CAS 51-12-7 MFCD00010106-Nialamide 尼亚酰铵 TAO{mole}

Nialamide 尼亚酰铵

CAS 51-12-7 MFCD00010106

化学结构图

SMILES: O=C(CCNNC(=O)c1ccncc1)NCc1ccccc1

化学属性

Mol. Formula	C16H18N4O2
Mol. Weight	298
Melting Point	152-154 °C(lit.)

别名和识别编码

Chemical Name	Nialamide
CAS Number	51-12-7
MDL Number	MFCD00010106
Synonym	{uni_hamburg} 2-(2-(Benzylcarbamyl)ethyl)hydrazide isonicotinic acid 4-Pyridinecarboxylic acid, 2-[3-oxo-3-[(phenylmethyl)amino]propyl]hydrazide nialamide Delmoneurina N-Benzyl-beta-(isonicotinoylhydrazine)propionamide isonicotinic acid 2-[2-(benzylcarbamoyl)ethyl]hydrazide N-Benzyl-β-(isonicotinoylh Novazid Niamidal 1-[2-(Benzylcarbamoyl)ethyl]-2-isonicotinoylhydrazine N-异烟酰-N′-[β-(N-苄基甲酰氨基)乙基]肼 N-苄基-β-(异烟肼)丙酰胺吡啶-4-甲酰 2-[2-(苄基氨基甲酰)乙基]酰肼 Niaquitil Espril Isonicotinic acid, 2-[2-(benzylcarbamoyl)ethyl]hydrazide Nuredal N-(2-(Benzylcarbamyl)ethylamino)isonicotinamide N-Isonicotinoyl-N'(beta-N-benzylcarboxamidoethyl)hydrazine Isalizina Surgex 4-pyridinecarboxylic acid 2-[3-oxo-3-[(phenylmethyl) amino]propyl]hydrazide 2-[2-(Benzylcarbamoyl)ethyl]hydrazide isonicotinic acid Nyazin Niamid 尼亚酰铵 Niamide N1-Beta-Benzylcarbamoyl-ethyl-N2-isonicotinoyl-hydrazine BEIH N-benzyl-3-(2-isonicotinoylhydrazino)propionami Mygal 1-(2-(Benzylcarbamoyl)ethyl)-2-isonicotinoylhydrazine Delmoneurinaesprilisalizina N¹-β-Benzylcarbamoylethyl-N²isonicotinoylhydrazine N-Isonicotinoyl-N'-(β-N-benzylcarboxamidoethyl)hydrazine Isonicotinic acid, 2-[2-(benzylcarbamoylethyl]hydrazide N-Benzyl-β-(isonicotinylhydrazino)propionamide N(sup 1)-beta-Benzylcarbamoylethyl-N(sup 2)-isonicotinoylhydrazine Niazin N-Benzyl-beta-(isonicotinylhydrazino)propionamide P 1133 Psicodisten Nialamide {uni_hamb
PubChem Substance ID	4472
EC Number	200-079-3
Beilstein Registry Number	492941
Chemical Name Translation	尼亚酰铵
Wiswesser Line Notation	T6NJ DVMM2VM1R
LabNetwork Molecule ID	LN00239281
InChI	InChI=1S/C16H18N4O2/c21-15(18-12-13-4-2-1-3-5-13)8-11-19-20-16(22)14-6-9-17-10-7-14/h1-7,9-10,19H,8,11-12H2,(H,18,21)(H,20,22)

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分类

{SA} Bioactive Small Molecules, Biochemicals and Reagents, Building Blocks, C16+, Cell Biology, Cell Signaling and Neuroscience, Chemical Synthesis, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Heterocyclic Building Blocks, L to O, Monoamine Oxidase, Monoamine oxidase inhibitor, N, Neuroscience, Neurotransmission, Neurotransmitter Metabolism, Pyridines
{uni_hamburg} no charge; nitrogen heterocycle; carbocycle; aromatic; 6RingOnly; 6ring; amide; 1fragment
{SNA} Building Blocks, C16+, Chemical Synthesis, Heterocyclic Building Blocks, Pyridines

安全信息

GHS Symbol

WGK Germany3

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H335 May cause respiratory irritation 可能导致呼吸道刺激
H351 Suspected of causing cancer 怀疑致癌
H319 Causes serious eye irritation 严重刺激眼睛
H302+H312+H332
H332 Harmful if inhaled 吸入有害
H302 Harmful if swallowed 吞食有害
H312 Harmful in contact with skin 皮肤接触有害

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

RTECSNS1225000

Precautionary statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P305+P351+P338

Signal word Warning

Hazard Codes Xn

Safety Statements

S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36 Wear suitable protective clothing 穿戴适当的防护服；
S22 Do not breathe dust 不要吸入粉尘；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 25,158,1965

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       :

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1700 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory depression
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   TXAPA9 Toxicology an

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MPHEAE Medicina et Pharmacologia Experimentalis.  (Basel, Switzerland)
   V.12-17, 1965-67.  For publi

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 760 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory depression
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   1,524,1959

TYPE OF TEST            : Sister chromatid exchange
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 435 mg/kg
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Health.

TYPE OF TEST            : DNA damage
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 2450 umol/kg
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   41,1469,1981

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 10 ug/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 40,305,1976

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 10 ug/plate
REFERENCE :
   PLRCAT Pharmacological Research Communications.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.1-    1969-  Volume(issue)/page/year:
   12,423,1980

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 27 umol/plate
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Health.  (Hemisphere Pub.,
   1025 Vermont Ave., NW, Washington, DC 20005)  V.1-    1975/76-
   Volume(issue)/page/year: 9,287,1982

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 10 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 5,343,1968

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 24 mg/kg
SEX/DURATION            : female 1-6 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   JOENAK Journal of Endocrinology.  (Biochemical Soc. Book Depot, POB 32,
   Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1939-
   Volume(issue)/page/year: 27,147,1963

Nialamide 尼亚酰铵

CAS 51-12-7 MFCD00010106

化学结构图

化学属性

别名和识别编码

分类

相关文献及参考

安全信息

系列性分类

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