Promethazine Hydrochloride 10-(2-二甲基氨基-1-丙基)吩噻嗪盐酸盐
CAS 58-33-3 MFCD00012652
化学结构图
SMILES: CC(CN1c2ccccc2Sc2ccccc21)N(C)C.Cl
化学属性
| Mol. Formula | C17H20N2S.HCl |
|---|---|
| Mol. Weight | 321 |
| Melting Point | 224-228 |
别名和识别编码
| Chemical Name | Promethazine Hydrochloride |
|---|---|
| CAS Number | 58-33-3 |
| Synonym | (2-Dimethylamino-2-methyl)ethyl-N-dibenzoparathiazine Hydrochloride 10-(2-(Dimethylamino)propyl)phenothiazine monohydrochloride 10-(2-(dimethylamino)propyl)-phenothiazinmonohydrochlo 10-(2-Dimethylamino-1-propyl)phenothiazine hydrochloride 10-(2-Dimethylaminopropyl)phenothiazine hydrochloride 10-(2-二甲基氨基-1-丙基)吩噻嗪盐酸盐 10-(3-Dimethylaminoisopropyl)phenothiazine hydrochloride 10-[2-(Dimethylamino)propyl]phenothiazine hydrochloride Atosil Fellozine Ganphen HL 8700 Kinetosin N,N,alp N-(2'-Dimethylamino-2'-methyl)ethylphenothiazine hydrochloride PHENERGAN Pipolfen atosil diprazin n,n,alpha-trimethyl-10h-phenothiazine-10-ethanaminmonohydrochloride 普鲁米近 盐酸盐 非那根 |
| MDL Number | MFCD00012652 |
| PubChem Substance ID | 160871508 |
| Beilstein Registry Number | 4166397 |
| EC Number | 200-375-2 |
| Chemical Name Translation | 10-(2-二甲基氨基-1-丙基)吩噻嗪盐酸盐 |
| Merck Number | 7786 |
| Reaxys-RN | 4166397 |
| Wiswesser Line Notation | T C666 BN ISJ B1Y1&N1&1 &GH |
| LabNetwork Molecule ID | LN01303614 |
| InChI | InChI=1S/C17H20N2S.ClH/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19;/h4-11,13H,12H2,1-3H3;1H |
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资金保障
专业采购外包团队在线服务
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分类
- {SNA} Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Histaminergics, Histaminergics - Antagonists, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitters, PI-PZ, Wyeth, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 蛋白质及衍生物
- {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Antibiotics, Chemical Structure, Chromatography, Clinical Standards,
- {SNA} Addit
- {SNA} Addition
产品应用
- Antihistaminic, antiemetic, CNS depressant.
相关文献及参考
- [2]. Fiorella D, et al. The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of hallucinogenic drugs. I: Antagonist correlation analysis. Psychopharmacology (Berl). 1995 Oct;121(3):347-56.
- [3]. Seeman P, et al. Dopamine D2 receptor binding sites for agonists. A tetrahedral model. Mol Pharmacol. 1985 Nov;28(5):391-9.
- [4]. Burt DR, et al. Antischizophrenic drugs: chronic treatment elevates dopamine receptor binding in brain. Science. 1977 Apr 15;196(4287):326-8.
- Edge, W., et al.: J. Pharm. Pharmacol., 5, 279 (1953),
- Huang, et al.: J. Pharm. Sci., 59, 772 (1970),
- [1]. Strenkoski-Nix LC, et al. Pharmacokinetics of promethazine hydrochloride after administration of rectal suppositories and oral syrup to healthy
- [1]. Strenkoski-Nix LC, et al. Pharmacokinetics of promethazine hydrochloride after administration of rectal suppositories and oral syrup to healthy subjects. Am J Health Syst Pharm. 2000 Aug 15;57(16):1499-505.
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P273 Avoid release to the environment. 避免释放到环境中。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P312+P330
- P302+P352+
- P302+P352+P332+P313+P362+P364
- P305+P351+P338
- P305+P351+P338+P337+P313
- P332+P313
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
- P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H302 Harmful if swallowed 吞食有害
- H302+H332
- H315 Causes skin irritation 会刺激皮肤
- H317 May cause an allergic skin reaction 可能导致皮肤过敏
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
- S22 Do not breathe dust 不要吸入粉尘；
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
- S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
- R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害
- R22 Harmful if swallowed 吞咽有害
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
- R51/53
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 255 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 135,364,1962
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 108,340,1953
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - child DOSE/DURATION : 20 mg/kg TOXIC EFFECTS : Behavioral - excitement Behavioral - changes in motor activity (specific assay) Behavioral - stiffness REFERENCE : LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 1,368,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 240 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 22,375,1980
TYPE OF TEST : LD
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 240 mg/kg SEX/DURATION : female 5-16 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - other measures of fertility REFERENCE : RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 7,701,1974
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 60 mg/kg SEX/DURATION : female 5-16 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 7,701,1974
其他信息
- 上游原料:吩噻嗪
- 用途一:适用于各种过敏性疾病和孕期呕吐。
- MSDS 信息:10-(2-Dimethylamino-1-propyl)phenothiazine hydrochloride(58-33-3).msds
- MOL 文件:58-33-3.mol
- Sigma Aldrich:58-33-3(sigmaaldrich)
- 图谱信息:盐酸异丙嗪(58-33-3)红外图谱(IR1) 盐酸异丙嗪(58-33-3)核磁图( 1 HNMR) 盐酸异丙嗪(58-33-3)质谱(MS) 盐酸异丙嗪(58-33-3)红外图谱(IR2) 盐酸异丙嗪(58-33-3)核磁图( 13 CNMR)
