CAS 69-09-0 MFCD00012654-Chlorpromazine Hydrochloride,Chlorpromazine Hcl 盐酸氯丙嗪 TAO{mole}

Chlorpromazine Hydrochloride,Chlorpromazine Hcl 盐酸氯丙嗪

CAS 69-09-0 MFCD00012654

化学结构图

SMILES: CN(C)CCCN1c2ccccc2Sc2ccc(Cl)cc21.Cl

化学属性

Mol. Formula	C17H20Cl2N2S
Mol. Weight	355
Melting Point	195-199
Solubility	DMSO 71 mg/mL Water 71 mg/mL Ethanol 71 mg/mL
TSCA	Yes
Appearance	白色或乳白色结晶性粉末。熔点179-180℃（194-196℃）。易溶于水、乙醇、氯仿，不溶于乙醚、苯。有引湿性，5%水溶液加pH值为4-5。微臭，味极苦。本品易氧化，在空气或日光中渐变为红棕色。
Stability	对光及湿度敏感

别名和识别编码

Chemical Name	Chlorpromazine Hydrochloride,Chlorpromazine Hcl
CAS Number	69-09-0
Alfabeta Name	CHLOROPHENOTHIAZINYLPROPYLDIMETHYLAMINEHYDROCHLORIDE H321010[]()-------
MDL Number	MFCD00012654
Synonym	Klorproman 2-Chloro-10-[3-(dimethylamino)-1-propyl]phenothiazine hydrochloride 盐酸氯丙嗪 Prom 2-Chloro-10-(3-DimethyAminopropyl)PhenothiazineHydrochloride (3-(2-chloro-phenothiazin-10-yl)-propyl)-dimethyl-amine hydrochloride Plegomazin 2-CHLORO-10-[3'-(DIMETHYLAMINO)PROPYL]PHENOTHIAZINE, HCL 2-氯-10-(3-二甲氨基丙基)吩噻嗪盐酸盐 10-(3-dimethylaminopropyl)-2-chlorophenothiazine monohydrochloride {Chemica Chlor-PZ Fenactil monohydrochloride KLORPROMEX aminazin hydrochloride Phenothiazine, 2-chloro-10-[3-(dimethylamino)propyl]-, monohydrochloride 2-Chloro-10-[3-(dimethylamino)propyl]phenothiazine Hydrochloride 2-氯-10-(3-二甲氨基丙基)吩噻嗪盐酸盐 CPZ {Chemi {Ch
Beilstein Registry Number	3779989
EC Number	200-701-3
PubChem Substance ID	6240
Merck Number	2185
Reaxys-RN	3779989
Chemical Name Translation	盐酸氯丙嗪
Wiswesser Line Notation	T C666 BN ISJ B3N1&1 EG &GH
LabNetwork Molecule ID	LN00159540
InChI	InChI=1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H

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产品应用

在血红蛋白和过氧化物酶的微量测定中替代联苯胺、邻联?茴香胺和邻联甲苯胺。

安全信息

Warnings IRRITANT

GHS Symbol

WGK Germany3

Precautionary statements

P301+P310
P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
P284 Wear respiratory protection.? 佩戴呼吸保护装置。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P301+P310+P330
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P304+P340+P310
P501 Dispose of contents/container to..… 处理内容物/容器.....
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P405 Store locked up. 上锁保管。

Hazard statements

H301 Toxic if swallowed 吞食有毒
H330 Fatal if inhaled 吸入致命

RTECSSO1750000

Signal word

Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

Safety Statements

S9 Keep container in a well-ventilated place 保持容器在通风良好的场所；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；

Packing GroupI

UN Number UN 2811 6.1/PG 1

Risk Statements

Hazard Codes T+

Hazard Class6.1

Storage condition 室温保存储存温度-20°C 储存温度 -20°C

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 40 mg/m3/2H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
   Prague, Czechoslovakia, Avicenum, 1986  Volume(issue)/page/year: -,1106,1986

TYPE OF TEST            : LC50 -

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 62 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSYPAG Psychopharmacologia (Berlin).  (Berlin, Ger.)  V.1-46, 1959-76.  For
   publisher information, see PSCHDL.  Volume(issue)/page/year: 12,142,1968

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : >30 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - muscle weakness
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 122,129,1959

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 6 mg/kg
TOXIC EFFECTS :
   Behavioral - anorexia (human)
   Gastrointestinal - other changes
REFERENCE :
   PGMJAO Postgraduate Medical Journal.  (Blackwell Scientific Pub. Ltd., POB
   88, Oxford, UK) V.1-    1925-  Volume(issue)/page/year: 60,564,1984

TYPE OF TEST

{hazard_co

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 5 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 208,33,1988

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 5 mg/L
REFERENCE :
   GENRA8 Genetical Research.  (Cambridge Univ. Press, 32 E. 57th St., New
   York, NY 10022) V.1-    1960-  Volume(issue)/page/year: 30,13,1977

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 48 mg/L
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   26,1205,1977

TYPE OF TEST            : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 25 mg/kg
REFERENCE :
   DCTODJ Drug and Chemical Toxicology.  (Marcel Dekker, 270 Madison Ave., New
   York, NY 10016) V.1-    1977/78-  Volume(issue)/page/year: 9,41,1986

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 48 mg/L
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   26,1205,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 50 mg/kg
SEX/DURATION            : female 12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 18,167,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 50 mg/kg
SEX/DURATION            : female 7-16 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   21,230,1972

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 12 mg/kg
SEX/DURATION            : female 12-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
   BRREAP Brain Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1966-  Volume(issue)/page/year: 21,460,1970

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 125 mg/kg
SEX/DURATION            : male 5 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (B

其他信息

类别:有毒物质
方法一:由2-氯吩噻嗪[92-39-7]缩合、成盐而得。1.缩合在反应锅中加入2-氯吩噻嗪和甲苯，再加入氢氧化钠，搅拌加热回流，脱除水分，在110℃滴加1-氯-3-二甲胺基丙烷的甲苯溶液，将反应物减压回收甲苯，即得氯丙嗪，C17H19CIN2S，[50-53-3]。2.成盐将氯丙嗪和异丙醇搅拌加热至40℃，通入干燥的氯化氢至pH4-5，即成盐得到盐酸氯丙嗪。
氯丙嗪盐酸盐
毒性分级:高毒
MOL 文件:69-09-0.mol
上游原料:二甲胺 --> 1-溴-3-氯丙烷 --> 2-氯吩噻嗪
可燃性危险特性:可燃, 燃烧时分解有毒氮氧化物, 氯化物, 硫氧化物气体
急性毒性:口服- 大鼠 LD50 145 毫克/ 公斤; 口服- 小鼠 LD50: 135 毫克/公斤
用途一:本品是吩噻类药物中的代表性药物。对中枢神经系统，小剂量有安定作用，大剂量连续使用有抗精神病作用，本品抑制丘脑下体温调节中枢，使体温随环境温度升降，配合其他药物，使体温降至正常体温之下，代谢降低，称人工冬眠。主要用于抗精神病、加强催眠剂、麻醉剂、镇痛剂及抗惊厥剂的作用。又可用于对呕吐和顽固性呃逆的镇吐及引起人工冬眠等。
储运特性:库房低温, 通风, 干燥; 与食品原料分开存放
灭火剂:水, 二氧化碳, 干粉, 砂土
F:3-10-21
MSDS 信息:Largactil(69-09-0).msds
海关编码:29173980
Sigma Aldrich:69-09-0(sigmaaldrich)