Neostigmine Bromide 溴化新斯的明

CAS 114-80-7 MFCD00011795

化学结构图

114-80-7
SMILES: CN(C)C(=O)Oc1cccc([N+](C)(C)C)c1.[Br-]

化学属性

Mol. FormulaC12 H19 N2 O2 . Br
Mol. Weight303.2
Melting Point175-177
Solubility1 G/ ML
TSCANo
Appearance powder

别名和识别编码

Chemical NameNeostigmine Bromide
CAS Number114-80-7
Synonym ######## (3-(dimethylcarbamoyloxy)phenyl)trimethyl-ammoniumethylsulfate (3-DIMETHYLCARBAMOYLOXY (3-DIMETHYLCARBAMOYLOXYPHENYL)TRIMETHYLAMMONIUM METHYL SULFATE (3-Dimethylcarbamoyloxyphenyl)trimethylammonium Bromide; (3-Hydroxyphenyl)trimethylammonium Bromide Dimethyl Carbamate (3-HYDROXYPHENYL)TRIMETHYLAMMONIUM BROMIDE DIMETHYL CARBAMATE (3-HYDROXYPHENYL)TRIMETHYLAMMONIUM METHYL SULFATE DIMETHYLCARBAMATE 3-(((dimethylamino)carbonyl)oxy)-n,n,n-trimethyl-benzenaminiumethylsulfat 3-(N,N-Dimethylcarbamoyloxy)-N,N,N,-trimethylanilinium bromide Prostigmine 3-(dimethylcarbamoxy)phenyltrimethylammoniummethylsulfate 3-[[(DIMETHYLAMINO)CARBONYL]OXY]-N,N,N-TRIMETHYLBENZAMINIUM BROMIDE 3-[[(DIMETHYLAMINO)CARBONYL]OXY]-N,N,N-TRIMETHYLBENZENAMINIUM BROMIDE Bromide, Neostigmine Methylsulfate, Neostigmine Neo
MDL NumberMFCD00011795
PubChem Substance ID8246
EC Number204-054-8
Merck Number6464
Reaxys-RN3640678
Beilstein Registry Number13(3)939
Chemical Name Translation溴化新斯的明
Wiswesser Line Notation1N1&VOR CK1&1&1 &E
LabNetwork Molecule IDLN00224249
InChIInChI=1S/C12H19N2O2.BrH/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5;/h6-9H,1-5H3;1H/q+1;/p-1
Canonical SMILESC[N+](C)(C)C1=CC=CC(OC(N(C)C)=O)=C1.[Br-]
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分类

  • Pharmaceuticals
  • {SNA} Acetylcholinesterase, Analytical and Industrial Enzymes, Bioactive Small Molecule Alphabetical Index, Cholinesterase Inhibitors, Cholinesterase and Organophosphate Detection Reagents, Enzyme Inhibitors, N, Neuroscience, Neurotransmission,
  • {SNA} Acetylcholinesterase, Analytical and Industrial Enzymes, Bioactive Small Molecule Alphabetical Index, Cholinesterase Inhibitors, Cholinesterase and Organophosphate Detection Reagents, Enzyme Inhibitors, N, Neuroscience, Neurotransmission, Neurotransmitter Metabolism, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底物
  • {SNA} Acetylcholinestera

产品应用

  • Cholinergic; miotic; antidote (curare).

相关文献及参考

  • Calvey, T.N., et al.: Br. J. Clin. Pharmacol., 7, 149 (1979),
  • Al-Badr, A.A., et al.: Anal. Profiles Drug Subs., 16, 403 (1987),

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H300 Fatal if swallowed 吞食致命
  • H301 Toxic if swallowed 吞食有毒
  • H310 Fatal in contact with skin 皮肤接触致命
  • H315 Causes skin irritation 会刺激皮肤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H330 Fatal if inhaled 吸入致命
  • H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
RTECSBR3150000
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛,皮肤或衣服。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P285 In case of inadequate ventilation wear respiratory protection. 在通风不足的情况下,戴呼吸防护。
  • P301+P310
  • P301+P310+P330
  • P302+P350
  • P302+P352
  • P302+P352+P332+P313+P362+P364
  • P304+P340
  • P304+P341
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P320 Specific treatment is urgent (see … on this label). 紧急具体治疗(见本标签上的)。
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P322 Specific measures (see …on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P333+P313
  • P337+P313
  • P342+P311
  • P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Hazard Codes 6.1 T+
Safety Statements
  • S20 When using do not eat or drink 使用时,不得进食,饮水;
  • S22 Do not breathe dust 不要吸入粉尘;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S27/28
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后,立即用大量…(由生产厂家指定)冲洗;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护;
  • S4 Keep away from living quarters 远离生活区;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
  • S9 Keep container in a well-ventilated place 保持容器在通风良好的场所;
Risk Statements
  • R26/27/28 Very toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有剧毒
  • R28 Very toxic if swallowed 吞咽极毒
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R42/43
Packing GroupII
UN Number 2811 UN 2811 6.1/PG 2
Hazard Class6.1
Storage condition -20°C -20℃ 2-8°C, protect from light
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 51 mg/kg
TOXIC EFFECTS :
   Details of

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 165 ug/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - chromodacryorrhea
   Gastrointestinal - hypermotility, diarrhea
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - true cholinesterase
REFERENCE :
   JAPMA8 Journal of the American Pharmaceutical Association, Scientific
   Edition.  (Washington, DC) V.29-49, 1940-60.  For publisher information, see
   JPMSAE.  Volume(issue)/page/year: 39,701,1950

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 420 ug/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 99,16,1950

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 130 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 16,164,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DO

其他信息

  • 毒性分级:剧毒
  • MSDS 信息:3-[[(Dimethylamino)carbonyl]oxy]-N,N,N-trimethylbenzenaminium methyl sulfate(51-60-5).msds
  • 类别:有毒物质
  • 可燃性危险特性:可燃, 燃烧时分解有毒氮氧化物, 硫氧化物气体
  • 图谱信息:甲基硫酸新斯的明(51-60-5)红外图谱(IR2) 甲基硫酸新斯的明(51-60-5)红外图谱(IR1) 甲基硫酸新斯的明(51-60-5)核磁图( 13 CNMR) 甲基硫酸新斯的明(51-60-5)核磁图( 1 HNMR)
  • 甲基硫酸新斯的明价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 N0447 甲硫酸新斯的明 Neostigmine Methyl Sulfate 5G 1250元 2011/04/16 N0447 甲硫酸新斯的明 Neostigmine Methyl Sulfate 25G 3300元
  • 甲基硫酸新斯的明价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 N0447 甲硫酸新斯的明 Neostigmine Methyl Sulfate 5G 740元 2014/06/02 N0447 甲硫酸新斯的明 Neostigmine Methyl Sulfate 25G 2290元
  • 急性毒性:皮下-大鼠 LD50: 0.334 毫克/公斤; 口服-小鼠 LD50: 7.5 毫克/公斤
  • MOL 文件:51-60-5.mol
  • color:white
  • 储运特性:库房低温, 通风, 干燥; 与食品原料分开存放
  • 灭火剂:水, 二氧化碳, 干粉, 砂土
  • Sigma Aldrich:51-60-5(sigmaaldrich)

系列性分类


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