CAS 147-24-0 MFCD00012479-Diphenhydramine hydrochloride 苯海拉明盐酸盐 TAO{mole}

Diphenhydramine hydrochloride 苯海拉明盐酸盐

CAS 147-24-0 MFCD00012479

化学结构图

SMILES: CN(C)CCOC(c1ccccc1)c1ccccc1.Cl

化学属性

Mol. Formula	C17H21NO.HCl
Mol. Weight	292
Density	1.422
Melting Point	168.0 to 172.0 deg-C
TSCA	No
Solubility	Soluble in water (1000 mg/ml), DMSO (58 mg/ml at 25 °C), DMF (~10 mg/ml), methanol, and ethanol (500 mg/ml).
Appearance	水溶性1000 g/L，熔点168-169℃

别名和识别编码

Chemical Name	Diphenhydramine hydrochloride
Synonym	{uni_hamburg} Dimethylamine benzhydr 2-二苯甲氧基-N,N-二甲基乙胺盐酸盐 N,N-二甲基-2-(二苯甲氧基)乙胺盐酸盐 2-二苯甲氧基-N,N-二甲基乙胺盐酸盐 Cathejell 2-DIPHENYLMETHOXY-N,N-DIM Fenylhist Ethanamine, 2-(diphenylmethoxy)-N,N-dimethyl-, hydrochloride Resmin alpha-Hydroxydiphenylmethane-beta-dimethylaminoethyl ether hydrochloride Allergan Ethylamine, 2-(diphenylmethoxy)-N,N-dimethyl-, hydrochlo BENA Prodryl Felben 2-diphenylmethoxy-N,N-dimethylethanamine hydrochl 2-(diphenylmethoxy)-n,n-dimethyl-ethylaminhydrochloride 2-(Benzhydryloxy)-N,N-dimethyle 苯海拉明盐酸盐 Benzhydramine hydrochloride 2-(benzhydryloxy)-n,n-dimethylethylamine hydrochloride β-Dimethylaminoethyl benzhydryl ether hydrochloride N-(2-DIPHENY Ambenyl Carphenamine Actifed {uni_hamburg Benzantin hydrochlorid Benzhydrol β-dimethylaminoethyl ether hydrochloride sk-Diphenhydramine LABOTEST-BB LT00248571 BENZHYDRAMINE HYDROCHLORIDE DIPHENHYDRAMINE HYDROCHLORIDE Restamin Bena 2-Diphenylmethoxy-N,N-dimethylethylamine hydrochloride Ethylamine, N,N-dimethyl-2-(diphenylmethoxy)-, hydrochloride Vena Diphenhydramine hydrochloride {uni_ha Benadryl Bendylate {uni_ Denydryl {un Difenhydramine hydrochloride 二甲氨基乙醇二苯 Diphenylhydramine hydrochloride Diphamine N-(2-DIPHENYLMETHOXYETHYL)-N,N-DIMETHYLAMIDE
CAS Number	147-24-0
EC Number	205-687-2
Beilstein Registry Number	2384789
MDL Number	MFCD00012479
PubChem Substance ID	87567103
Chemical Name Translation	苯海拉明盐酸盐
Reaxys-RN	3918132
Merck Number	3309
Wiswesser Line Notation	1N1&2OYR&R &GH
LabNetwork Molecule ID	LN00216146

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分类

{SNA} Additional Stan
{SNA} Analytical Standards, Chromatography, EP Standards, EP Standards C - D, Pharmaceutical Standards, Pharmacopeia Standards, 分析/色谱
{SNA} Analytical Standards,
{SNA} 1694 Pharmaceuticals & Personal Care Products, Additional Standards, Analytical Standards, Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, DIG-DY, EPA, Histaminergics, Method and Regulation Specific, Neats, Neuroscience, Neurotransmission, Neurotransmitters, Pfizer Compounds, 分析/色谱, 生物活性小分子,

产品应用

A histamine H1-receptor antagonist.

