3,6-Diamino-9-(2-(Methoxycarbonyl)Phenyl)Xanthylium Chloride 3,6-二氨基-9-(2-(甲氧基羰基)苯基)氧杂蒽氯化物
CAS 62669-70-9 MFCD00012664
化学结构图
SMILES: Cl.COC(=O)C1=CC=CC=C1C1C2C=CC(N)=CC=2OC2=CC(=N)C=CC=12
化学属性
| Mol. Formula | C21H17ClN2O3 |
|---|---|
| Mol. Weight | 381 |
| Density | 1.422 |
| Melting Point | 235°C |
| Solubility | Soluble in ethanol (20 mg/ml), DMSO, methanol, and water (partly miscible). |
别名和识别编码
| Chemical Name | 3,6-Diamino-9-(2-(Methoxycarbonyl)Phenyl)Xanthylium Chloride |
|---|---|
| Synonym | 2-(6-Amino-3-imino-3H-xanthen-9-yl)benzoic acid methyl ester 罗丹明123 |
| Beilstein Registry Number | 6030951 |
| PubChem Substance ID | 57652966 |
| CAS Number | 62669-70-9 |
| EC Number | 263-687-8 |
| MDL Number | MFCD00012664 |
| Chemical Name Translation | 3,6-二氨基-9-(2-(甲氧基羰基)苯基)氧杂蒽氯化物 |
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分类
- Alphabetical, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology,
- {SA} Alphabetical, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Fluorescent Indicators and Probes, Fluorescent Probes, Labels, Particles and Stains, Lipophilic and Membrane Probes, Lipophilic and Membrane Probes for Flow Cytometry,
产品应用
- Useful as a laser dye and to have selective cell growth effects. Mitochondrial specific fluorescent dye and substrate for P-glycoprotein.
相关文献及参考
- 1. L. Benel et al. Bas. Appl. Histochem. 33 , 71, (1989)
- Wuchter, C., et al. Haematologica 85 , 711-721, (2000) 摘要
- Minderman, H., et al., DiOC2(3) is not a substrate for multidrug resistance protein (MRP)-mediated drug efflux. Cytometry 25 , 14-20, (1996)
- Merck 14 ,10356
安全信息
GHS Symbol
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE : 60 mg/kg SEX/DURATION : female 7-10 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - other effects to embryo REFERENCE : TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year: 9,29,1989
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE : 60 mg/kg SEX/DURATION : female 7-10 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 40,143,1989
其他信息
- Rhodamine 123 is a cationic dye that emits a green fluorescence. Research observations indicate that Rhodamine 123 can be used to probe the electrochemical gradient in mitochondria, in flow cytometry to detect the activity of P-glycoprotein efflux, and as a compound for P-GP mediating transport. Studies report that Rhodamine 123 can decrease the clonal growth of carcinoma cells in vitro, and that it can associate with placental P-gp. Rhodamine 123 is a substrate of Mdr (P-glycoprotein). Rhodamine 123 is a substrate of MRP1.
