytometry, Nucleic Acid Stains For Microscopy, Wavelength Index, 发光化合物及其检测,

相关文献及参考

  • {
  • Merck 14 ,10367

安全信息

GHS Symbol
WGK Germany3
Hazard Codes Xn
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H302 Harmful if swallowed 吞食有害
  • H319 Causes serious eye irritation 严重刺激眼睛
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
RTECSSM1140500
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P302+P352+P332+P313+P362+P364
  • P332+P313
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P302+P350
  • P337+P313
Signal word Warning
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
  • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
Risk Statements
  • R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
Storage condition <0°C 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 36900 ug/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - dyspnea
   Skin and Appendages - hair
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB84-171206

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 32200 ug/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - dyspnea
   Skin and Appendages - hair
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB84-171206

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 10 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 89,95,1981

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Mammal - species unspecified Lymphocyte
DOSE/DURATION           : 1600 nmol/L
REFERENCE :
   CHROAU Chromosoma.  (Springer-Verlag New York, Inc., Service Center, 44
   Hartz Way, Secaucus, NJ 07094)  V.1-    1939-  Volume(issue)/page/year:
   52,297,1975

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - rat Fibroblast
DOSE/DURATION           : 1 mg/L
REFERENCE :
   ZZACAG Zeitschrift fuer Zellforschung und Mikroskopische Anatomie. (Berlin,
   Fed. Rep. Ger.) V.1-147, 1924-73.  For publisher information, see CTSRCS. 
   Volume(issue)/page/year: 104,127,1970

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 2 umol/L
REFERENCE :
   CHROAU Chromosoma.  (Springer-Verlag New York, Inc., Service Center, 44
   Hartz Way, Secaucus, NJ 07094)  V.1-    1939-  Volume(issue)/page/year:
   52,297,1975

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - mouse Fibroblast
DOSE/DURATION           : 1 mg/L
REFERENCE :
   ZZACAG Zeitschrift fuer Zellforschung und Mikroskopische Anatomie. (Berlin,
   Fed. Rep. Ger.) V.1-147, 1924-73.  For publisher information, see CTSRCS. 
   Volume(issue)/page/year: 104,127,1970

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 10 umol/L
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 258,121

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Fluorescent Probes, Labels, Particles and Stains - Biochemicals and Reagents
  4. Detection - Fluorescent Probes, Labels, Particles and Stains
  1. Life Science 生命科学
  2. Hematology and Histology 血液学和组织学
  3. Stains and Dyes - Hematology and Histology
  4. Stains &amp; Dyes, A to Z - Stains and Dyes
  5. B - Stains &amp; Dyes, A to Z
  1. Life Science 生命科学
  2. Cell Culture 细胞培养
  3. Reagents and Supplements - Cell Culture
  4. Assays and Reagents for Measuring Cytotoxicity, Proliferation and Viability - Reagents and Supplements
  5. Stains, Dyes and Indicators - Assays and Reagents for Measuring Cytotoxicity, Proliferation and Viability
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Benzimidazoles 苯并咪唑
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Fluorescent Probes, Labels, Particles and Stains - Biochemicals and Reagents
  4. Fluorescent Stains - Fluorescent Probes, Labels, Particles and Stains
  5. Nucleic Acid Stains - Fluorescent Stains
  6. Alphabetical - Nucleic Acid Stains
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Apoptosis and Cell Cycle - Cell Signaling and Neuroscience
  5. Apoptosis Detection - Apoptosis and Cell Cycle
  6. Reagents - Apoptosis Detection
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Stem Cell Biology - Cell Biology
  4. General Stem Cell Biology - Stem Cell Biology
  5. Stem Cell Characterization - General Stem Cell Biology
  6. General Stains/Dyes for Stem Cell Biology - Stem Cell Characterization
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Fluorescent Probes, Labels, Particles and Stains
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Culture
  4. Miscellaneous Reagents and Supplements
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Luminescent Compounds/Detection
  4. Fluorescent Probes, Labels, Particles and Stains
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Reagents and Supplements
  4. Miscellaneous Reagents and Supplements
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Culture
  4. Reagents and Supplements
  5. Miscellaneous Reagents and Supplements
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Apoptosis and Cell Cycle
  5. Apoptosis Detection
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Fluorescent Probes, Labels, Particles and Stains
  4. Fluorescent Stains
  5. Nucleic Acid Stains
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Molecular Biology
  4. Reagents for Antibody Detection
  5. Antibody Modification
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Peptides and Proteins
  5. Apoptosis and Cell Cycle Proteins
  6. Apoptosis Detection
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Fluorescent Probes, Labels, Particles and Stains
  4. Fluorescent Stains
  5. Nucleic Acid Stains
  6. Alphabetical
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Fluorescent Probes, Labels, Particles and Stains
  4. Fluorescent Stains
  5. Nucleic Acid Stains
  6. Nucleic Acid Stains For Flow Cytometry
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Luminescent Compounds/Detection
  4. Fluorescent Probes, Labels, Particles and Stains
  5. Fluorescent Stains
  6. Nucleic Acid Stains
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Proteins and Derivatives
  4. Proteins for Cell Biology
  5. Apoptosis and Cell Cycle Proteins
  6. Apoptosis Detection
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Luminescent Compounds/Detection
  4. Fluorescent Probes, Labels, Particles and Stains
  5. Fluorescent Stains
  6. Nucleic Acid Stains
  7. Alphabetical
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Luminescent Compounds/Detection
  4. Fluorescent Probes, Labels, Particles and Stains
  5. Fluorescent Stains
  6. Nucleic Acid Stains
  7. Nucleic Acid Stains For Flow Cytometry

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