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分类

• {uni_hamburg}
• {SNA} Chemical Synthesis, Deprotecting Reagents, Fluoride Sources, Fluorination, Fluorination Reagents, Protection and Derivatization, Synthetic Reagents

产品应用

• Convenient form of anhydrous HF, stable up to 50°C. Has been used for the preparation of β-fluoroamines from amino alcohols and for the fluorination of acetylenes.
• Used together with hypervalent iodine(III) reagents for ipso-fluorination of para-substituted phenols providing cyclohexadienones. Employed for geminal fluorination of 2,2-diaryl-1,3-dithiolane?s.
• Reactant for preparation of:
• Epimers of shikimic acid with the features of fucosylated glycans via zinc-mediated reductive ring opening followed by a Barbier reaction
• Vaccinia H1-related (VHR) phosphatase inhibitor with a nonacidic phosphate-mimicking core structure
• Candidates for nucleic acid drugs
• ω-substituted gem-difluoroalkanes by oxidative desulfurization-difluorin?ation
• Reagent for:
• Halofluorination reactions

相关文献及参考

• The reagent is also widely applied to the cleavage of a variety of silyl protecting groups including TBDMS, TES, TBDPS and TIPS: Synthesis, 453 (1986); J. Am .Chem. Soc., 112, 7001 (1990); for further discussion see: P. Kocienski, Protecting Groups, Thieme, Stuttgart (1994).
• Short: EINECS
• Convenient form of anhydrous HF, showing increased reactivity in many reactions: J. Org. Chem., 44, 3872 (1979). Alkenes and alkynes undergo hydrofluorination; in the presence of NIS or NBS, iodo- or bromofluorination occurs: Synthesis, 779 (1973). Secondary and tertiary alcohols are converted to alkyl fluorides: Synthesis, 653 (1974). Diazotization of ɑ-amino acids in the presence of the reagent provides good yields of ɑ-fluoro acids: Synthesis, 654 (1974). Reaction with aryldiazonium salts or triazenes leads to aryl fluorides, providing a convenient alternative to the Balz-Schiemann reaction (see Tetrafluoroboric acid, L14037): J. Am. Chem. Soc., 97, 208 (1975); J. Chem. Soc., Chem. Commun., 914 (1979); Bull. Chem. Soc. Jpn., 63, 2058 (1990).
• In combination with nitrosonium tetrafluorborate, ketoximes are converted to gem-difluorides: Synlett, 425 (1994).
• For use in electrophilic electrochemical fluorination, see: J. Fluorine Chem., 83, 31 (1997).
• In combination with nitrosonium tetr
• Short: II/2

安全信息

其他信息

• Sigma Aldrich:62778-11-4(sigmaaldrich)
• F:3-10
• Alfa Aesar:氟化氢吡啶络合物,大约70%HF Hydrogen fluoride pyridine complex, ca 70% HF(62778-11-4)
• Hazard Note:Very Toxic/Corrosive/Keep Cold/Store in Nalgene
• MOL 文件:62778-11-4.mol
• 吡啶氢氟酸盐价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/05/25 L17117 氟化氢吡啶络合物, 大约 70% HF Hydrogen fluoride pyridine complex, ca 70% HF 25g 402元 2010/05/25 L17117 氟化氢吡啶络合物, 大约 70% HF Hydrogen fluoride pyridine complex, ca 70% HF 100g 799元