CAS 53760-19-3 MFCD00010539-Cytochalasin H from Phomopsis sp. 细胞松驰素 H 来源于拟茎点霉属 TAO{mole}

Cytochalasin H from Phomopsis sp. 细胞松驰素 H 来源于拟茎点霉属

CAS 53760-19-3 MFCD00010539

化学结构图

SMILES: C[C@@]1(O)C[C@@H](C)CC=CC2[C@H](O)C(=C)[C@@H](C)C3[C@H](CC4C=CC=CC=4)NC(=O)[C@@]23[C@@H](C=C1)OC(C)=O |c:20,22,t:7,24,33|

化学属性

Mol. Formula	C30H39NO5
Mol. Weight	493.63
Melting Point	252-258 °C

别名和识别编码

Chemical Name	Cytochalasin H from Phomopsis sp.
MDL Number	MFCD00010539
Beilstein Registry Number	1632647
PubChem Substance ID	24892283
Synonym	Paspalin 细胞松驰素 H 来源于拟茎点霉属 Kodocytochalasin-1 Paspalin P I Cytochalasin-H 21-Acetoxy-7,18-dihydroxy-16,18-dimethyl-10-phenyl-(11)cytochalasa-6(12),13,19-triene-1-one
Wiswesser Line Notation	T56-11- 1A R AXVM GY JU PUTJ D1R& F1 GU1 HQ M1 OQ O1ROV1
CAS Number	53760-19-3
Chemical Name Translation	细胞松驰素 H 来源于拟茎点霉属

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安全信息

GHS Symbol

WGK Germany3

Precautionary statements

P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P284 Wear respiratory protection.? 佩戴呼吸保护装置。
P302+P350
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。

Hazard statements

H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
H330 Fatal if inhaled 吸入致命
H310 Fatal in contact with skin 皮肤接触致命
H300 Fatal if swallowed 吞食致命

RTECSHA5306000

Signal word Danger

Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

Hazard Codes T+

Safety Statements

S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；

Risk Statements

R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
R26/27/28 Very toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有剧毒

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JJEMAG Japanese Journal of Experimental Medicine.  (Kinokuniya Book-Stores
   of America Co., Ltd., West Bldg., Japan Cultural and Trade Center, 1581
   Webster St., San Francisco, CA 94115) V.7-    1928- Volume(issue)/page/year:
   48,105,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- ,  Berdy, J., Boca
   Raton, FL, CRC Press, 1980-  Volume(issue)/page/year: 2,439,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 2341 ug/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - changes in motor activity (specific assay)
   Behavioral - ataxia
REFERENCE :
   INDRBA Indian Drugs.  (Indian Drugs Manufacturers' Assoc., 102B, Poonam
   Chambers, Dr. A. B. Rd., Worli, Bombay 400 018, India)  V.1-    1963-
   Volume(issue)/page/year: 15,76,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : 12500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CJMIAZ Canadian Journal of Microbiology.  (National Research Council of
   Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.1-

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 500 ug/L
REFERENCE :
   IJEBA6 Indian Journal of Experimental Biology.  (Publications & Information
   Directorate, CSIR, Hillside Rd., New Delhi 110 012, India)  V.1-    1963-
   Volume(issue)/page/year: 16,430,1978