安全信息

Signal word Warning

GHS Symbol

WGK Germany3

Safety Statements

S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
S36 Wear suitable protective clothing 穿戴适当的防护服；

Risk Statements

R22 Harmful if swallowed 吞咽有害
R25 Toxic if swallowed 吞咽有毒
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
R63 Possible risk of harm to the unborn child 可能危害未出生婴儿

Precautionary statements

P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P301+P312
P301+P312+P330
P501 Dispose of contents/container to..… 处理内容物/容器.....

Packing GroupIII

UN Number UN2811 2811

Storage condition Light Sensitive 储存温度-20°C

Hazard statements

H302 Harmful if swallowed 吞食有害

RTECSKR7000000

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Hazard Codes Xn

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 27037 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Brain and Coverings - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-355,1989

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 60 mg/kg/6H-I
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Behavioral - halluci

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   FEPRA7 Federation Proceedings, Federation of American Societies for
   Experimental Biology. (Bethesda, MD)  V.1-46, 1942-87.
   Volume(issue)/page/year: 4,150,1945

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 201 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKKZAJ Yakugaku Zasshi.  Journal of Pharmacy.  (Nippon Yakugakkai, 2-12-15
   Shibuya, Shibuya-ku, Tokyo 150, Japan)  No.1-    1881-
   Volume(issue)/page/year: 81,261,1961

TYPE OF TEST            : LD50 - Lethal do

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - muscle contraction or spasticity
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 113,72,1955

TYPE OF TEST            : LD50 - Lethal

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 100 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   13,60,1989

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 100 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 368,59,1996

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 320 mg/kg
SEX/DURATION            : female 11-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB83-148684

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 50 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   JPMSAE Journal of Pharmaceutical Sciences.  (American Pharmaceutical Assoc.,
   2215 Constitution Ave., NW, Washington, DC 20037)  V.50-    1961-
   Volume(issue)/page/year: 60,420,1971

TYPE OF TES

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 100 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   JPMSAE Journal of Pharmaceutical Sciences.  (American Pharmaceutical Assoc.,
   2215 Constitution Ave., NW, Washington, DC 20037)  V.50-    1961-
   Volume(issue)/page/year: 60,420,1971

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1600 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :

其他信息

储运特性:通风低温干燥; 与库房食品原料分开存放
Sigma Aldrich:147-24-0(sigmaaldrich)
TCI Shanghai:盐酸苯海拉明 Diphenhydramine Hydrochloride,>;98.0%(LC)(T)(147-24-0)
毒性分级:高毒
Diphenhydramine HCl 是组胺H1拮抗剂，可用于止吐止咳，治疗皮肤病和皮肤瘙痒，过敏反应，用作安眠药，治疗帕金森，作为感冒制剂一种组分
类别:有毒物品
MOL 文件:147-24-0.mol
可燃性危险特性:燃烧产生有毒氮氧化物和氯化氢烟雾;药物副作用:心律不齐,血压上升,共济失调
盐酸苯海拉明价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 D0423 盐酸苯海拉明 Diphenhydramine Hydrochloride 500G 1940元 2014/06/02 D0423 盐酸苯海拉明 Diphenhydramine Hydrochloride 25G 254元 2010/06/21 350851000 盐酸苯海拉明 Diphenhydramine hydrochloride 99% 100 GR 730元
MSDS 信息:N-(2-Diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride(147-24-0).msds
图谱信息:盐酸苯海拉明(147-24-0)质谱(MS) 盐酸苯海拉明(147-24-0)Raman光谱盐酸苯海拉明(147-24-0)红外图谱(IR1) 盐酸苯海拉明(147-24-0)红外图谱(IR2) 盐酸苯海拉明(147-24-0)核磁图( 13 CNMR)
苯海拉明盐酸盐
Alfa Aesar:Diphenhydramine hydrochloride, 99%(147-24-0)
急性毒性:口服-大鼠 LD50: 500 毫克/公斤; 口服-小鼠 LD50: 114 毫克/公斤
灭火剂:干粉,泡沫,沙土,二氧化碳, 雾状水
Acros Organics:盐酸苯海拉明 Diphenhydramine hydrochloride, 99%(147-24-0)